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31.发明授权Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders 有权针对RANK-L的氨基酸序列和包含其的多肽用于治疗骨骼疾病和病症公开(公告)号：US08623361B2
公开(公告)日：2014-01-07
申请号：US12599892
申请日：2008-05-23
IPC分类号： A61K39/395
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。
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32.发明授权Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries 有权构建包含肽，多肽或蛋白质不同家族的显示和/或表达成员的文库的方法和新型文库公开(公告)号：US08288322B2
公开(公告)日：2012-10-16
申请号：US10045674
申请日：2001-10-25
申请人： Robert C. Ladner , Edward H. Cohen , Horacio G. Nastri , Kristin L. Rookey , Rene Hoet , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Robert C. Ladner , Edward H. Cohen , Horacio G. Nastri , Kristin L. Rookey , Rene Hoet , Hendricus Renerus Jacobus Mattheus Hoogenboom
CPC分类号： C07K16/005 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C12N15/10 , C12N15/1037 , C12N15/1093 , C12N15/66 , C40B40/02 , C40B40/08
摘要： A library containing a collection of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and that collectively display at least a portion of the family, the displayed peptides, polypeptides or proteins being encoded by DNA sequences containing sequences encoding a heavy chain CDR region is described.
摘要翻译： 包含遗传包装的集合的图书馆，其显示肽，多肽或蛋白质的不同家族的成员，并且共同显示家族的至少一部分，显示的肽，多肽或蛋白质，其由含有编码 描述了重链CDR区。
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公开(公告)号：US08268756B2
公开(公告)日：2012-09-18
申请号：US11490545
申请日：2006-07-20
CPC分类号： C12N15/1086 , C07K16/10 , C07K16/20 , C07K16/40 , C07K2317/22 , C07K2317/569 , C07K2318/20 , C12N15/1082
摘要： Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and selecting for cells that have successfully integrated these nucleic acids. The selected cells are preferably subjected to a cloning step. Mixtures of binding proteins are produced without having to individually produce each of the components of the mixture. A library of cells wherein essentially each cell encodes at least two single polypeptide chain binding proteins having different target epitopes is also herewith provided, as well as methods for producing a composition comprising at least two separate single polypeptide chain binding proteins having different target epitopes.
摘要翻译： 描述了用于产生表达至少两个单独的多肽链结合蛋白的细胞文库的方法，其中结合蛋白具有不同的靶表位。 通过将编码多肽链的核酸序列整合到宿主细胞的基因组中并选择成功整合这些核酸的细胞来制备此类文库。 所选择的细胞优选进行克隆步骤。 产生结合蛋白的混合物，而不必单独产生混合物的每种组分。 还提供了其中基本上每个细胞编码至少两种具有不同靶表位的单个多肽链结合蛋白的细胞库，以及用于产生包含至少两种具有不同靶表位的单独多肽链结合蛋白的组合物的方法。
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34.发明申请AMINO ACID SEQUENCES THAT BIND TO SERUM PROTEINS IN A MANNER THAT IS ESSENTIALLY INDEPENDENT OF THE PH, COMPOUNDS COMPRISING THE SAME, AND USES THEREOF 审中-公开氨基酸序列与本质上独立于PH的化合物的血清蛋白质结合，包含其的化合物及其用途公开(公告)号：US20120148571A1
公开(公告)日：2012-06-14
申请号：US13184955
申请日：2011-07-18
CPC分类号： C07K14/001 , A61K38/00 , C12N15/1037
摘要： The present invention relates to amino acid sequences that bind to serum proteins such as serum albumin essentially independently in the pH range of 5 to 8; to compounds, proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.
摘要翻译： 本发明涉及在5至8的pH范围内基本独立地结合血清蛋白如血清白蛋白的氨基酸序列; 包括或基本上由这样的氨基酸序列组成的化合物，蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。
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35.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST RANK-L AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF BONE DISEASES AND DISORDERS 有权针对RANK-L指导的氨基酸序列和包含骨髓疾病和疾病治疗相关的多肽公开(公告)号：US20110002929A1
公开(公告)日：2011-01-06
申请号：US12599892
申请日：2008-05-23
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。
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36.发明申请AMINO ACID SEQUENCES THAT MODULATE THE INTERACTION BETWEEN CELLS OF THE IMMUNE SYSTEM 有权调节免疫系统细胞之间的相互作用的氨基酸序列公开(公告)号：US20100028341A1
公开(公告)日：2010-02-04
申请号：US12448260
申请日：2007-12-17
申请人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
发明人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
CPC分类号： C07K16/2818 , A61K47/643 , C07K14/76 , C07K16/2803 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences
摘要翻译： 本发明涉及阻断抗原呈递细胞（APC）上的靶标（APC）和（T细胞上的靶标）之间的相互作用的氨基酸序列。 更具体地，本发明涉及针对（如本文所定义）APC上的靶（本文中也称为“APC靶”）或T细胞上的靶（本文也称为“靶”）的氨基酸序列 “T细胞靶”）。 本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽
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37.发明申请PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE 审中-公开从抗体部分代码产生抗自身抗体并在噬菌体上显示公开(公告)号：US20090325815A1
公开(公告)日：2009-12-31
申请号：US12488343
申请日：2009-06-19
申请人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
发明人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
IPC分类号： C40B30/04
CPC分类号： C40B40/02 , B01J2219/00718 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/3007 , C07K16/3092 , C07K16/34 , C07K16/40 , C07K16/4208 , C07K16/4241 , C07K16/44 , C07K16/462 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , Y10S530/867
摘要： Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.
摘要翻译： 公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的特定哺乳动物种类的抗体或片段。 方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其作为抗体或抗体片段的特异性结合对的表面成员显示，并且每个含有rgdp的核酸序列衍生自物种 的哺乳动物。 每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。 通过与来自所述哺乳动物物种的自身抗原结合来选择抗自身抗体片段。 显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。 所用的核酸文库可能来源于未免疫哺乳动物的重排的V基因序列。 描述和显示合成或人造文库是有用的。
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38.发明授权Production of anti-self bodies from antibody segment repertories and displayed on phage 失效从抗体片段生产抗自身并显示在噬菌体上公开(公告)号：US06582915B1
公开(公告)日：2003-06-24
申请号：US09723756
申请日：2000-11-28
申请人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
发明人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
IPC分类号： C12Q168
CPC分类号： C40B40/02 , B01J2219/00718 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/3007 , C07K16/3092 , C07K16/34 , C07K16/40 , C07K16/4208 , C07K16/4241 , C07K16/44 , C07K16/462 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , Y10S530/867
摘要： Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from the said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from a rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.
摘要翻译： 公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的特定哺乳动物种类的抗体或片段。 方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其表面上显示作为抗体或抗体片段的特异性结合对的成员，以及每个含rgdp的核酸序列衍生自 哺乳动物的种类 每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。 通过与来自所述哺乳动物种的自身抗原结合来选择抗自身抗体片段。 显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。 所使用的核酸文库可以来源于未免疫的哺乳动物的重新排列的V基因序列。 描述和显示合成或人造文库是有用的。
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39.发明授权Production of anti-self antibodies from antibody segment repertoires and displayed on phage 失效从抗体片段制备抗自身抗体并在噬菌体上显示公开(公告)号：US06521404B1
公开(公告)日：2003-02-18
申请号：US09197224
申请日：1998-11-20
申请人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
发明人： Andrew David Griffiths , Hendricus Renerus Jacobus Mattheus Hoogenboom , James David Marks , John McCafferty , Gregory Paul Winter , Geoffrey Walter Grigg
IPC分类号： C12Q168
CPC分类号： C40B40/02 , B01J2219/00718 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/3007 , C07K16/3092 , C07K16/34 , C07K16/40 , C07K16/4208 , C07K16/4241 , C07K16/44 , C07K16/462 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , Y10S530/867
摘要： Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a specific binding pair which is an antibody or antibody fragment and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from the said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from a rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.
摘要翻译： 公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的特定哺乳动物种类的抗体或片段。 方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其表面显示特异性结合对的成员，其是抗体或抗体片段，并且每个含rgdp的核酸序列衍生自物种 的哺乳动物。 每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。 通过与来自所述哺乳动物种的自身抗原结合来选择抗自身抗体片段。 显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。 所使用的核酸文库可以来源于未免疫的哺乳动物的重新排列的V基因序列。 描述和显示合成或人造文库是有用的。
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