Use of apoptotic cells ex vivo to generate regulatory T cells
    34.
    发明授权
    Use of apoptotic cells ex vivo to generate regulatory T cells 有权
    使用凋亡细胞离体产生调节性T细胞

    公开(公告)号:US09169461B2

    公开(公告)日:2015-10-27

    申请号:US11579319

    申请日:2006-11-02

    摘要: Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).

    摘要翻译: 身体中的许多细胞类型可以从组织中去除凋亡和细胞碎片; 然而,专业吞噬细胞或抗原呈递细胞(“APC”)具有很高的能力。 凋亡细胞(“AC”)的识别通过一系列进化保守的AC相关分子模式受体(“ACAMPR”)在APC上发生,其识别并结合相应的凋亡细胞相关分子模式(“ACAMP”)。 这些受体识别在凋亡细胞上发现的配体如磷脂酰丝氨酸和氧化的脂质。 Savill等人 (2002); 和格雷戈里(Gregory)等 (2004)。

    Methods for pretreating a subject with extracorporeal photopheresis
    36.
    发明申请
    Methods for pretreating a subject with extracorporeal photopheresis 审中-公开
    用体外光离子体预处理受试者的方法

    公开(公告)号:US20060252674A1

    公开(公告)日:2006-11-09

    申请号:US11247111

    申请日:2005-10-11

    摘要: The present invention relates to methods for treating a subject predisposed to an autoimmune disease with extracorporeal photopheresis or an effective amount of apoptotic cells before the clinical manifestation of a symptom associated with the autoimmune disease. The present invention alsorelates to methods for treating a subject predisposed to an atopic disease with extracorporeal photopheresis or an effective amount of apoptotic cells before the clinical manitfesation of a symptom associated with the atopic disease. The present invention further relates to methods for treating a transplant donor and/or a transplant recipient, or an implant recipient with extracorporeal photopheresis or an effective amount of apoptotic cells prior to the transplant or implantation procedure.

    摘要翻译: 本发明涉及在与自身免疫性疾病相关的症状的临床表现之前用体外光泳法或有效量的凋亡细胞治疗倾向于自身免疫性疾病的受试者的方法。 本发明涉及用于在与特应性疾病相关症状的临床特征化之前用体外光泳法或有效量的凋亡细胞治疗倾向于特应性疾病的受试者的方法。 本发明还涉及用于在移植或植入手术之前治疗移植供体和/或移植受体或具有体外光泳术的植入物接收者或有效量的凋亡细胞的方法。

    Use of Apoptotic Cells Ex Vivo to Generate Regulatory T Cells
    37.
    发明申请
    Use of Apoptotic Cells Ex Vivo to Generate Regulatory T Cells 有权
    使用凋亡细胞体外产生调节性T细胞

    公开(公告)号:US20080267934A1

    公开(公告)日:2008-10-30

    申请号:US11579319

    申请日:2006-11-02

    摘要: Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).

    摘要翻译: 身体中的许多细胞类型可以从组织中去除凋亡和细胞碎片; 然而,专业吞噬细胞或抗原呈递细胞(“APC”)具有很高的能力。 凋亡细胞(“AC”)的识别通过一系列进化保守的AC相关分子模式受体(“ACAMPR”)在APC上发生,其识别并结合相应的凋亡细胞相关分子模式(“ACAMP”)。 这些受体识别在凋亡细胞上发现的配体如磷脂酰丝氨酸和氧化的脂质。 Savill等人 (2002); 和格雷戈里(Gregory)等 (2004)。