公开(公告)号：US20210172937A1

公开(公告)日：2021-06-10

申请号：US17026561

申请日：2020-09-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Kent Johnson ,  Michael Tsionsky ,  John H. Kenten ,  Jeff D. Debad ,  Robert M. Umek ,  Paula Denney Eason ,  Hans Biebuyck ,  Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Niranjan Y. Sardesai

IPC: G01N33/53 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/68 ,  G01N33/569 ,  G01N33/573

Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US10782227B2

公开(公告)日：2020-09-22

申请号：US16845560

申请日：2020-04-10

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

IPC: B01L3/00 ,  B01L9/00 ,  G01N21/76 ,  G01N21/66 ,  G01N21/25 ,  G01N35/04 ,  G01N21/64

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US10539501B2

公开(公告)日：2020-01-21

申请号：US15587968

申请日：2017-05-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

IPC: B01L3/00 ,  B01L9/00 ,  G01N21/76 ,  G01N21/62 ,  G01N21/64 ,  G01N21/66 ,  G01N21/25 ,  G01N35/04

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20190219794A1

公开(公告)日：2019-07-18

申请号：US16360257

申请日：2019-03-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian Chamberlin ,  Charlles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  D.T. Le ,  Aaron Leimkuehler ,  George Sigal ,  Leo Tabakin ,  Jon Willoughby

IPC: G02B7/36 ,  G01N35/02 ,  G01N21/25 ,  G01N21/64

CPC classification number: G02B7/36 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/028

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US10189023B2

公开(公告)日：2019-01-29

申请号：US14203638

申请日：2014-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C07H21/04 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6804 ,  G01N33/68 ,  C12Q1/6816

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20180348217A1

公开(公告)日：2018-12-06

申请号：US16054332

申请日：2018-08-03

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N2800/104 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US09797894B2

公开(公告)日：2017-10-24

申请号：US13956841

申请日：2013-08-01

Applicant: Meso Scale Technologies, LLC

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/53 ,  C12Q1/68 ,  C12M1/34 ,  C40B30/04 ,  G01N27/00 ,  G01N21/66 ,  G01N33/566 ,  G01N33/543

CPC classification number: G01N33/54386 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834 ,  G01N33/5306 ,  G01N2446/00 ,  G01N2458/30

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20140272939A1

公开(公告)日：2014-09-18

申请号：US14206284

申请日：2014-03-12

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/53 ,  G01N33/569

CPC classification number: G01N33/54393 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/56988 ,  G01N33/582 ,  G01N2021/7786 ,  C12Q2537/125 ,  C12Q2563/179

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

Abstract translation: 本发明涉及用于改善结合测定中测定特异性和性能的方法。

公开(公告)号：US20140220007A1

公开(公告)日：2014-08-07

申请号：US14169289

申请日：2014-01-31

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N2800/104 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Abstract translation: 本发明涉及诊断患者狼疮的方法，以及监测狼疮进展的方法和/或监测治疗剂或治疗方案治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。

公开(公告)号：US12216331B2

公开(公告)日：2025-02-04

申请号：US18596909

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Ian D. Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  D. T. Le ,  Aaron Leimkuehler ,  George Sigal ,  Leo Tabakin ,  Jon Willoughby

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.