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    ELECTRICAL STIMULATION THERAPY FOR LOWER URINARY TRACT DYSFUNCTION AND SEXUAL REFLEX DYSFUNCTION
    31.
    发明申请
    ELECTRICAL STIMULATION THERAPY FOR LOWER URINARY TRACT DYSFUNCTION AND SEXUAL REFLEX DYSFUNCTION 审中-公开
    电刺激治疗下尿路性功能障碍和性反射功能障碍

    公开(公告)号：US20150119951A1

    公开(公告)日：2015-04-30

    申请号：US14563677

    申请日：2014-12-08

    Applicant: Medtronic, Inc.

    Inventor： Dwight E. Nelson ,  Xin Su ,  Thaddeus S. Brink ,  Blake A. Hedstrom

    IPC: A61N1/36 ,  A61N1/372

    CPC classification number: A61N1/36132 ,  A61B5/021 ,  A61B5/024 ,  A61B5/4255 ,  A61B5/4368 ,  A61B5/4393 ,  A61N1/08 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36107 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/37247

    Abstract: Electrical stimulation therapy may be delivered to a patient to selectively and independently address different conditions of a pelvic floor disorder of the patient. The conditions of a pelvic floor disorder may include, for example, a lower urinary tract dysfunction (e.g., urinary or fecal incontinence) and sexual dysfunction (e.g., an impaired sexual reflex response to a sexual stimulus). In some examples, a system is configured to selectively deliver a first electrical stimulation therapy that is configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy that is configured to improve a sexual reflex response of the patient to a sexual stimulus, and a third electrical stimulation therapy that is configured to both elicit the inhibitory physiological response from the patient related to voiding and increase a sexual response of the patient to a sexual stimulus.

    Abstract translation: 电刺激治疗可以递送给患者以选择性且独立地解决患者盆底疾病的不同情况。 盆底疾病的状况可能包括例如下尿路功能障碍（例如尿或大便失禁）和性功能障碍（例如，对性刺激的性反射受损）。 在一些示例中，系统被配置为选择性地递送第一电刺激疗法，其被配置为引起患者与排尿相关的抑制性生理反应，第二电刺激治疗被配置为改善患者的性反射反应 性刺激和第三种电刺激疗法，其被配置为既引起来自患者的与排尿相关的抑制性生理反应并且增加患者对性刺激的性反应。

    CORTICAL POTENTIAL MONITORING
    32.
    发明申请
    CORTICAL POTENTIAL MONITORING 有权
    电磁潜能监测

    公开(公告)号：US20140378941A1

    公开(公告)日：2014-12-25

    申请号：US14063919

    申请日：2013-10-25

    Applicant: Medtronic, Inc.

    Inventor： Xin Su ,  Dwight E. Nelson

    IPC: A61N1/36 ,  A61M5/168

    CPC classification number: A61N1/36139 ,  A61B5/0484 ,  A61B5/4255 ,  A61M5/1723 ,  A61N1/36007 ,  A61N1/37241

    Abstract: Techniques, devices, and systems may include screening effective therapies using cortical evoked potentials. In one example, a system may be configured to receive a first sensed cortical evoked potential of a patient that occurred in response to an induced sensation at an anatomical region different from a brain region of the patient and receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves associated with the anatomical region. The electrical stimulation may be at least partially defined by a set of therapy parameter values. The system may also compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential and determine, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region.

    Abstract translation: 技术，设备和系统可能包括使用皮质诱发电位筛选有效的治疗方法。 在一个示例中，系统可以被配置为接收响应于在不同于患者的脑区域的解剖区域处的诱发感觉而发生的患者的第一感测到的皮层诱发电位，并且接收发生的第二感测皮质诱发电位 响应于递送到与解剖区域相关联的一个或多个神经的电刺激。 电刺激可以至少部分地由一组治疗参数值限定。 该系统还可以将第一感测皮质诱发电位的特征的第一值与第二感测皮层诱发电位的特征的第二值进行比较，并且基于比较确定被配置为治疗相关疾病的治疗的功效 与解剖区域。

    Autotitration of therapy using detected electrical activity
    35.
    发明授权
    Autotitration of therapy using detected electrical activity 有权

    公开(公告)号：US12268879B2

    公开(公告)日：2025-04-08

    申请号：US17472139

    申请日：2021-09-10

    Applicant: Medtronic, Inc.

    Inventor： Xin Su ,  Thaddeus S. Brink ,  Dwight E. Nelson

    IPC: A61N1/36 ,  A61B5/388 ,  A61N1/372 ,  G16H20/30

    Abstract: This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters. In one example, a method includes controlling an implantable medical device to deliver electrical stimulation to a patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient, obtaining, by one or more processors and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of an electrical response sensed from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set, and determining, by the one or more processors and based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the implantable medical device.

    Managing therapy delivery based on physiological markers
    37.
    发明授权
    Managing therapy delivery based on physiological markers 有权

    公开(公告)号：US11376438B2

    公开(公告)日：2022-07-05

    申请号：US16663023

    申请日：2019-10-24

    Applicant: Medtronic, Inc.

    Inventor： Thaddeus S. Brink ,  Dwight E. Nelson ,  Xin Su ,  Lance Zirpel

    IPC: A61N1/36 ,  A61B5/20 ,  A61B5/00 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/391

    Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.

    MANAGING THERAPY DELIVERY BASED ON PHYSIOLOGICAL MARKERS
    38.
    发明申请
    MANAGING THERAPY DELIVERY BASED ON PHYSIOLOGICAL MARKERS 有权

    公开(公告)号：US20220105348A1

    公开(公告)日：2022-04-07

    申请号：US17552813

    申请日：2021-12-16

    Applicant: Medtronic, Inc.

    Inventor： Thaddeus S. Brink ,  Dwight E. Nelson ,  Xin Su ,  Lance Zirpel

    IPC: A61N1/36 ,  A61B5/20 ,  A61B5/00

    Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.

    PATIENT STATE DETERMINATION BASED ON ONE OR MORE SPECTRAL CHARACTERISTICS OF A BIOELECTRICAL BRAIN SIGNAL
    39.
    发明申请
    PATIENT STATE DETERMINATION BASED ON ONE OR MORE SPECTRAL CHARACTERISTICS OF A BIOELECTRICAL BRAIN SIGNAL 有权

    公开(公告)号：US20210330234A1

    公开(公告)日：2021-10-28

    申请号：US17366397

    申请日：2021-07-02

    Applicant: Medtronic, Inc.

    Inventor： Dwight E. Nelson ,  Jianping Wu ,  Rahul Gupta ,  Yan Zhao

    IPC: A61B5/316 ,  A61N1/36 ,  A61B5/00 ,  A61B5/374

    Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.

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