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    Resin composition and film suitable for agricultural covering material
    1.
    发明授权
    Resin composition and film suitable for agricultural covering material 失效
    树脂组合物和膜适用于农业覆盖材料

    公开(公告)号：US4828906A

    公开(公告)日：1989-05-09

    申请号：US093206

    申请日：1987-09-04

    申请人： Toshihiro Nishimura ,  Takashi Matsunaga

    发明人： Toshihiro Nishimura ,  Takashi Matsunaga

    IPC分类号： A01G13/00 ,  A01G13/02 ,  C08J5/18 ,  C08L23/00 ,  C08L23/08 ,  C08L23/14 ,  C08L23/18

    CPC分类号： A01G13/0275 ,  C08L23/0815 ,  C08L2205/02

    摘要： A film suitable for an agricultural covering material is formed from a resin composition comprising a blend comprising (A) an ethylene/.alpha.-olefin random copolymer having a low melt flow rate and (B) an ethylene/.alpha.-olefin copolymer having a high melt flow rate. The random copolymer (A) has a density (D.sub.A) of 0.935 to 0.950 g/cc and the random copolymer (B) has a density (D.sub.B) of 0.905 to 0.935 g/cc, and the density (D.sub.B) of the random copolymer (B) satisfies the requirement of D.sub.B .ltoreq.0.9D.sub.A +0.09 in which D.sub.A stands for the density of the copolymer (A).

    摘要翻译： 适用于农业覆盖材料的膜由包含（A）具有低熔体流动速率的乙烯/α-烯烃无规共聚物和（B）具有高熔体的乙烯/α-烯烃共聚物的共混物的树脂组合物形成 流量。 无规共聚物（A）的密度（DA）为0.935〜0.950g / cc，无规共聚物（B）的密度（DB）为0.905〜0.935g / cc，无规共聚物 （B）满足DB

    Bag for packaging heavy materials
    2.
    发明授权
    Bag for packaging heavy materials 失效
    袋包装重物料

    公开(公告)号：US5609930A

    公开(公告)日：1997-03-11

    申请号：US418376

    申请日：1995-04-07

    申请人： Takashi Matsunaga ,  Toshihiro Nishimura ,  Hiroshi Inoue

    发明人： Takashi Matsunaga ,  Toshihiro Nishimura ,  Hiroshi Inoue

    IPC分类号： B32B27/20 ,  B32B27/32 ,  B65D33/02

    CPC分类号： B32B27/32 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/24372 ,  Y10T428/24942 ,  Y10T428/2495 ,  Y10T428/24975 ,  Y10T428/258 ,  Y10T428/259 ,  Y10T428/31913

    摘要： A bag for packaging heavy materials, exhibiting excellent strength, content packaging performance, stacking performance on the pallets, and anti-collapsing performance. The bag is made of a multi-layer laminated film which comprises an outermost layer of a polyethylene film containing an inorganic filler in an amount of from 20 to 80% by weight and an innermost layer of a polyethylene film containing an inorganic filler in an amount of from 10 to 40% by weight, the outermost layer having on the surface thereof a coefficient of static friction of not smaller than 0.5 (ASTM D 1894), a coefficient of dynamic friction of not larger than 0.5 (ASTM D 1894) and a gloss of not larger than 50% (JIS Z 8741, at a measuring angle of 60.degree.), and the content of the inorganic filler in the innermost layer being from 1/2 to 1/6 of the content of the inorganic filler in the outermost layer.

    摘要翻译： 用于包装重材料的袋子，具有优异的强度，包装性能，托盘上的堆叠性能以及抗折叠性能。 该袋由多层层压膜制成，该多层层压膜包括含有20至80重量％的无机填料的聚乙烯膜的最外层，并且含有一定量的无机填料的聚乙烯膜的最内层 为10〜40重量％，最外层的表面的静摩擦系数为0.5以上（ASTM D 1894），动摩擦系数为0.5以下（ASTM D 1894）和 光泽度不大于50％（JIS Z 8741，测量角度为60度），最内层的无机填料的含量为+ E，fra 1/2 + EE至+ E， 6 + EE的最外层无机填料的含量。

    GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES
    5.
    发明申请
    GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES 有权
    葡萄糖醛酰氧基吡唑衍生物及其在药物中的应用

    公开(公告)号：US20090093419A1

    公开(公告)日：2009-04-09

    申请号：US12169882

    申请日：2008-07-09

    申请人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    发明人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    IPC分类号： A61K31/7056

    CPC分类号： A61K45/06 ,  A61K31/7056 ,  C07H17/02 ,  A61K2300/00

    摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

    摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T之一表示由通式表示的基团：（其中P表示氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。

    Resin compostion and stretched film obtained by using the same
    6.
    发明申请
    Resin compostion and stretched film obtained by using the same 有权
    通过使用它们获得的树脂组合物和拉伸膜

    公开(公告)号：US20070032601A1

    公开(公告)日：2007-02-08

    申请号：US10572385

    申请日：2004-09-17

    申请人： Tsutomu Tasaki ,  Toshihiro Nishimura ,  Hiroshi Inoue

    发明人： Tsutomu Tasaki ,  Toshihiro Nishimura ,  Hiroshi Inoue

    IPC分类号： C08L23/04

    CPC分类号： C08J5/18 ,  C08J2323/06 ,  C08J2323/08 ,  Y10S428/91 ,  Y10T428/31855 ,  Y10T428/31938

    摘要： The present invention relates to a polyethylene-based stretched film having excellent Elmendorf tear strength and uniform stretchability. The invention relates to a polyethylene-based stretched film which is obtained by stretching a polyethylene-based resin, wherein (A-i) Em and Et, which represent the values of Elmendorf tear strength in the MD and TD directions, respectively, as measured in accordance with ASTM D1922, satisfy the following formulas 1, 2 and 3: 20≦Em[N/m]≦3000  (Formula 1) 20≦Et[N/m]≦3000  (Formula 2) 0.1≦(Em/Et)≦3  (Formula 3); (a-ii) the tensile initial modulus TM in the MD direction satisfies the following formula 4: 300≦TM[MPa]≦10000  (Formula 4); and (a-iii) the thickness is in the range of 5 to 150 μm, and is excellent in the stretch uniformity.

    摘要翻译： 本发明涉及具有优异的埃尔门多夫撕裂强度和均匀拉伸性的聚乙烯基拉伸膜。 本发明涉及通过拉伸聚乙烯类树脂而获得的聚乙烯基拉伸膜，其中（Ai）Em和Et分别代表根据MD和TD方向的埃尔曼多夫撕裂强度值 与ASTM D1922相符合下列公式1,2和3：<？in-line-formula description =“In-line formula”end =“lead”？> 20 <= Em [N / m] <= 3000 1）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？> 20 <= Et [N / m] <= 3000（公式2）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“铅”？> 0.1 <=（Em / Et）<= 3（式3）; （a-ii）MD方向上的拉伸初始模量TM满足下列公式4：<？在线公式描述=“直线公式”end =“tail” =“在线公式”end =“lead”？> 300 <= TM [MPa] <= 10000（公式4）; <？in-line-formula description =“In-line Formulas”end =“tail”？>和（a-iii）厚度在5至150μm的范围内，并且拉伸均匀性优异。

    Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
    7.
    发明授权
    Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof 失效
    吡喃葡萄糖氧基苄基苯衍生物，含有它们的药物组合物及其制备中间体

    公开(公告)号：US07053060B2

    公开(公告)日：2006-05-30

    申请号：US10432905

    申请日：2001-11-20

    申请人： Hideki Fujikura ,  Toshihiro Nishimura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Norihiko Kikuchi ,  Kenji Katsuno ,  Masayuki Isaji

    发明人： Hideki Fujikura ,  Toshihiro Nishimura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Norihiko Kikuchi ,  Kenji Katsuno ,  Masayuki Isaji

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/00 ,  C07H17/00

    CPC分类号： C07H15/203

    摘要： The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom, a hydroxy group, a substituted or unsubstituted amino group, a carbamoyl group, a substituted or unsubstituted (lower alkyl) group, a substituted or unsubstituted (lower alkoxy) group etc.; R2 represents a hydrogen atom or a lower alkyl group; and R3 represents a substituted or unsubstituted (lower alkyl) group, a substituted or unsubstituted (lower alkoxy) group, a substituted or unsubstituted (lower alkylthio) group etc., or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complication or obesity, pharmaceutical compositions comprising the same and intermediates thereof.

    摘要翻译： 本发明涉及由以下通式表示的吡喃葡萄糖氧基苄基苯衍生物：其中R 1表示氢原子，羟基，取代或未取代的氨基，氨基甲酰基，取代或未取代的（低级烷基 ）基团，取代或未取代的（低级烷氧基）基团等; R 2表示氢原子或低级烷基; 和R 3表示取代或未取代的（低级烷基）基团，取代或未取代的（低级烷氧基）基团，取代或未取代的（低级烷硫基）等，或其药学上可接受的盐，其中 在人SGLT2中具有抑制活性，并且可用作预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂，包含其的药物组合物及其中间体。

    Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
    8.
    发明申请
    Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof 失效
    吡喃葡萄糖氧基苄基苯衍生物，含有它们的药物组合物及其制备中间体

    公开(公告)号：US20050059614A1

    公开(公告)日：2005-03-17

    申请号：US10978413

    申请日：2004-11-02

    申请人： Hideki Fujikura ,  Toshihiro Nishimura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Norihiko Kikuchi ,  Kenji Katsuno ,  Masayuki Isaji

    发明人： Hideki Fujikura ,  Toshihiro Nishimura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Norihiko Kikuchi ,  Kenji Katsuno ,  Masayuki Isaji

    IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07H15/203 ,  A61K31/70 ,  C07H5/04 ,  C07H5/06

    CPC分类号： C07H15/203

    摘要： The present invention relates to glucopyranosyl-oxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom, a hydroxy group, a substituted or unsubstituted amino group, a carbamoyl group, a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group etc.; R2 represents a hydrogen atom or a lower alkyl group; and R3 represents a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group, a substituted or unsubstituted(lower alkylthio) group etc., or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complication or obesity, pharmaceutical compositions comprising the same and intermediates thereof.

    摘要翻译： 本发明涉及由以下通式表示的吡喃葡萄糖基 - 氧苄基苯衍生物：其中R 1表示氢原子，羟基，取代或未取代的氨基，氨基甲酰基，取代或未取代的（低级烷基） 取代或未取代的（低级烷氧基）等。 R 2表示氢原子或低级烷基; 和R 3表示具有抑制活性的取代或未取代的（低级烷基）基团，取代或未取代的（低级烷氧基）基团，取代或未取代的（低级烷硫基）等，或其药学上可接受的盐 人SGLT2，并且可用作预防或治疗与高血糖相关的疾病（如糖尿病，糖尿病并发症或肥胖症）的药剂，包含其的药物组合物及其中间体。

    Polyethylene resin composition for heavy-duty packaging bag and polyethylene resin film produced from the same
    10.
    发明授权
    Polyethylene resin composition for heavy-duty packaging bag and polyethylene resin film produced from the same 失效
    用于重型包装袋和聚乙烯树脂膜的聚乙烯树脂组合物由其制成

    公开(公告)号：US5756193A

    公开(公告)日：1998-05-26

    申请号：US623147

    申请日：1996-03-28

    申请人： Akihiko Yamamoto ,  Naoshi Hamada ,  Toshihiro Nishimura ,  Kouji Kitahara

    发明人： Akihiko Yamamoto ,  Naoshi Hamada ,  Toshihiro Nishimura ,  Kouji Kitahara

    IPC分类号： B65D30/02 ,  B65D30/10 ,  C08F4/642 ,  C08J5/18 ,  C08L23/00 ,  C08L23/04 ,  C08L23/06 ,  C08L23/08

    CPC分类号： C08L23/0815 ,  C08L2205/02 ,  C08L2205/03 ,  C08L2205/035 ,  C08L23/06

    摘要： Disclosed is a polyethylene resin composition for heavy-duty packaging bag, which has a specific MFR, a specific density and a specific melt tension and which comprises (I) a linear low-density polyethylene resin prepared from ethylene and an .alpha.-olefin of 4 or more carbon atoms and having a specific MFR, a specific molecular weight distribution and a density of 0.900 to 0.918 g/cm.sup.3, (II) a linear medium or high-density polyethylene resin having a density of 0.935 to 0.970 g/cm.sup.3 and (III) a high-pressure low-density polyethylene resin having a density of 0.915 to 0.924 g/cm.sup.3, in a specific ratio of components. Also disclosed is a polyethylene resin film prepared from said composition. The composition is able to provide a film which is excellent in low-temperature properties such as low-temperature drop-bag strength and can be advantageously used for a heavy-duty packaging bag even in a cold district of below-freezing temperature. The polyethylene resin film exerts the above-mentioned effects.

    摘要翻译： 公开了一种用于重型包装袋的聚乙烯树脂组合物，其具有特定的MFR，比重密度和特定的熔体张力，并且包括（I）由乙烯和α-烯烃制备的线性低密度聚乙烯树脂 或更多的碳原子，并且具有特定的MFR，特定的分子量分布和0.900至0.918g / cm 3的密度，（II）密度为0.935至0.970g / cm3的线性介质或高密度聚乙烯树脂和（ III）以特定比例的组分密度为0.915至0.924g / cm 3的高压低密度聚乙烯树脂。 还公开了由所述组合物制备的聚乙烯树脂膜。 该组合物能够提供低温下降袋强度等低温性能优异的膜，即使在低于冰点的低温区域也能够有利地用于重型包装袋。 聚乙烯树脂膜发挥上述效果。