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公开(公告)号：US08190251B2
公开(公告)日：2012-05-29
申请号：US11565268
申请日：2006-11-30
申请人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
发明人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
IPC分类号： A61B5/04
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A method, apparatus, and system for treating patients suffering from movement disorders having the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.
摘要翻译： 用于治疗患有运动障碍的患者的方法，装置和系统，其具有确定指示疾病状态的一种或多种生物标志物的能力。 在一些实施方案中，生物标志物可以用作闭环反馈信号以控制治疗的递送（例如电刺激或药物治疗），并且其也可以用作治疗有效性的指示。 一个实施例使用放置在脑中的电极来测量EEG或局部场电位（LFP）信号，从该信号可以确定一个或多个生物标志物。
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公开(公告)号：US08121694B2
公开(公告)日：2012-02-21
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US20110190851A1
公开(公告)日：2011-08-04
申请号：US12699668
申请日：2010-02-03
CPC分类号： A61B5/053 , A61N1/00 , A61N1/3614 , A61N1/36521 , A61N1/3702
摘要： Implantable medical devices switch from a constant current mode of operation to a constant voltage mode of operation. The switching may be based on the device determining that tissue impedance stability has occurred. The determination may be a measurement of output voltage stability of the constant current source or based on other factors such as an amount of time that has elapsed. The switching may be as the result of an externally generated request such as by a clinician via an external device. The implantable medical device may begin constant voltage mode by utilizing stimulation parameters based on those initially programmed for constant current mode and based upon a measurement of voltage amplitude being output by the constant current source prior to the switch.
摘要翻译： 可植入医疗设备从恒定电流工作模式切换到恒压工作模式。 切换可以基于确定发生了组织阻抗稳定性的设备。 该确定可以是恒定电流源的输出电压稳定性的测量，或者基于其他因素，例如已经经过的时间量。 切换可能是外部产生的请求的结果，例如由临床医生经由外部设备。 可植入医疗装置可以通过利用基于最初为恒定电流模式编程的刺激参数并且基于在切换之前由恒定电流源输出的电压幅度的测量来开始恒定电压模式。
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公开(公告)号：US07761146B2
公开(公告)日：2010-07-20
申请号：US11609432
申请日：2006-12-12
IPC分类号： A61B5/04
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译： 用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。 本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。 本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。 其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。 本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。 本发明的另一个实施方案包括在递送治疗后检测发作活动。
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公开(公告)号：US07149572B2
公开(公告)日：2006-12-12
申请号：US10687570
申请日：2003-10-15
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/048 , A61B5/4094 , A61M5/14276 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N2/006 , G06F19/00
摘要： Method and apparatus for phase shifting neurological signals received from monitoring elements of a medical device. The medical device comprises a plurality of monitoring elements each receiving a neurological signal. The device processes the neurological signals and identifies a time shift of the neurological signals relative to each other. The neurological signals are then time shifted according to the time shift upon which the signals are utilized to provide closed-loop feedback control of a treatment therapy.
摘要翻译： 用于从医疗装置的监视元件接收的相移神经信号的方法和装置。 医疗装置包括多个监测元件，每个监测元件接收神经信号。 该装置处理神经信号并识别神经信号相对于彼此的时间偏移。 神经信号然后根据信号被用于提供治疗治疗的闭环反馈控制的时间偏移而被时移。
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公开(公告)号：US5067096A
公开(公告)日：1991-11-19
申请号：US582574
申请日：1990-09-14
申请人： David P. Olson , Jonathan C. Werder
发明人： David P. Olson , Jonathan C. Werder
摘要： A target engagement system uses target motion analysis to determine a target engagement decision for ground targets, such as vehicles. The input to the engagement system is the target azimuth as a function of time. A detect algorithm issues and records a detect azimuth when confirmation is made that a valid target is being tracked and legitimate azimuth information is being provided. The engagement algorithm then begins and records the time intervals it takes for the target to cross two sectors, each covering 20.degree. and separate by 10.degree.. Thus, first time interval is measured from detect azimuth to 20.degree. after detect azimuth, and the second time interval is measured from 30.degree. after detect azimuth to 50.degree. after detect azimuth. When the first and second time intervals have been recorded, the ratio of the first time interval to the second time interval is calculated. If this ratio is greater than 2.0, then the target is estimated to be within range and is subsequently attacked. Otherwise, the target is greater than the range and no action is taken.
摘要翻译： 目标参与系统使用目标运动分析来确定地面目标（如车辆）的目标参与决策。 接合系统的输入是作为时间的函数的目标方位角。 当确认正在跟踪有效目标并且正在提供合法的方位信息时，检测算法发出并记录检测方位角。 然后，参与算法开始并记录目标跨越两个扇区所需的时间间隔，每个扇区覆盖20°并分隔10°。 因此，在检测方位角后，从检测方位角到20°测量第一时间间隔，第二个时间间隔从检测方位角后的30°测量到方位角后测量到50°。 当记录了第一和第二时间间隔时，计算第一时间间隔与第二时间间隔的比率。 如果该比例大于2.0，则目标估计在范围内并随后被攻击。 否则，目标大于范围，不采取任何行动。
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公开(公告)号：US07976465B2
公开(公告)日：2011-07-12
申请号：US11550294
申请日：2006-10-17
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/048 , A61B5/4094 , A61M5/14276 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N2/006 , G06F19/00
摘要： Method and apparatus for phase shifting neurological signals received from monitoring elements of a medical device. The medical device comprises a plurality of monitoring elements each receiving a neurological signal. The device processes the neurological signals and identifies a time shift of the neurological signal relative to each other. The neurological signals are then time shifted according to the time shift upon which the signals are utilized to provide closed-loop feedback control of a treatment therapy.
摘要翻译： 用于从医疗装置的监视元件接收的相移神经信号的方法和装置。 医疗装置包括多个监测元件，每个监测元件接收神经信号。 该装置处理神经信号并识别神经信号相对于彼此的时间偏移。 神经信号然后根据信号被用于提供治疗治疗的闭环反馈控制的时间偏移而被时移。
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