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40 条记录 (耗时 0.031 秒)

    Optical system and method for optically analyzing light from a sample
    31.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US06927852B2

    公开(公告)日：2005-08-09

    申请号：US10773712

    申请日：2004-02-05

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01N21/64 ,  G01J3/04 ,  G01J3/28 ,  G01N21/03 ,  G01N21/05 ,  G01N21/27 ,  G01N21/31 ,  G01N27/447 ,  G01J3/30

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。

    Methods for fluorescence detection that minimizes undesirable background fluorescence
    32.
    发明授权
    Methods for fluorescence detection that minimizes undesirable background fluorescence 有权
    荧光检测方法，使不需要的背景荧光最小化

    公开(公告)号：US06921908B2

    公开(公告)日：2005-07-26

    申请号：US10833425

    申请日：2004-04-28

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01N21/64 ,  F21V9/16

    CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2021/6495

    摘要： The present invention provides a method for the excitation of a fluorescent sample and the measurement of the fluorescent emission. The method of the present invention has the advantage of significantly reducing the amount of background fluorescence. The method includes the steps of exciting a sample in a substrate with a beam of light that enters the substrate at an angle less than or equal to 45° C., and preferably, less than or equal to 20°, and then collecting the fluorescent emission form the sample with a lens system which focuses the emitted light onto a CCD for detection. Although the following description of the present invention uses a scanning system using channel plates by way of illustration, the method described herein may also be used with non-scanning systems as well as capillary systems.

    摘要翻译： 本发明提供一种激发荧光样品和荧光发射测量的方法。 本发明的方法具有显着减少背景荧光量的优点。 该方法包括以小于或等于45℃，优选小于或等于20°的角度进入衬底的光束激发衬底中的样品的步骤，然后收集荧光 发射形成具有将发射的光聚焦到CCD上以进行检测的透镜系统的样品。 虽然本发明的以下描述使用了使用通道板的扫描系统作为说明，但是本文所述的方法也可以与非扫描系统以及毛细管系统一起使用。

    Time-delay integration in electrophoretic detection systems
    33.
    发明授权
    Time-delay integration in electrophoretic detection systems 有权

    公开(公告)号：US06856390B2

    公开(公告)日：2005-02-15

    申请号：US10205028

    申请日：2002-07-25

    申请人： Eric S. Nordman ,  Richard T. Reel ,  John Shigeura

    发明人： Eric S. Nordman ,  Richard T. Reel ,  John Shigeura

    IPC分类号： G01N21/64 ,  G01N27/447 ,  G01N21/00

    CPC分类号： G01N27/44721

    摘要： An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with non-coherent radiation; a detector array disposed for collecting light signals emitted from markers in the detection zone excited by the radiation, the detector array having an output; and a system coupled to the detector array for effecting time delay integration of the charges on the detector array corresponding to the light signals by accumulating the charges before reading the charges at the output of the detector array. Other apparatus and methods for detecting analytes in a sample are also provided.

    Detection cell for guiding excitation light therein and method for using same
    34.
    发明授权
    Detection cell for guiding excitation light therein and method for using same 有权
    用于引导激发光的检测单元及其使用方法

    公开(公告)号：US06797139B2

    公开(公告)日：2004-09-28

    申请号：US09812750

    申请日：2001-03-19

    申请人： Dar Bahatt ,  Richard T. Reel

    发明人： Dar Bahatt ,  Richard T. Reel

    IPC分类号： B01D5702

    CPC分类号： G01N21/05 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/0346 ,  G01N2021/6482

    摘要： The present invention provides a detection cell that comprises a body having a first end that defines a first opening, a second end that defines a second opening, and an internal surface that defines an interior cavity that fluidly connects the first opening and the second opening; wherein the interior cavity is capable of holding a support matrix for receiving a chemical species through the first opening, passing the chemical species through the interior cavity, and discharging the chemical species through the second opening; and wherein at least two portions of the body are capable of providing a first and a second guiding region each having an index of refraction less than that of the support matrix. A system utilizing the detection cell of the present invention is also provided. In another embodiment, the present invention provides a method for guiding light through a support matrix through which a chemical species is passing.

    摘要翻译： 本发明提供了一种检测单元，其包括具有限定第一开口的第一端，限定第二开口的第二端和限定使第一开口和第二开口流体连接的内部空腔的内表面的主体; 其中所述内部空腔能够保持用于通过所述第一开口接收化学物质的支撑矩阵，使所述化学物质通过所述内部空腔，并且通过所述第二开口排出所述化学物质; 并且其中所述主体的至少两个部分能够提供每个具有小于所述支撑矩阵的折射率的折射率的第一和第二引导区域。 还提供了利用本发明的检测单元的系统。 在另一个实施方案中，本发明提供一种用于引导光通过化学物质通过的载体基质的方法。

    Optical system and method for optically analyzing light from a sample
    37.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US07477381B2

    公开(公告)日：2009-01-13

    申请号：US11548210

    申请日：2006-10-10

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01J3/28

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。

    Optical system and method for optically analyzing light from a sample
    40.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US06690467B1

    公开(公告)日：2004-02-10

    申请号：US09564790

    申请日：2000-05-05

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01J328

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。