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    Method and system for improving memory interface data integrity in PLDs
    31.
    发明授权
    Method and system for improving memory interface data integrity in PLDs 有权
    改善PLD内存接口数据完整性的方法和系统

    公开(公告)号：US07102544B1

    公开(公告)日：2006-09-05

    申请号：US11142732

    申请日：2005-05-31

    Applicant: Hui Liu

    Inventor： Hui Liu

    IPC: H03M7/34

    CPC classification number: G06F11/1032

    Abstract: An integrated circuit (IC) for optimizing data presentation to an external memory interface bus is provided. The IC is in communication with the external memory via the external memory interface bus. The IC includes an encoder that may encode the data that are being sent to an external memory. The encoder encodes the data based on the logic value of the majority of bits in the data. The encoder is capable of setting a status bit to indicate that the data are encoded. Further connected in series with the encoder is a parity generator that sets the parity bit logic value based on whether the number of logic 1s in the data, along with the status bit, is even or odd. The IC also includes a parity checker to detect whether any error occurred in the data during transmission. The decoder within the IC decodes the data to the original data.

    Abstract translation: 提供了一种用于优化到外部存储器接口总线的数据呈现的集成电路（IC）。 IC通过外部存储器接口总线与外部存储器通信。 该IC包括编码器，其可以对正在发送到外部存储器的数据进行编码。 编码器根据数据中大多数位的逻辑值对数据进行编码。 编码器能够设置状态位以指示数据被编码。 进一步与编码器串联的是奇偶校验发生器，其基于数据中的逻辑1的数量以及状态位是偶数还是奇数来设置奇偶校验位逻辑值。 IC还包括一个奇偶校验器，用于检测在传输过程中数据是否发生错误。 IC内的解码器将数据解码为原始数据。

    Tocopherol associated protein and uses thereof
    35.
    发明授权
    Tocopherol associated protein and uses thereof 失效
    生育酚相关蛋白及其用途

    公开(公告)号：US07045324B2

    公开(公告)日：2006-05-16

    申请号：US10419629

    申请日：2003-04-21

    Applicant: Bob G. Sanders ,  Kimberly Kline ,  Weiping Yu ,  Hui Liu ,  Feras Hantash

    Inventor： Bob G. Sanders ,  Kimberly Kline ,  Weiping Yu ,  Hui Liu ,  Feras Hantash

    IPC: C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/04

    CPC classification number: C07K14/47 ,  A61K48/00 ,  C07K2319/00

    Abstract: The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.

    Abstract translation: 本发明提供了具有76个核苷酸碱基缺失的新的生育酚相关蛋白（TAP-38）DNA /蛋白，导致25个氨基酸缺失，随后90个新的核苷酸编码30个未被TAP- 46。 本发明提供了显示TAP-38增强基于生育酚的化合物的凋亡诱导性质的数据，并且TAP的阻断降低了基于生育酚的化合物的有效性。 因此，本发明要求肿瘤细胞中TAP-38的表达增强了基于生育酚的化合物的凋亡诱导性质。 本发明提供用于分别递送TAP-38和TAP-46 cDNA质粒的气溶胶脂质体/转染/感染方法，并与基于生育酚的凋亡诱导剂以及其它化学治疗剂一起用作治疗和预防细胞增殖的方法 疾病和病症。

    Removable pressure sensitive adhesives with plasticizer resistance properties
    36.
    发明授权
    Removable pressure sensitive adhesives with plasticizer resistance properties 失效
    具有耐增塑剂性能的可拆卸压敏粘合剂

    公开(公告)号：US06995207B2

    公开(公告)日：2006-02-07

    申请号：US10403487

    申请日：2003-03-31

    Applicant: Augustin T. Chen ,  Hui Liu ,  Leo Ternorutsky

    Inventor： Augustin T. Chen ,  Hui Liu ,  Leo Ternorutsky

    IPC: C08L33/00

    CPC classification number: C09J133/04 ,  C08L33/04 ,  C08L33/14 ,  C08L2205/02 ,  C08L2666/06 ,  C09J7/385 ,  Y10S526/931 ,  Y10T428/31855

    Abstract: A removable, plasticizer resistant pressure sensitive composition that is particularly useful for PSA applications on plasticizer containing vinyl films is provided. The pressure sensitive adhesive comprises: (a) at least one hydrophobic monomer; (b) about 0.2 to about 10 wt. % of at least one hydrophilic monomer; (c) about 1 to about 40 wt. % of one partially hydrophilic monomer (d) an effective amount of a crosslinker selected from diallyl maleate or a compound represented by the formula: wherein R is selected from hydrogen, methyl, or ethyl, and R′ is selected from vinyl, allyl, or methallyl; wherein the pressure sensitive adhesive does not contain a plasticizer.

    Abstract translation: 提供了一种可去除的，耐增塑剂的压敏组合物，其特别适用于含有增塑剂的乙烯基膜上的PSA应用。 压敏粘合剂包括：（a）至少一种疏水单体; （b）约0.2至约10wt。 ％的至少一种亲水性单体; （c）约1至约40wt。 ％的一种部分亲水性单体（d）有效量的选自马来酸二烯丙酯或由formu表示的化合物的交联剂

    Glycosidase inhibitors and methods of synthesizing same
    38.
    发明申请
    Glycosidase inhibitors and methods of synthesizing same 审中-公开
    糖苷酶抑制剂及其合成方法

    公开(公告)号：US20050065139A1

    公开(公告)日：2005-03-24

    申请号：US10877490

    申请日：2004-06-25

    Applicant: Brian Pinto ,  Blair Johnston ,  Monica Szczepina ,  Hui Liu ,  Kashinath Sadalapure ,  Ahmad Ghavami

    Inventor： Brian Pinto ,  Blair Johnston ,  Monica Szczepina ,  Hui Liu ,  Kashinath Sadalapure ,  Ahmad Ghavami

    IPC: A61K31/33 ,  A61K31/381 ,  A61K31/382 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/452 ,  A61P3/10 ,  C07D207/00 ,  C07D207/12 ,  C07D211/46 ,  C07D333/46 ,  C07D335/02 ,  C07D345/00 ,  C07H11/00

    CPC classification number: C07H11/00

    Abstract: A method for synthesizing Salacinol, its stereoisomers, and analogues, homologues and other derivatives thereof potentially useful as glycolsidase inhibitors. The compounds of the invention may have the general formula (I) or (II): The synthetic schemes comprise reacting a cyclic sulfate with a 5-membered ring sugar containing a heteroatom (X). The heteroatom preferably comprises sulfur, selenium, or nitrogen. The cyclic sulfate and ring sugar reagents may be readily prepared from carbohydrate precursors, such as D-glucose, L-glucose, D-xylose and L-xylose. The target compounds are prepared by opening of the cyclic sulfates by nucleophilic attack of the heteroatoms on the 5-membered ring sugars. The resulting heterocyclic compounds have a stable, inner salt structure comprising a heteroatom cation and a sulfate anion. The synthetic schemes yield various stereoisomers of the target compounds in moderate to good yields with limited side-reactions.

    Abstract translation: 合成Salacinol，其立体异构体和类似物的方法，其可能用作乙二醇酶抑制剂的同系物和其它衍生物。 本发明的化合物可以具有通式（I）或（II）：合成方案包括使环硫酸酯与含有杂原子（X）的5元环糖反应。 杂原子优选包含硫，硒或氮。 环状硫酸盐和环糖试剂可以容易地从碳水化合物前体如D-葡萄糖，L-葡萄糖，D-木糖和L-木糖制备。 通过在5元环糖上的杂原子的亲核攻击来打开环状硫酸盐来制备目标化合物。 所得的杂环化合物具有包含杂原子阳离子和硫酸根阴离子的稳定的内盐结构。 合成方案以有限的副反应以中等到良好的产率产生目标化合物的各种立体异构体。

    Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof
    39.
    发明授权
    Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof 失效
    中间体合成（±）喜树碱及相关化合物及其合成

    公开(公告)号：US06376676B1

    公开(公告)日：2002-04-23

    申请号：US09480824

    申请日：2000-01-10

    Applicant: Dennis P. Curran ,  Hui Liu

    Inventor： Dennis P. Curran ,  Hui Liu

    IPC: C07D21364

    CPC classification number: C07D471/14 ,  C07F7/083

    Abstract: The present invention provides a short, convergent total synthesis of novel intermediates in the synthesis of (±)-camptothecin and related compounds. The present synthesis scheme includes a novel 4+1 radical annulation followed by another cyclization to simultaneously assemble rings B and C of the camptothecin compound. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

    Abstract translation: 本发明提供了（±）喜树碱和相关化合物的合成中的新型中间体的短期收敛的全合成。 本合成方案包括一种新型的4 + 1自由基环化，随后另外环化以同时装配喜树碱化合物的环B和C。 本发明还提供了用于这种4 + 1自由基的新型化学中间体。

    Omerazole process and compositions thereof
    40.
    发明授权
    Omerazole process and compositions thereof 有权
    奥美拉唑法及其组合物

    公开(公告)号：US06191148B1

    公开(公告)日：2001-02-20

    申请号：US09461605

    申请日：1999-12-15

    Applicant: James W. McManus ,  Nick Anousis ,  Benjamin Newton Banks ,  Hui Liu ,  Lingwen Zhou

    Inventor： James W. McManus ,  Nick Anousis ,  Benjamin Newton Banks ,  Hui Liu ,  Lingwen Zhou

    IPC: A61K314439

    CPC classification number: C07D401/12

    Abstract: The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.

    Abstract translation: 本发明描述了一种用于制备，分离和纯化抗溃疡剂奥美拉唑的改进方法，其中硫化物前体pyrmetazole在氯代脂族烃或芳族烃溶剂中与恰好一摩尔当量的间氯过氧苯甲酸在地下反应， 如二氯甲烷或甲苯; 通过真空蒸馏从水层除去残留的有机溶剂; 粗产物通过与甲酸烷基酯或甲酸溶液反应结晶并接种获得; 通过在甲醇 - 含水NaOH水溶液中再次析出纯产物，通过地下加入乙酸水溶液至pH 9.0，接种，过滤，洗涤和干燥。 还描述了奥美拉唑和不含色谱可检测水平的残留的非酒精有机反应溶剂和降低的醇溶剂水平的奥美拉唑组合物。

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