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公开(公告)号：US06277576B1
公开(公告)日：2001-08-21
申请号：US09306768
申请日：1999-05-07
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06268150B1
公开(公告)日：2001-07-31
申请号：US09459751
申请日：1999-12-10
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06238870B1
公开(公告)日：2001-05-29
申请号：US09458187
申请日：1999-12-08
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06232295B1
公开(公告)日：2001-05-15
申请号：US08321552
申请日：1994-10-12
IPC分类号： A61K4800
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
摘要翻译： 描述了能够特异性结合并进入目标细胞的递送载体，为细胞的磁共振成像（MRI）递送许多顺磁离子。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和MRI造影剂连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许对核酸递送进行医学成像监测。
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公开(公告)号：US6096273A
公开(公告)日：2000-08-01
申请号：US743798
申请日：1996-11-05
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
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公开(公告)号：US5780234A
公开(公告)日：1998-07-14
申请号：US709263
申请日：1996-09-06
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US20110059535A1
公开(公告)日：2011-03-10
申请号：US12773382
申请日：2010-05-04
IPC分类号： G01N27/02 , C08F290/14
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US20100298415A1
公开(公告)日：2010-11-25
申请号：US12729814
申请日：2010-03-23
IPC分类号： A61K31/7088 , C07H21/04 , C07K14/00 , A61P35/00
CPC分类号： C07K19/00 , A61K31/7135 , C07H23/00
摘要： The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
摘要翻译： 本发明提供目标希夫碱配合物。 特别地，本发明提供了配置成抑制靶向蛋白质活性的生物聚合物靶向过渡金属络合物，其合成方法及其药物组合物及其用途。
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公开(公告)号：US07759073B2
公开(公告)日：2010-07-20
申请号：US12366471
申请日：2009-02-05
IPC分类号： G01N33/53
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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公开(公告)号：US20100038262A1
公开(公告)日：2010-02-18
申请号：US12544682
申请日：2009-08-20
申请人： Thomas J. Meade
发明人： Thomas J. Meade
IPC分类号： G01N27/26
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移过程的核重组能量λ检测分析物的新方法和组合物。
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