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公开(公告)号：US5585503A
公开(公告)日：1996-12-17
申请号：US455053
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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公开(公告)号：US5399719A
公开(公告)日：1995-03-21
申请号：US83459
申请日：1993-06-28
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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公开(公告)号：US5139940A
公开(公告)日：1992-08-18
申请号：US427303
申请日：1989-10-26
IPC分类号： B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： C07D493/04 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , Y10S435/81
摘要： The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
摘要翻译： 本发明涉及含有多种替代物的异补骨脂素化合物组合物，其可以与核酸聚合物结合。 激活这些结合的异补骨脂素的反应条件导致与核酸聚合物的共价交联。 所得复合物被抑制为用于互补核酸聚合物的模板定向酶合成的模板。 除了异消消旋体组合物之外，本发明包括它们的合成，核酸复合体的产生和检测以及上述异丙屈肌酸酯的抑制方法。
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公开(公告)号：US06420570B1
公开(公告)日：2002-07-16
申请号：US09767611
申请日：2001-01-22
IPC分类号： C07D49300
CPC分类号： C07D493/04 , A01N1/0215 , A01N43/90 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。
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35.发明授权Method for the photoactivation of 4' and 5' primary aminoalkyl psoralens in platelet preparations 失效4'和5'伯氨基烷基补骨脂素在血小板制剂中的光活化方法
公开(公告)号：US6004741A
公开(公告)日：1999-12-21
申请号：US957307
申请日：1997-10-23
CPC分类号： A61L2/0011 , A01N1/0215 , A01N1/0294 , A61K31/37 , A61K41/0066
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. In particular, 4' and 5' primary aminoalkyl psoralens are photoactivated in platelet preparations to inactivate pathogens.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。 特别地，4'和5'伯氨基烷基补骨脂素在血小板制剂中被光活化以灭活病原体。
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公开(公告)号：US5654443A
公开(公告)日：1997-08-05
申请号：US455955
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。
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37.发明授权Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens 失效使用4'-伯氨基取代的补骨脂素的光活化来灭活血液中的病原体的方法
公开(公告)号：US5593823A
公开(公告)日：1997-01-14
申请号：US337987
申请日：1994-11-14
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C12N7/06
CPC分类号： C07D493/04 , A01N1/0215 , A01N1/0294 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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公开(公告)号：US5578736A
公开(公告)日：1996-11-26
申请号：US456205
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/02
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。
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