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公开(公告)号：US10508260B2
公开(公告)日：2019-12-17
申请号：US16299048
申请日：2019-03-11
申请人： I Peace, Inc. , Koji Tanabe
发明人： Koji Tanabe , Brendan Kelly , Kenta Suto , Hidenori Shimoda , Ryoji Hiraide
IPC分类号： C12M1/00 , C12M1/36 , C12M1/42 , C12M1/33 , C12N5/074 , C12M1/12 , C12M3/00 , C12N5/078 , C12M1/34 , C12M1/02
摘要： A cell mass dissociator for a pluripotent stem cell production system.
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公开(公告)号：US09506039B2
公开(公告)日：2016-11-29
申请号：US13991341
申请日：2011-12-02
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/115 , C12N2501/415 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.
摘要翻译： 本发明提供了一种通过在体细胞核重编程步骤中增加一种或多种蛋白质的活化形式的水平来提高诱导多能干细胞的建立效率的方法，该蛋白质选自Ras家族成员，PI3激酶 ，RalGEF，Raf，AKT家族成员，Rheb，TCL1和S6K。 本发明还提供了通过使体细胞与核重编程物质和一种或多种这样的蛋白质和编码这种蛋白质的核酸接触来产生诱导性多能干细胞的方法。 本发明还提供了具有编码这种蛋白质的外源核酸的诱导多能干细胞，以及用于上述方法的试剂。
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公开(公告)号：US20130267030A1
公开(公告)日：2013-10-10
申请号：US13991341
申请日：2011-12-02
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/115 , C12N2501/415 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.
摘要翻译： 本发明提供了一种通过在体细胞核重编程步骤中增加一种或多种蛋白质的活化形式的水平来提高诱导多能干细胞的建立效率的方法，该蛋白质选自Ras家族成员，PI3激酶 ，RalGEF，Raf，AKT家族成员，Rheb，TCL1和S6K。 本发明还提供了通过使体细胞与核重编程物质和一种或多种这样的蛋白质和编码这种蛋白质的核酸接触来产生诱导性多能干细胞的方法。 本发明还提供了具有编码这种蛋白质的外源核酸的诱导多能干细胞，以及用于上述方法的试剂。
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34.发明授权公开(公告)号：US08199122B2
公开(公告)日：2012-06-12
申请号：US12428047
申请日：2009-04-22
申请人： Yasutaka Yamamoto , Koji Tanabe
发明人： Yasutaka Yamamoto , Koji Tanabe
IPC分类号： G09G5/00
CPC分类号： G06F3/0414 , G06F3/045 , Y10T428/25
摘要： A pressure sensitive conductive sheet is provided by having a plurality of ferromagnetic conductive particles dispersed in a transparent elastic member joined together and linearly aligned with the thickness direction thereby forming a linear aggregate and then having the linear aggregate segmented into a plurality conductive elements, held linearly aligned with the thickness direction, with predetermined gaps formed therebetween. Further, a touch panel having good transparency and allowing stabilized operation is provided by interposing the pressure sensitive conductive sheet between an upper conductive layer on the lower face of an upper substrate and a lower conductive layer on the upper face of a lower substrate.
摘要翻译： 通过具有分散在连接在一起并与厚度方向线性对准的透明弹性部件中的多个铁磁性导电粒子形成压敏导电片，从而形成直线聚集体，然后将线状聚集体分段成多个导电元件，线性地保持 与厚度方向对准，其间形成有预定的间隙。 此外，通过在上基板的下表面上的上导电层和下基板的上表面的下导电层之间插入压敏导电片，提供了具有良好的透明度并且允许稳定的操作的触摸面板。
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35.发明授权Movable contact assembly including light inlet having plural grooves, and switch using the same 失效可移动接触组件，包括具有多个凹槽的光入口和使用其的开关公开(公告)号：US08143541B2
公开(公告)日：2012-03-27
申请号：US12246417
申请日：2008-10-06
申请人： Koji Tanabe , Yousuke Chikahisa , Tsutomu Aisaka
发明人： Koji Tanabe , Yousuke Chikahisa , Tsutomu Aisaka
IPC分类号： H01H9/00
CPC分类号： H01H13/83 , H01H2205/016 , H01H2209/002 , H01H2209/082 , H01H2219/044 , H01H2219/056 , H01H2219/06 , H01H2219/062 , H01H2221/07
摘要： A movable contact assembly includes a light guiding sheet which is light transmittable, and a movable contact provided on the light guiding sheet. The light guiding sheet has a portion having the movable contact provided thereon and a portion having plural grooves provided therein. The grooves constitute a light inlet for introducing light into the light guiding sheet. This movable contact assembly can illuminate a switch preferably with a simple structure, providing the switch with an easily operation.
摘要翻译： 可移动接触组件包括可透光的导光片和设置在导光片上的可动触头。 导光片具有设置在其上的可动触头的部分和设置在其中的多个凹槽的部分。 凹槽构成用于将光引入导光片的光入口。 该可动触头组件可以以简单的结构照亮开关，为开关提供容易的操作。
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公开(公告)号：US20110250692A1
公开(公告)日：2011-10-13
申请号：US13059188
申请日：2009-10-30
申请人： Shinya Yamanaka , Koji Tanabe
发明人： Shinya Yamanaka , Koji Tanabe
CPC分类号： C12N5/0696 , C12N2501/603 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2510/00
摘要： The present invention relates to a method for producing mammalian induced pluripotent stem cells, comprising introducing mammal-derived reprogramming factors comprising Oct3/4 and Nanog, or nucleic acids encoding Oct3/4 and Nanog, into mammal-derived somatic cells and thereby inducing induced pluripotent stem cells from the somatic cells, wherein the reprogramming factors comprise neither Sox2 nor nucleic acid encoding Sox2.
摘要翻译： 本发明涉及一种用于产生哺乳动物诱导的多能干细胞的方法，其包括将包含Oct3 / 4和Nanog的哺乳动物衍生的重编程因子或编码Oct3 / 4和Nanog的核酸引入哺乳动物衍生的体细胞，从而诱导诱导的多能干细胞 来自体细胞的干细胞，其中重编程因子既不包括Sox2也不包含编码Sox2的核酸。
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公开(公告)号：US07710406B2
公开(公告)日：2010-05-04
申请号：US11649207
申请日：2007-01-04
申请人： Shoji Fujii , Koji Tanabe
发明人： Shoji Fujii , Koji Tanabe
IPC分类号： G09G5/00
CPC分类号： G06F3/0416
摘要： A touch panel includes a first substrate, a second substrate, a wiring substrate provided with a plurality of wiring patterns formed thereon, and an anisotropic conductive adhesive layer. The first substrate has a first conductive layer and first electrodes extending from two opposite sides of the first conductive layer. The second substrate has a second conductive layer confronting the first surface with a space, and second electrodes extending from two opposite sides of the second conductive layer. The anisotropic conductive adhesive layer connects a terminal portion of the wiring patterns to at least one of the first electrodes and the second electrodes. The wiring substrate has a slit or an aperture between the wiring patterns at one end thereof. The touch panel of this structure is easy to produce, and provides reliable operation and electrical connection and separation.
摘要翻译： 触摸面板包括第一基板，第二基板，设置有形成在其上的多个布线图案的布线基板和各向异性导电粘合剂层。 第一基板具有第一导电层和从第一导电层的两个相对侧延伸的第一电极。 第二基板具有面对第一表面的空间的第二导电层，以及从第二导电层的两个相对侧延伸的第二电极。 各向异性导电粘合剂层将布线图案的端子部分连接到第一电极和第二电极中的至少一个。 布线基板的一端具有在布线图案之间的狭缝或孔。 该结构的触摸屏易于生产，并提供可靠的操作和电气连接和分离。
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公开(公告)号：US07692728B2
公开(公告)日：2010-04-06
申请号：US11969593
申请日：2008-01-04
申请人： Kenichi Matsumoto , Koji Tanabe
发明人： Kenichi Matsumoto , Koji Tanabe
IPC分类号： G01F1/1333
CPC分类号： G02F1/13338 , G02F1/133528 , G02F2201/50
摘要： Disclosed here is a touch panel with improved visibility. The polarizing plate of the touch panel has a laminated structure in which the polarizing layer is sandwiched between the upper protective layer and the lower protective layer. Of the three layers, the lower protective layer is formed as a phase-difference layer with ¼ wavelength made of a cycloolefin-based polymer. The structure protects the polarizing plate from distortion and deterioration, offering good visibility. At the same time, the structure above contributes to a reduced parts count and accordingly a cost-reduced touch panel.
摘要翻译： 这里公开了具有改进的可视性的触摸面板。 触摸面板的偏振片具有偏振层夹在上保护层和下保护层之间的层叠结构。 在三层中，下保护层形成为由环烯烃类聚合物制成的1/4波长的相差层。 该结构保护了偏振片的变形和变质，提供了良好的可视性。 同时，上述结构有助于减少零件数量，从而降低了成本降低的触摸面板。
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公开(公告)号：US20090323357A1
公开(公告)日：2009-12-31
申请号：US12433141
申请日：2009-04-30
申请人： Koji Tanabe
发明人： Koji Tanabe
IPC分类号： F21V7/00
CPC分类号： H01H13/88 , G02B6/004 , G02F2001/1672 , G06F1/1613 , G06F1/1662 , G06F3/0202 , H01H2219/018 , H01H2219/044 , H01H2219/056 , H01H2219/062 , H04M1/22
摘要： A light guide sheet and a movable contact element using the sheet are inexpensive and provide adequate illumination. In the light guide sheet, light-transmissive upper conductive layers, reflective layers, and lower conductive layers are laminated in this order in predetermined positions on the bottom surface of a light-transmissive, film-like cover sheet. The reflective layers have reverse particles dispersed therein, whose top and bottom surfaces are reversed between light color and dark color.
摘要翻译： 使用该片材的导光片和可动触点元件便宜并提供足够的照明。 在导光片中，透光性上导电层，反射层和下导电层依次层叠在透光性膜状覆盖片的底面上的规定位置。 反射层具有分散在其中的反向颗粒，其顶表面和底表面在浅色和深色之间相反。
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40.发明申请公开(公告)号：US20090226689A1
公开(公告)日：2009-09-10
申请号：US12400192
申请日：2009-03-09
CPC分类号： H01H13/785 , H01H2201/036 , Y10T428/24942 , Y10T428/25
摘要： A pressure sensitive conductive sheet includes a film-like base material, and a low resistive layer and a high resistive layer, which are formed in this order on the bottom surface of the base material. The high resistive layer has soft particles and hard particles different in average particle size dispersed therein. There are fixed contacts formed under the bottom surface of the high resistive layer. The pressure sensitive conductive sheet and a panel switch using the sheet have small variations in the resistance change after repeated pressing, thereby providing reliable operation.
摘要翻译： 压敏导电片包括在基材的底表面上依次形成的膜状基材和低电阻层和高电阻层。 高电阻层具有分散在其中的软颗粒和平均粒度不同的硬颗粒。 在高电阻层的底表面下方形成有固定的触点。 压敏导电片和使用该片的面板开关在重复按压之后的电阻变化有小的变化，从而提供可靠的操作。
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