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51 条记录 (耗时 0.123 秒)

    Porcine mpl ligand
    31.
    发明授权
    Porcine mpl ligand 失效
    猪mpl配体

    公开(公告)号：US06660256B1

    公开(公告)日：2003-12-09

    申请号：US08348657

    申请日：1994-12-02

    申请人： Dan L. Eaton ,  Frederic J. de Sauvage

    发明人： Dan L. Eaton ,  Frederic J. de Sauvage

    IPC分类号： A61K3819

    CPC分类号： C07K14/524 ,  A61K38/00

    摘要： Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are used for treatment of thrombocytopenia.

    摘要翻译： 公开了分离的mpl配体，编码mpl配体的分离的DNA和制备mpl配体的重组方法。 显示这些mpl配体影响血液细胞，特别是巨核细胞祖细胞的复制，分化或成熟。 因此，这些化合物用于治疗血小板减少症。

    Method of diagnosing the presence of a tumor in a mammal by assessing CDO expression levels
    33.
    发明授权
    Method of diagnosing the presence of a tumor in a mammal by assessing CDO expression levels 有权
    通过评估CDO表达水平来诊断哺乳动物肿瘤存在的方法

    公开(公告)号：US08435754B2

    公开(公告)日：2013-05-07

    申请号：US13286695

    申请日：2011-11-01

    申请人： Frederic J. de Sauvage ,  Hua Tian

    发明人： Frederic J. de Sauvage ,  Hua Tian

    IPC分类号： G01N33/574 ,  C07K16/28

    CPC分类号： C12N5/069 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/392 ,  C12N2501/41 ,  G01N33/57484

    摘要： The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

    摘要翻译： 本发明提供了使用BOC / CDO刺猬蛋白拮抗剂抑制刺猬蛋白信号传导的方法，以及治疗和诊断与刺猬蛋白信号传导或过度表达刺猬的疾病，包括癌症，细胞增殖性疾病和血管发生，神经障碍，以及 作为受刺猬信号传导影响的其他条件，如毛发生长，神经干细胞分化，软骨形成和成骨，肺表面活性物质生成，肺细胞中层状体的形成。

    Method of Diagnosing the presence of a tumor in a mammal by assessing CDO expression level
    34.
    发明申请
    Method of Diagnosing the presence of a tumor in a mammal by assessing CDO expression level 有权
    通过评估CDO表达水平来诊断哺乳动物肿瘤存在的方法

    公开(公告)号：US20120128585A1

    公开(公告)日：2012-05-24

    申请号：US13286695

    申请日：2011-11-01

    申请人： Frederic J. de Sauvage ,  Hua Tian

    发明人： Frederic J. de Sauvage ,  Hua Tian

    IPC分类号： A61K49/00 ,  A61P35/00 ,  C12Q1/68 ,  A61K51/04 ,  A61K39/395 ,  G01N33/53

    CPC分类号： C12N5/069 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/392 ,  C12N2501/41 ,  G01N33/57484

    摘要： The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

    摘要翻译： 本发明提供了使用BOC / CDO刺猬蛋白拮抗剂抑制刺猬蛋白信号传导的方法，以及治疗和诊断与刺猬蛋白信号传导或过度表达刺猬的疾病，包括癌症，细胞增殖性疾病和血管发生，神经障碍，以及 作为受刺猬信号传导影响的其他条件，如毛发生长，神经干细胞分化，软骨形成和成骨，肺表面活性物质生成，肺细胞中层状体的形成。

    Method for using BOC/CDO to modulate hedgehog signaling
    36.
    发明授权
    Method for using BOC/CDO to modulate hedgehog signaling 失效
    使用BOC / CDO调节刺猬信号的方法

    公开(公告)号：US07625759B2

    公开(公告)日：2009-12-01

    申请号：US11625717

    申请日：2007-01-22

    申请人： Frederic J. de Sauvage ,  Hua Tian

    发明人： Frederic J. de Sauvage ,  Hua Tian

    IPC分类号： H01L21/20 ,  A61K38/00

    CPC分类号： C12N5/069 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/392 ,  C12N2501/41 ,  G01N33/57484

    摘要： The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

    摘要翻译： 本发明提供了使用BOC / CDO刺猬蛋白拮抗剂抑制刺猬蛋白信号传导的方法，以及治疗和诊断与刺猬蛋白信号传导或过度表达刺猬的疾病，包括癌症，细胞增殖性疾病和血管发生，神经障碍，以及 作为受刺猬信号传导影响的其他条件，如毛发生长，神经干细胞分化，软骨形成和成骨，肺表面活性物质生成，肺细胞中层状体的形成。

    Nucleic acid encoding novel type-1 cytokine receptor GLM-R
    39.
    发明授权
    Nucleic acid encoding novel type-1 cytokine receptor GLM-R 失效
    编码新型1型细胞因子受体GLM-R的核酸

    公开(公告)号：US07303896B2

    公开(公告)日：2007-12-04

    申请号：US10373512

    申请日：2003-02-24

    申请人： Nico P. Ghilardi ,  Frederic J. de Sauvage ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  William I. Wood

    发明人： Nico P. Ghilardi ,  Frederic J. de Sauvage ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  William I. Wood

    IPC分类号： C12P21/06

    CPC分类号： C07K14/7158

    摘要： The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.

    摘要翻译： 本发明涉及GLM-R多肽的新型多肽及其变体以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 还提供了用于检测调节GLM-R的活性的试剂的方法。 还提供了用于诊断和治疗特征在于单核细胞或巨噬细胞过度或不丰富的疾病的方法。