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39 条记录 (耗时 0.051 秒)

    Analytical system with photonic crystal sensor
    34.
    发明授权
    Analytical system with photonic crystal sensor 有权
    光子晶体传感器分析系统

    公开(公告)号：US08497992B2

    公开(公告)日：2013-07-30

    申请号：US12616457

    申请日：2009-11-11

    申请人： Jingyong Ye ,  Jason E. Gestwicki ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Tommaso F. Bersano-Begey

    发明人： Jingyong Ye ,  Jason E. Gestwicki ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Tommaso F. Bersano-Begey

    IPC分类号： G01N21/55

    CPC分类号： G02B1/005 ,  B82Y20/00 ,  G01N21/553

    摘要： A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.

    摘要翻译： 用于确定试验物质与目标物质之间是否发生相互作用的系统。 该系统包括具有光子晶体结构的光子晶体传感器和邻近光子晶体结构设置的缺陷部件。 缺陷构件限定能够接收目标物质和试验物质的手术表面。 该系统还包括将光信号输入到光子晶体结构和缺陷部件的光源。 光信号被内部反射，并输出合成的输出信号。 输出信号涉及试验物质在操作表面与目标物质的相互作用。 此外，该系统包括识别与目标物质相互作用的试验物质的身份检测器。

    Acoustic monitoring method and system in laser-induced optical breakdown (LIOB)
    36.
    发明授权
    Acoustic monitoring method and system in laser-induced optical breakdown (LIOB) 有权
    激光诱导光学击穿中的声学监测方法和系统（LIOB）

    公开(公告)号：US07367948B2

    公开(公告)日：2008-05-06

    申请号：US10643659

    申请日：2003-08-19

    申请人： Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

    发明人： Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

    IPC分类号： A61B8/00 ,  A61B8/12 ,  A61B8/14 ,  A61B6/00 ,  A61H1/00

    CPC分类号： B82Y15/00 ,  A61B5/0095 ,  A61B8/481 ,  G01N21/1702 ,  G01N21/718 ,  G01N29/2418 ,  G01N2291/02433 ,  G01N2291/02475 ,  G01N2291/02491 ,  G01N2291/02827

    摘要： An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.

    摘要翻译： 激光诱导光学击穿（LIOB）中的声学监测方法和系统提供表征材料中的材料，材料中的微泡和/或微泡的微环境的信息。 在本发明的一个实施例中，飞秒激光脉冲恰好聚集在一定体积的水溶液的表面内，该溶液可包括树枝状聚合物纳米复合物（DNC）颗粒。 紧密聚焦的高频单元超声波换能器被定位成使得其焦点与该激光焦点轴向和横向重合。 当发生光学击穿时，形成微泡并发射冲击或压力波（即声发射）。 除了这种声学信号之外，微泡可以通过来自相同换能器的脉冲回波测量来主动探测。 在形成微泡后，接收的脉冲回波信号具有额外的脉冲，描述微泡位置并提供轴向微泡尺寸的量度。 连续记录的波场图说明了由于光学破坏引起的微泡的产生，生长和崩溃。 这些相同的图也可以用于量化LIOB阈值。

    Thyroid peroxidase epitopic regions
    39.
    发明授权
    Thyroid peroxidase epitopic regions 失效
    甲状腺过氧化物酶表位区

    公开(公告)号：US06528059B1

    公开(公告)日：2003-03-04

    申请号：US09251039

    申请日：1999-02-18

    申请人： James R. Baker, Jr. ,  Ronald J. Koenig

    发明人： James R. Baker, Jr. ,  Ronald J. Koenig

    IPC分类号： A61K3810

    CPC分类号： C12N9/0065 ,  A61K38/00 ,  A61K39/00 ,  G01N33/564 ,  G01N33/573 ,  G01N2800/24 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S530/854

    摘要： Specific epitopic regions of thyroid peroxidase (TPO), a thyroid specific membrane autoantigen, have been identified within amino acid residues 456 to 933, 457 to 633, 513 to 633, and 633 to 933 of the protein (SEQ ID NO:2), with at least one distinct binding region within TPO located from amino acid residues 592 to 613 (SEQ ID NO:7). The identification and production of these localized epitopes/epitopic regions provide specific therapeutic reagents for administration to autoimmune thyroid disease patients.

    摘要翻译： 已经在蛋白质（SEQ ID NO：2）的456至933,457至633,513至633和633至933的氨基酸残基内鉴定了甲状腺过氧化物酶（TPO），甲状腺特异性膜自身抗原的特异性表位区域， 与位于氨基酸残基592至613（SEQ ID NO：7）的TPO内的至少一个不同结合区。 鉴定和产生这些局部表位/表位区域为自身免疫性甲状腺疾病患者的给药提供了特异性的治疗试剂。