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    Indazole derivatives
    31.
    发明授权
    Indazole derivatives 失效
    吲唑衍生物

    公开(公告)号：US07906532B2

    公开(公告)日：2011-03-15

    申请号：US11995179

    申请日：2006-07-14

    申请人： Asako Ishibashi ,  Tomoki Kato ,  Kiyoshi Kawamura ,  Sachiko Mihara ,  Mikio Morita

    发明人： Asako Ishibashi ,  Tomoki Kato ,  Kiyoshi Kawamura ,  Sachiko Mihara ,  Mikio Morita

    IPC分类号： A61K31/454 ,  A61K31/416 ,  C07D211/56 ,  C07D231/56

    CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：R1，R2，R3，A和m各自如本文所述，含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4激动活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃肠疾病 恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经疾病，疼痛，心血管疾病，心力衰竭，心律失常，糖尿病和呼吸暂停综合征。

    1-Isopropyl-2-Oxo-1,2-dihydropyridine-3-carboxamide Derivatives having 5-HT4 Receptor Agonistic Activity
    32.
    发明申请
    1-Isopropyl-2-Oxo-1,2-dihydropyridine-3-carboxamide Derivatives having 5-HT4 Receptor Agonistic Activity 失效
    具有5-HT4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物

    公开(公告)号：US20100144789A1

    公开(公告)日：2010-06-10

    申请号：US12708012

    申请日：2010-02-18

    申请人： Tomoki Kato ,  Kiyoshi Kawamura ,  Chikara Uchida

    发明人： Tomoki Kato ,  Kiyoshi Kawamura ,  Chikara Uchida

    IPC分类号： A61K31/4545 ,  C07D401/12 ,  A61P1/00 ,  A61P1/08 ,  A61P1/04 ,  A61P25/00 ,  A61P25/28 ,  A61P9/00 ,  A61P9/06

    CPC分类号： C07D401/12 ,  C07D405/14

    摘要： This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

    摘要翻译： 本发明提供式（I）化合物：其中R 1表示具有1至4个碳原子的烷基或卤原子，R 2表示具有1至4个碳原子的烷基，R 3表示氢原子或羟基 基团，A表示氧原子或式-C（R4）（R5） - （其中R4表示氢原子或具有1至4个碳原子的烷基，R5表示羟基或式 具有1至4个碳原子的烷氧基）或其药学上可接受的盐。 这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

    1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
    33.
    发明授权
    1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity 失效
    具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物

    公开(公告)号：US07691881B2

    公开(公告)日：2010-04-06

    申请号：US10597480

    申请日：2005-01-18

    申请人： Tomoki Kato ,  Kiyoshi Kawamura ,  Chikara Uchida

    发明人： Tomoki Kato ,  Kiyoshi Kawamura ,  Chikara Uchida

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D405/14

    摘要： This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

    摘要翻译： 本发明提供式（I）化合物：其中R 1表示具有1至4个碳原子的烷基或卤原子，R 2表示具有1至4个碳原子的烷基，R 3表示氢原子或羟基 基团，A表示氧原子或式-C（R4）（R5） - （其中R4表示氢原子或具有1至4个碳原子的烷基，R5表示羟基或式 具有1至4个碳原子的烷氧基）或其药学上可接受的盐。 这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

    SIMULATION APPARATUS, SIMULATION METHOD AND COMPUTER-READABLE RECORDING MEDIUM ON OR IN WHICH SIMULATION PROGRAM IS RECORDED
    34.
    发明申请
    SIMULATION APPARATUS, SIMULATION METHOD AND COMPUTER-READABLE RECORDING MEDIUM ON OR IN WHICH SIMULATION PROGRAM IS RECORDED 有权
    模拟装置，模拟方法和可记录的计算机记录介质，或其中记录的模拟程序

    公开(公告)号：US20090313001A1

    公开(公告)日：2009-12-17

    申请号：US12393155

    申请日：2009-02-26

    申请人： Tomoki Kato ,  Noriyasu Nakayama ,  Hiroyuki Hieda

    发明人： Tomoki Kato ,  Noriyasu Nakayama ,  Hiroyuki Hieda

    IPC分类号： G06F17/50 ,  G06F9/45

    CPC分类号： G06F17/5009

    摘要： The present invention relates to a technique for executing performance evaluation simulation of a system to be implemented by software or hardware. A simulation apparatus includes a first acquisition section for executing existing tentative software to acquire a first execution log, a division section for dividing the first execution log into a plurality of basic processing units, a basic processing execution log production section for modifying some of the plural basic processing units to produce a basic processing execution log to be used for simulation, and a simulation execution section for inputting the basic processing execution log to a hardware model to execute the simulation to acquire information required for the performance evaluation.

    摘要翻译： 本发明涉及一种用于执行由软件或硬件实现的系统的性能评估仿真的技术。 模拟装置包括用于执行现有的暂时软件以获取第一执行日志的第一获取部分，用于将第一执行日志分成多个基本处理单元的分割部分，用于修改多个基本处理单元中的一些的基本处理执行日志生成部分 用于生成用于模拟的基本处理执行日志的基本处理单元，以及用于将基本处理执行日志输入到硬件模型以执行模拟以获取执行评估所需的信息的模拟执行部。

    Method of forming molded resin semiconductor device
    35.
    发明授权
    Method of forming molded resin semiconductor device 有权
    成型树脂半导体器件的形成方法

    公开(公告)号：US07534661B2

    公开(公告)日：2009-05-19

    申请号：US11702550

    申请日：2007-02-06

    申请人： Tomoki Kato

    发明人： Tomoki Kato

    IPC分类号： H01L21/00

    CPC分类号： H01L21/568 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A semiconductor chip and a wiring strip are placed on a flat side of a base sheet. The semiconductor chip has parallel first and second surfaces. Electrodes are connected to the first surface. The electrodes all terminate in the plane of the flat side of the base sheet and adhesively connected to the flat side of the base sheet. The wiring strip has one end portion connected to the second surface of the semiconductor chip and the opposite end portion terminating in the plane of the flat side of the base sheet and adhesively connected to the flat side of the base sheet. A mold resin fills gaps between the semiconductor chip, the wiring strip, and the base sheet to lock the semiconductor chip and the wiring strip. The base sheet is removed.

    摘要翻译： 将半导体芯片和布线条放置在基片的平坦侧上。 半导体芯片具有平行的第一和第二表面。 电极连接到第一表面。 电极全部终止于基片的平坦面的平面中，并且粘合地连接到基片的平坦侧。 布线条具有连接到半导体芯片的第二表面的一个端部和终止于基片的平坦侧的平面中的相对端部，并且粘合地连接到基片的平坦侧。 模具树脂填充半导体芯片，布线条和基片之间的间隙，以锁定半导体芯片和布线条。 去除基片。

    Molded resin semiconductor device having exposed semiconductor chip electrodes
    36.
    发明授权
    Molded resin semiconductor device having exposed semiconductor chip electrodes 有权
    具有暴露的半导体芯片电极的模制树脂半导体器件

    公开(公告)号：US07199455B2

    公开(公告)日：2007-04-03

    申请号：US10610648

    申请日：2003-07-02

    申请人： Tomoki Kato

    发明人： Tomoki Kato

    IPC分类号： H01L23/495

    CPC分类号： H01L21/568 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A semiconductor chip and a wiring strip are placed on a flat side of a base sheet. The semiconductor chip has parallel first and second surfaces. Electrodes are connected to the first surface. The electrodes all terminate in the plane of the flat side of the base sheet and adhesively connected to the flat side of the base sheet. The wiring strip has one end portion connected to the second surface of the semiconductor chip and the opposite end portion terminating in the plane of the flat side of the base sheet and adhesively connected to the flat side of the base sheet. A mold resin fills gaps between the semiconductor chip, the wiring strip, and the base sheet to lock the semiconductor chip and the wiring strip. The base sheet is removed.

    摘要翻译： 将半导体芯片和布线条放置在基片的平坦侧上。 半导体芯片具有平行的第一和第二表面。 电极连接到第一表面。 电极全部终止于基片的平坦面的平面中，并且粘合地连接到基片的平坦侧。 布线条具有连接到半导体芯片的第二表面的一个端部和终止于基片的平坦侧的平面中的相对端部，并且粘合地连接到基片的平坦侧。 模具树脂填充半导体芯片，布线条和基片之间的间隙，以锁定半导体芯片和布线条。 去除基片。

    1,4-dihydropyridine compounds as bradykinin antagonists
    38.
    发明授权
    1,4-dihydropyridine compounds as bradykinin antagonists 失效
    1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US06653313B2

    公开(公告)日：2003-11-25

    申请号：US09903157

    申请日：2001-07-11

    申请人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    发明人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    IPC分类号： A61K31496

    CPC分类号： A61K31/46 ,  A61K31/496 ,  C07D451/04 ,  Y02A50/411

    摘要： The present invention relates to compounds of the formula wherein each A is independently halo; Y is —(CH2)m—, —C(O)— or —S(O)—; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

    摘要翻译： 本发明涉及各种化合物，每个A独立地是卤素; Y是 - （CH 2）m - ， - C（O） - 或-S（O） - ; R 1和R 2独立地是C 1-4烷基; R 3是取代的氮杂环烷基等; R 4是在2-位上被取代基取代的C 1-7烷基，取代的C 1-7烷氧基，胺等取代的苯基; R 5是氢或C 1-4烷基; m为0,1或2; 本发明还涉及含有这些化合物的药物组合物以及这些化合物在治疗和预防炎症，哮喘，变应性鼻炎，疼痛和其它疾病中的用途 。