公开(公告)号：US20100062054A1

公开(公告)日：2010-03-11

申请号：US12619090

申请日：2009-11-16

申请人： Sergey Kazakov ,  Marian Kaholek ,  Kalle Levon

发明人： Sergey Kazakov ,  Marian Kaholek ,  Kalle Levon

IPC分类号： A61K9/127 ,  A61P43/00

CPC分类号： A61K9/5138 ,  A61K9/127 ,  A61K9/1273 ,  B01J13/02 ,  B82Y5/00 ,  C08J3/075 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989 ,  Y10T428/2991

摘要： Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.

摘要翻译： Lipobeads（脂质体包封的水凝胶）结合水凝胶和脂质体的特性，以创建对环境条件敏感的系统，并以快速时间尺度响应这些状况的变化。 脂质体可以通过在脂质体内聚合锚定或未锚定的水凝胶或通过将锚定或未锚定的水凝胶与脂质体混合来制备。 巨型脂蛋白可以通过在脂珠体中收缩未溶解的纳米凝胶并使所得脂质体聚集体缩短，锚定或未锚定脂肪细胞的长期老化或将锚定或未锚定的聚集的纳米凝胶与脂质体混合而产生。 制备聚（丙烯酰胺），聚（N-异丙基丙烯酰胺）和聚（N-异丙基丙烯酰胺 - 共-1-乙烯基咪唑）脂珠和表征。

公开(公告)号：US20070099823A1

公开(公告)日：2007-05-03

申请号：US11261400

申请日：2005-10-28

申请人： Olga Tarasenka ,  Kalle Levon

发明人： Olga Tarasenka ,  Kalle Levon

IPC分类号： A61K38/16 ,  A61K31/739

CPC分类号： A61K31/739

摘要： An inhibitor of sporeforming pathogens or agents. In one embodiment, the inhibitor has at least one glycoconjugate that is bondable to a sporeforming pathogen or agent. The glycoconjugate is a molecule containing a carbohydrate moiety that is glycosylated. The glycosylated carbohydrate moiety may comprise a glycoprotein or a glycolipid. In one embodiment, the glycosylated carbohydrate moiety comprises at least one disaccharide moiety or higher polysaccharide. In another embodiment, the glycosylated carbohydrate moiety comprises a plurality of copies of same monosaccharide units or different monosaccharide units.

摘要翻译： 形成病原体或药剂的抑制剂。 在一个实施方案中，抑制剂具有至少一个可与形成孢子的病原体或试剂结合的糖缀合物。 糖缀合物是含有被糖基化的碳水化合物部分的分子。 糖基化的碳水化合物部分可以包含糖蛋白或糖脂。 在一个实施方案中，糖基化的碳水化合物部分包含至少一种二糖部分或更高级的多糖。 在另一个实施方案中，糖基化碳水化合物部分包含相同单糖单元或不同单糖单元的多个拷贝。

公开(公告)号：US20050272105A1

公开(公告)日：2005-12-08

申请号：US10888530

申请日：2004-07-09

申请人： Kalle Levon ,  Bin Yu ,  Yanxiu Zhou

发明人： Kalle Levon ,  Bin Yu ,  Yanxiu Zhou

IPC分类号： A61F13/15 ,  C12M1/34 ,  C12Q1/00 ,  G01N20060101 ,  G01N33/543 ,  G01N33/552 ,  G01N33/554 ,  G01N33/569

CPC分类号： C12Q1/00 ,  C07K9/00 ,  C07K14/32 ,  C07K17/00 ,  C12Q1/003 ,  G01N33/53 ,  G01N33/54353 ,  G01N33/5438 ,  G01N33/54393 ,  G01N33/552

摘要： A real-time, portable peptide-containing potentiometric biosensor that can directly identify bacterial spores. Two peptides for specific recognition of B. subtilis and B. anthracis Sterne may be immobilized by a polysiloxane monolayer immobilization (PMI) technique. The sensors translate the biological recognition event into a potential change by detecting, for example, B. subtilis spores in a concentration range of 0.08-7.3×104 CFU/ml. The sensor exhibited highly selective recognition properties towards Bacillus subtilis spores over other kinds of spores. The selectivity coefficients of the sensors for other kinds of spores are in the range of 0-1.0×10−5. The biosensor system not only has the specificity to distinguish Bacillus subtilis spores in a mixture of B. subtilis and B. thuringiensis (thur.) Kurstaki spores, but also can discriminate between live and dead B. subtilis spores. Furthermore, the sensor can distinguish a Bacillus subtilis 1A700 from other B. subtilis strain. Assay time may be as low as about 5 minutes for a single test. Rapid identification of B. anthracis Sterne and B. anthracis ΔAmes was also provided.

摘要翻译： 一种可直接鉴定细菌孢子的实时便携式含肽电位生物传感器。 用于特异性识别枯草芽孢杆菌和炭疽芽孢杆菌的两种肽可以通过聚硅氧烷单层固定（PMI）技术来固定。 传感器通过检测例如浓度范围为0.08-7.3×10 4 CFU / ml的枯草芽孢杆菌孢子将生物识别事件转化为潜在的变化。 传感器表现出对枯草芽孢杆菌孢子与其他种类孢子的高选择性识别性能。 用于其他种类孢子的传感器的选择性系数在0-1.0×10 -5的范围内。 生物传感器系统不仅具有将枯草芽孢杆菌和苏云金芽孢杆菌（thur。）Kurstaki孢子的混合物中的枯草芽孢杆菌孢子区分开的特异性，而且可以区分活枯枯病芽孢杆菌孢子和活枯草芽孢杆菌孢子。 此外，传感器可以将枯草芽孢杆菌1A700与其他枯草芽孢杆菌菌株区分开来。 单次测试的测定时间可能低至约5分钟。 炭疽杆菌和炭疽杆菌的快速鉴定也提供了DeltaAmes。

公开(公告)号：US5391622A

公开(公告)日：1995-02-21

申请号：US237330

申请日：1994-05-03

申请人： Ko-Shan Ho ,  Kalle Levon

发明人： Ko-Shan Ho ,  Kalle Levon

IPC分类号： C08L101/00 ,  H01B1/12 ,  C08F28/06

CPC分类号： H01B1/127 ,  C08L101/00 ,  C08L2205/12

摘要： The present invention concerns electrically conducting polymer blends, processs for production thereof, and fibers and films essentially consisting of electrically conducting polymer blends. According to the invention, the polymer blends comprise matrix polymers and electrically conducting polymer components possessing liquid-crystal properties. In particular, the liquid-crystal polymer components comprise a main chain incorporating conjugated double bonds, the monomer units of the main chain being linked to side chains which, together with the main chain, render the polymer liquid-crystal properties at elevated temperatures. The blends are prepared by melt blending a matrix polymer and a liquid-crystal polymer and by treating the blend thus prepared with a dopant to make the liquid-crystal polymer conducting. The polymer blends can be processed into fibers or films using conventional processing methods of plastics such as die extrusion, injection molding, injection molding, ram molding or film blowing.

摘要翻译： 本发明涉及导电聚合物共混物，其制备方法，以及基本上由导电聚合物共混物组成的纤维和薄膜。 根据本发明，聚合物共混物包含基质聚合物和具有液晶性质的导电聚合物组分。 特别地，液晶聚合物组分包括含有共轭双键的主链，主链的单体单元连接到侧链，主链与主链一起在高温下呈现聚合物的液晶性质。 通过熔融共混基质聚合物和液晶聚合物并通过用掺杂剂处理由此制备的共混物以使液晶聚合物导电来制备共混物。 聚合物共混物可以使用塑料的常规加工方法加工成纤维或薄膜，例如模头挤出，注射成型，注射成型，冲压成型或薄膜吹塑。

公开(公告)号：US5346649A

公开(公告)日：1994-09-13

申请号：US988902

申请日：1992-12-04

申请人： Toivo Karna ,  Jukka Laakso ,  Kalle Levon ,  Esko Savolainen

发明人： Toivo Karna ,  Jukka Laakso ,  Kalle Levon ,  Esko Savolainen

IPC分类号： C08G73/02 ,  C08K5/42 ,  C08L25/04 ,  C08L79/00 ,  C08L79/02 ,  H01B1/12 ,  H01B1/00

CPC分类号： H01B1/128 ,  C08G73/0266 ,  C08K5/42 ,  C08L79/02 ,  C08L25/04

摘要： An electrically conducting plastic material is produced by blending a polyaniline or a derivative thereof with an organic sulfonic acid or a derivative thereof. A reaction product or blend of a polyaniline or a derivative thereof with an organic sulfonic acid or a derivative thereof can be brought to an easy-to-handle or directly melt-processable form through a heat-treatment process carried out at approx. +40.degree. to +250.degree. C. The obtained plastic material is advantageously further improved by blending the heat-treated reaction product or blend with a thermoplastic polymer and then melt-processing the mixed blend. The properties of the resulting compound material exhibit complete compatibility of the heat-treated reaction product or blend with the thermoplastic polymer.

摘要翻译： 通过将聚苯胺或其衍生物与有机磺酸或其衍生物共混来制造导电塑料材料。 聚苯胺或其衍生物与有机磺酸或其衍生物的反应产物或共混物可以通过在约3℃下进行的热处理过程使其易于处理或直接熔融加工形式。 + 40℃至+ 250℃。通过将热处理的反应产物或共混物与热塑性聚合物共混，然后熔融加工该混合共混物，所得塑料材料有利地进一步改进。 所得复合材料的性质表现出热处理反应产物或共混物与热塑性聚合物的完全相容性。