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公开(公告)号:US07955597B2
公开(公告)日:2011-06-07
申请号:US12507962
申请日:2009-07-23
申请人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
发明人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
IPC分类号: A61K39/395
CPC分类号: C07K16/248 , A01K67/0271 , A01K2267/0331 , A61K39/3955 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译: 本发明涉及至少一种衍生自鼠CLB-8抗体的新型嵌合,人源化或CDR移植的抗IL-6抗体,包括编码至少一种这样的抗IL-6抗体的分离的核酸,载体, 宿主细胞,转基因动物或植物,以及其制备和使用方法,包括治疗组合物,方法和装置。
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公开(公告)号:US07291721B2
公开(公告)日:2007-11-06
申请号:US10280716
申请日:2002-10-26
申请人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
发明人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
IPC分类号: C07H21/04
CPC分类号: C07K16/248 , A01K67/0271 , A01K2267/0331 , A61K39/3955 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译: 本发明涉及至少一种衍生自鼠CLB-8抗体的新型嵌合,人源化或CDR移植的抗IL-6抗体,包括编码至少一种这样的抗IL-6抗体的分离的核酸,载体, 宿主细胞,转基因动物或植物,以及其制备和使用方法,包括治疗组合物,方法和装置。
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33.
公开(公告)号:US20050163778A1
公开(公告)日:2005-07-28
申请号:US11018240
申请日:2004-12-21
申请人: David Peritt , Kim Campbell , Jill Giles-Komar , Gregory Harriman
发明人: David Peritt , Kim Campbell , Jill Giles-Komar , Gregory Harriman
IPC分类号: A61K31/366 , A61K31/37 , A61K35/12 , A61K35/14 , A61K35/15 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/395 , A61K41/00 , A61K45/00 , A61M1/36 , A61N1/30 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/02 , A61P37/06 , C07K16/24
CPC分类号: A61K35/15 , A61K38/1793 , A61K39/3955 , A61K41/0019 , A61K2039/505 , A61M1/3683 , C07K16/241 , A61K2300/00
摘要: Methods of treating an autoimmune disease, an atopic disease, transplantion rejection or GVHD or ameliorating one or more symptoms thereof involves the use of a combination therapy. The therapy involves administering to a subject an extracorporeal photopheresis and a TNF α antagonist.
摘要翻译: 治疗自身免疫性疾病,特应性疾病,移植排斥或GVHD或改善其一种或多种症状的方法涉及使用组合疗法。 该疗法包括向受试者施用体外光泳和TNFα拮抗剂。
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公开(公告)号:US09169461B2
公开(公告)日:2015-10-27
申请号:US11579319
申请日:2006-11-02
申请人: David Peritt , Kim Campbell , Amy Krutsick
发明人: David Peritt , Kim Campbell , Amy Krutsick
IPC分类号: C12N5/0783 , A61K31/366 , A61K31/59 , A61K35/17
CPC分类号: C12N5/0637 , A61K31/366 , A61K31/59 , A61K35/17 , C12N5/0636 , C12N2500/38 , C12N2501/15 , C12N2501/23 , C12N2501/231 , C12N2501/39 , C12N2502/11
摘要: Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).
摘要翻译: 身体中的许多细胞类型可以从组织中去除凋亡和细胞碎片; 然而,专业吞噬细胞或抗原呈递细胞(“APC”)具有很高的能力。 凋亡细胞(“AC”)的识别通过一系列进化保守的AC相关分子模式受体(“ACAMPR”)在APC上发生,其识别并结合相应的凋亡细胞相关分子模式(“ACAMP”)。 这些受体识别在凋亡细胞上发现的配体如磷脂酰丝氨酸和氧化的脂质。 Savill等人 (2002); 和格雷戈里(Gregory)等 (2004)。
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35.
公开(公告)号:US20050063944A1
公开(公告)日:2005-03-24
申请号:US10666490
申请日:2003-09-19
申请人: Jian Li , Lamine Mbow , Theresa Goletz , David Peritt
发明人: Jian Li , Lamine Mbow , Theresa Goletz , David Peritt
IPC分类号: A61K38/20 , C12N5/0784 , A61K38/19
CPC分类号: A61K38/20 , A61K35/15 , A61K38/19 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要: The invention relates to the induction of responses relating to the maturation of dendritic cells, using IL-18 and IL-18 muteins, and compounds, compositions, methods of making and using thereof, including therapeutic methods and products.
摘要翻译: 本发明涉及使用IL-18和IL-18突变蛋白对树突状细胞成熟的反应的诱导,以及其制备和使用方法,包括治疗方法和产品的化合物,组合物,方法。
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36.
公开(公告)号:US20060252674A1
公开(公告)日:2006-11-09
申请号:US11247111
申请日:2005-10-11
申请人: David Peritt , Gregory Harriman , Francine Foss
发明人: David Peritt , Gregory Harriman , Francine Foss
IPC分类号: A61K38/13 , A61K31/366 , A61K31/573 , A61K31/4745
CPC分类号: A61K31/37 , A61K35/14 , A61K35/17 , A61K41/00 , A61K49/0004 , A61L27/3804
摘要: The present invention relates to methods for treating a subject predisposed to an autoimmune disease with extracorporeal photopheresis or an effective amount of apoptotic cells before the clinical manifestation of a symptom associated with the autoimmune disease. The present invention alsorelates to methods for treating a subject predisposed to an atopic disease with extracorporeal photopheresis or an effective amount of apoptotic cells before the clinical manitfesation of a symptom associated with the atopic disease. The present invention further relates to methods for treating a transplant donor and/or a transplant recipient, or an implant recipient with extracorporeal photopheresis or an effective amount of apoptotic cells prior to the transplant or implantation procedure.
摘要翻译: 本发明涉及在与自身免疫性疾病相关的症状的临床表现之前用体外光泳法或有效量的凋亡细胞治疗倾向于自身免疫性疾病的受试者的方法。 本发明涉及用于在与特应性疾病相关症状的临床特征化之前用体外光泳法或有效量的凋亡细胞治疗倾向于特应性疾病的受试者的方法。 本发明还涉及用于在移植或植入手术之前治疗移植供体和/或移植受体或具有体外光泳术的植入物接收者或有效量的凋亡细胞的方法。
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公开(公告)号:US20080267934A1
公开(公告)日:2008-10-30
申请号:US11579319
申请日:2006-11-02
申请人: David Peritt , Kim Campbell , Amy Krutsick
发明人: David Peritt , Kim Campbell , Amy Krutsick
CPC分类号: C12N5/0637 , A61K31/366 , A61K31/59 , A61K35/17 , C12N5/0636 , C12N2500/38 , C12N2501/15 , C12N2501/23 , C12N2501/231 , C12N2501/39 , C12N2502/11
摘要: Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).
摘要翻译: 身体中的许多细胞类型可以从组织中去除凋亡和细胞碎片; 然而,专业吞噬细胞或抗原呈递细胞(“APC”)具有很高的能力。 凋亡细胞(“AC”)的识别通过一系列进化保守的AC相关分子模式受体(“ACAMPR”)在APC上发生,其识别并结合相应的凋亡细胞相关分子模式(“ACAMP”)。 这些受体识别在凋亡细胞上发现的配体如磷脂酰丝氨酸和氧化的脂质。 Savill等人 (2002); 和格雷戈里(Gregory)等 (2004)。
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公开(公告)号:US20070098686A1
公开(公告)日:2007-05-03
申请号:US11555978
申请日:2006-11-02
申请人: David Peritt , Kim Campbell , Amy Krutsick
发明人: David Peritt , Kim Campbell , Amy Krutsick
IPC分类号: A61K38/20 , A61K31/366 , A61K31/59
CPC分类号: C12N5/0637 , A61K31/366 , A61K31/59 , A61K35/17 , C12N5/0636 , C12N2500/38 , C12N2501/15 , C12N2501/23 , C12N2501/231 , C12N2501/39 , C12N2502/11
摘要: The present invention provides a method of generating T cells with regulatory activity by incubating leukocytes with autologous apoptotic peripheral blood mononuclear cells.
摘要翻译: 本发明提供了通过将白细胞与自体凋亡外周血单核细胞孵育来产生具有调节活性的T细胞的方法。
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