公开(公告)号：US20050263985A1

公开(公告)日：2005-12-01

申请号：US10853426

申请日：2004-05-25

Applicant: Steven Miller ,  Mark Reynolds ,  James Eckelberry ,  Robert Carlstedt ,  Daniel Chien ,  Kenneth Lang ,  Martin Peaker ,  Nancy Saxon ,  Jos Timmermans ,  Jeff Lloyd

Inventor： Steven Miller ,  Mark Reynolds ,  James Eckelberry ,  Robert Carlstedt ,  Daniel Chien ,  Kenneth Lang ,  Martin Peaker ,  Nancy Saxon ,  Jos Timmermans ,  Jeff Lloyd

IPC: B60G1/00 ,  B60G5/00 ,  B60G9/02

CPC classification number: B60G9/02 ,  B60G5/00 ,  B60G2200/318 ,  B60G2200/341 ,  B60G2200/342 ,  B60G2204/421

Abstract: A tandem axle suspension assembly includes a pair of walking beams disposed substantially parallel to a vehicle longitudinal axis supporting first and second axles. A link plate is pivotally attached to each of the walking beams and is pivotal about an axis transverse to the longitudinal axis. A first and a second link include pivotal connections between the link plate and a vehicle frame member. Vertical movement of the walking beams causes a corresponding rotation of the link plate to compensate for longitudinal displacement of the pivotal links with the first and second links and minimize longitudinal displacement of the walking beams.

Abstract translation: 串联轴悬架组件包括一对基本平行于支撑第一和第二轴的车辆纵向轴线的步进梁。 连杆板可枢转地附接到每个步进梁上，并且绕横向于纵向轴线的轴线枢转。 第一和第二连杆包括链板与车架构件之间的枢转连接。 步行梁的垂直运动引起连杆板的相应旋转，以补偿枢轴连杆与第一和第二连杆的纵向位移，并使步行梁的纵向位移最小化。

公开(公告)号：US20050187284A1

公开(公告)日：2005-08-25

申请号：US11111105

申请日：2005-04-20

Applicant: Dean Artis ,  David Jackson ,  Thomas Rawson ,  Mark Reynolds ,  Daniel Sutherlin ,  Mark Stanley

Inventor： Dean Artis ,  David Jackson ,  Thomas Rawson ,  Mark Reynolds ,  Daniel Sutherlin ,  Mark Stanley

IPC: A61K31/195 ,  A61K31/403 ,  A61P1/04 ,  A61P1/12 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P15/14 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07C233/25 ,  C07C233/60 ,  C07C233/81 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07C237/42 ,  C07D207/16 ,  C07D207/48 ,  C07D209/88 ,  C07D403/12 ,  C07D405/12 ,  A61K31/401 ,  C07C237/24

CPC classification number: C07D403/12 ,  C07C233/25 ,  C07C233/60 ,  C07C233/81 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07C2601/08 ,  C07C2603/18 ,  C07C2603/32 ,  C07D207/16 ,  C07D207/48 ,  C07D209/88 ,  C07D405/12

Abstract: Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, R1 to R4, m and n are as defined herein. Compounds of the invention bind to α4 integrin receptors and thereby inhibit binding of ligands for α4 integrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with α4 integrins or their ligands.

公开(公告)号：US20050090514A1

公开(公告)日：2005-04-28

申请号：US10884379

申请日：2004-07-02

Applicant: Mark Reynolds ,  Paul Polakis

Inventor： Mark Reynolds ,  Paul Polakis

IPC: A61K31/00 ,  A61K31/16 ,  A61K31/175 ,  A61K31/513 ,  A61K31/66 ,  A61P35/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07D239/22 ,  C07D295/096 ,  C07D295/135 ,  C07D307/58

CPC classification number: C07C233/58 ,  A61K31/00 ,  A61K31/16 ,  A61K31/175 ,  A61K31/513 ,  A61K31/66 ,  C07C233/59 ,  C07C233/60 ,  C07C2601/14 ,  C07C2602/08 ,  C07D239/22 ,  C07D295/096 ,  C07D295/135 ,  C07D307/58

Abstract: Compounds of the disclosure provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases. The disclosure encompasses compounds, analogs, prodrugs, metabolites, and pharmaceutically acceptable salts thereof, pharmaceutical compositions, and methods for prophylaxis and treatment of diseases and other maladies or conditions involving cancer, tumors, and like conditions. The disclosure also provides therapeutic methods including the administration of an effective amount of a compound of the disclosure.

Abstract translation: 本公开的化合物提供对预防和治疗诸如细胞增殖，血管生成或细胞凋亡介导的疾病等疾病或病症有效的组合物。 本公开包括其化合物，类似物，前药，代谢产物及其药学上可接受的盐，药物组合物和预防和治疗涉及癌症，肿瘤等病症和其它疾病或病症的方法。 本公开还提供治疗方法，包括施用有效量的本发明化合物。

公开(公告)号：US06673611B2

公开(公告)日：2004-01-06

申请号：US09866316

申请日：2001-05-25

Applicant: James Thompson ,  Leonid Beigelman ,  James McSwiggen ,  Alexander Karpeisky ,  Laurent Bellon ,  Mark Reynolds ,  Michael Zwick ,  Thale Jarvis ,  Tod Woolf ,  Peter Haeberli ,  Jasenka Matulic-Adamic

Inventor： James Thompson ,  Leonid Beigelman ,  James McSwiggen ,  Alexander Karpeisky ,  Laurent Bellon ,  Mark Reynolds ,  Michael Zwick ,  Thale Jarvis ,  Tod Woolf ,  Peter Haeberli ,  Jasenka Matulic-Adamic

IPC: C12Q168

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/1135 ,  C12N15/1138 ,  C12N2310/15 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/332 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2310/3527

Abstract: This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.

Abstract translation: 本发明涉及具有特异性结构的新化学修饰的核酸分子，其表现出对核酸酶的增加的抗性和增加的对靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。