利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

184 条记录 (耗时 0.031 秒)

    Coating composition and articles having a cured coating
    31.
    发明授权
    Coating composition and articles having a cured coating 失效
    具有固化涂层的涂料组合物和制品

    公开(公告)号：US5728758A

    公开(公告)日：1998-03-17

    申请号：US635077

    申请日：1996-04-19

    申请人： Robert A. Smith

    发明人： Robert A. Smith

    IPC分类号： C08J7/04 ,  C09D129/04 ,  C09D183/04 ,  G02B1/10 ,  G02B5/23 ,  C08L29/04 ,  C08L43/04

    CPC分类号： C08J7/047 ,  C09D129/04 ,  C09D183/04 ,  G02B1/105 ,  G02B5/23 ,  C08J2483/00 ,  Y10T428/31507 ,  Y10T428/31598 ,  Y10T428/31663 ,  Y10T428/31667

    摘要： Describes a coating composition for the preparation of abrasion resistant coatings consisting essentially of: (a) 5 to 35 weight percent of a silane monomer mixture of (i) C.sub.1 -C.sub.12 alkyl tri(C.sub.1 -C.sub.6)alkoxysilane and (ii) tetra(C.sub.1 -C.sub.6)alkoxysilane, the weight ratio of (i) to (ii) being from 3:1 to 1:3; (b) 1 to 9 weight percent of polyvinyl alcohol that is at least 72 percent hydrolyzed; (c) a solvating amount of lower aliphatic alcohol; (d) a catalytic amount of water-soluble acid; (e) a leveling amount of nonionic surfactant; and (f) water in an amount sufficient to form hydrolysates of the silane monomers and to solubilize the polyvinyl alcohol and acid. Further described are transparent articles and photochromic articles comprising organic polymeric host material, organic photochromic compound(s), and a cured abrasion resistant coating prepared from the coating composition.

    摘要翻译： 描述了用于制备耐磨涂层的涂料组合物，其基本上由以下组成：（a）5-35重量％的（i）C 1 -C 12烷基三（C 1 -C 6）烷氧基硅烷和（ii）四（C 1 -C 6）烷氧基硅烷的硅烷单体混合物 -C 6）烷氧基硅烷，（i）至（ii）的重量比为3：1至1：3; （b）1至9重量％的至少72％水解的聚乙烯醇; （c）溶剂化的低级脂族醇; （d）催化量的水溶性酸; （e）非离子表面活性剂的调配量; 和（f）水的量足以形成硅烷单体的水解产物并溶解聚乙烯醇和酸。 还描述了包含有机聚合物主体材料，有机光致变色化合物和由涂料组合物制备的固化的耐磨涂层的透明制品和光致变色制品。

    Glucagon antagonists and methods relating thereto
    33.
    发明授权
    Glucagon antagonists and methods relating thereto 失效
    胰高血糖素拮抗剂及其相关方法

    公开(公告)号：US5508304A

    公开(公告)日：1996-04-16

    申请号：US288875

    申请日：1994-08-10

    申请人： Robert R. West ,  Virender Labroo ,  James R. Piggott ,  Robert A. Smith ,  Patricia A. McKernan

    发明人： Robert R. West ,  Virender Labroo ,  James R. Piggott ,  Robert A. Smith ,  Patricia A. McKernan

    IPC分类号： A61K31/12 ,  A61K31/122 ,  A61K31/22 ,  A61K31/27 ,  C12P15/00 ,  A61K31/21

    CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K31/22 ,  A61K31/27 ,  C12P15/00

    摘要： Glucagon antagonists and methods relating thereto are disclosed. The glucagon antagonists include skyrin and skyrin analogs, and serve to inhibit the stimulation of a glucagon-induced response pathway, such as the adenylate cyclase response pathway or the inositol phosphate response pathway. The glucagon antagonists may be used within therapeutic compositions to treat disease states associate with elevated glucose levels, including diabetes and hyperglycemia. The present invention also discloses a biologically pure culture of ATCC accession number 74200, as well as methods relating to the production of glucagon antagonists by cultivating the same in a nutrient medium and recovering the glucagon antagonist therefrom.

    摘要翻译： 公开了胰高血糖素拮抗剂及其相关方法。 胰高血糖素拮抗剂包括天冬氨酸和天冬氨酸类似物，并且用于抑制胰高血糖素诱导的应答途径的刺激，例如腺苷酸环化酶应答途径或肌醇磷酸应答途径。 胰高血糖素拮抗剂可用于治疗组合物内以治疗与升高的葡萄糖水平相关的疾病状态，包括糖尿病和高血糖。 本发明还公开了ATCC保藏号74200的生物纯纯培养物，以及通过在营养培养基中培养并从其中回收胰高血糖素拮抗剂来产生胰高血糖素拮抗剂的方法。

    Methods for detecting glucagon antagonists
    34.
    发明授权
    Methods for detecting glucagon antagonists 失效
    检测胰高血糖素拮抗剂的方法

    公开(公告)号：US5408037A

    公开(公告)日：1995-04-18

    申请号：US741931

    申请日：1991-08-08

    申请人： Robert A. Smith ,  James R. Piggott

    发明人： Robert A. Smith ,  James R. Piggott

    IPC分类号： C07K14/575 ,  C07K14/605 ,  C12N1/19 ,  C12N15/09 ,  C12N15/16 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  A61K37/00 ,  C07K7/00

    CPC分类号： C07K14/605

    摘要： Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.

    摘要翻译： 提供了通过使用重组DNA技术检测胰高血糖素拮抗剂的方法。 简而言之，在合适的宿主细胞内表达胰高血糖素类似物之后，类似物暴露于在天然胰高血糖素存在下偶联至应答途径的胰高血糖素受体。 由胰高血糖素类似物与胰高血糖素受体的结合引起的反应途径的刺激相对于单独的天然胰高血糖素刺激反应途径的降低表明存在胰高血糖素拮抗剂。 还提供了通过该方法鉴定和分离的胰高血糖素拮抗剂。

    Fast curing rubber blend
    35.
    发明授权
    Fast curing rubber blend 失效
    快速固化橡胶混合物

    公开(公告)号：US5162425A

    公开(公告)日：1992-11-10

    申请号：US590260

    申请日：1990-09-28

    申请人： Paul H. Sandstrom ,  Emil M. Friedman ,  J. Dale Massie, II ,  Robert A. Smith

    发明人： Paul H. Sandstrom ,  Emil M. Friedman ,  J. Dale Massie, II ,  Robert A. Smith

    IPC分类号： C08L21/00

    CPC分类号： C08L21/00 ,  C08L9/00 ,  C08L9/06

    摘要： It is highly desirable to be able to cure rubbers quickly since the amount of energy required for the curing process is reduced and the number of articles that can be cured in a mold in a given time is increased. In other words, the cycle time needed to cure articles made from such a rubber is reduced and the throughput of a mold utilized in curing such a rubber is increased. Unfortunately, most attempts to accelerate the cure rate of rubber have resulted in the rubber having poor scorch safety. The present invention discloses a fast curing rubber blend having excellent scorch safety which comprises: (a) from 50 to 98 weight percent of at least one polydiene rubber, and (b) from 2 to 50 weight percent of at least one vinylpyridine copolymer comprised of repeat units which are derived from a diene monomer and vinylpyridine wherein from 1 to 75 weight percent of the repeat units in said copolymer are derived from vinylpyridine. The rubber blends of the present invention have unexpectedly been shown to have particular utility in improving tire tread traction.

    摘要翻译： 由于固化过程所需的能量的量减少并且在给定时间内可以在模具中固化的制品的数量增加，所以非常希望能够快速地固化橡胶。 换句话说，固化由这种橡胶制成的制品所需的循环时间减少，并且用于固化这种橡胶的模具的生产量增加。 不幸的是，大多数加速橡胶固化速度的尝试导致橡胶具有差的焦烧安全性。 本发明公开了一种具有优异的焦烧安全性的快速固化橡胶共混物，其包括：（a）50至98重量％的至少一种聚二烯橡胶，和（b）2至50重量％的至少一种乙烯基吡啶共聚物， 衍生自二烯单体和乙烯基吡啶的重复单元，其中所述共聚物中1至75重量％的重复单元衍生自乙烯基吡啶。 本发明的橡胶混合物意外地被证明在改善轮胎胎面牵引力方面具有特别的用途。

    Preparation of polymers containing pendant isocyanate groups and derivatives thereof by emulsion copolymerization
    38.
    发明授权
    Preparation of polymers containing pendant isocyanate groups and derivatives thereof by emulsion copolymerization 失效
    通过乳液共聚制备含异氰酸酯侧基的聚合物及其衍生物

    公开(公告)号：US4694057A

    公开(公告)日：1987-09-15

    申请号：US708840

    申请日：1985-03-06

    申请人： Robert A. Smith ,  Dane K. Parker ,  Howard A. Colvin ,  Arthur H. Weinstein ,  Dennis B. Patterson

    发明人： Robert A. Smith ,  Dane K. Parker ,  Howard A. Colvin ,  Arthur H. Weinstein ,  Dennis B. Patterson

    IPC分类号： C08F12/00 ,  C08F2/22 ,  C08F2/24 ,  C08F12/26 ,  C08F212/14 ,  C08F220/42 ,  C08F220/44 ,  C08F236/10 ,  C08G18/72

    CPC分类号： C08G18/728 ,  C08F212/14

    摘要： It has unexpectedly been discovered that 1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl) benzene(m-TMI) can be emulsion copolymerized with other monomers into useful polymers. For example, it has been found that m-TMI can be emulsion copolymerized with diene monomers to produce polymers which contain pendant isocyanate groups. Such pendant isocyanate groups are useful in a variety of applications. For instance, such pendant isocyanate groups can be utilized as sites to which chemical agents, such as antidegradants, can be bound to the polymer. Elastomers which contain such pendant isocyanate groups are of value since they can be crosslinked without employing sulfur. Elastomers of this type which contain pendant isocyanate groups can also potentially be thermo-reversibly crosslinked.

    摘要翻译： 意外地发现1-（1-异氰酸基-1-甲基乙基）-3-（1-甲基乙烯基）苯（m-TMI）可以与其它单体乳液共聚成有用的聚合物。 例如，已经发现，m-TMI可以与二烯单体乳液共聚以制备含异氰酸酯侧基的聚合物。 这种侧挂异氰酸酯基可用于各种应用。 例如，这种异氰酸酯侧基可用作化学试剂如抗降解剂可以结合到聚合物上的位点。 含有这种异氰酸酯侧基的弹性体是有价值的，因为它们可以交联而不使用硫。 含有异氰酸酯侧基的这种类型的弹性体也可能是热可逆交联的。

    Liquid crystal materials and devices containing them
    39.
    发明授权
    Liquid crystal materials and devices containing them 失效
    液晶材料和含有它们的装置

    公开(公告)号：US4253740A

    公开(公告)日：1981-03-03

    申请号：US940758

    申请日：1978-09-08

    申请人： Edward P. Raynes ,  Robert A. Smith

    发明人： Edward P. Raynes ,  Robert A. Smith

    IPC分类号： C09K19/42 ,  C09K19/44 ,  C09K19/46 ,  C09K19/48 ,  C09K19/50 ,  G02F1/13 ,  C09K3/34

    CPC分类号： C09K19/42 ,  C09K19/48

    摘要： A liquid crystal material having a low threshold voltage for use in displays comprises a mixture of at least three liquid cyrstal materials at least two of which are selected from the following compounds. ##STR1## or the above compounds where in a cyclo hexane ring is substituted for one of the benzene rings, where X is a short alkyl group C.sub.n H.sub.2n+1 and n is an even integer, or where X is a short alkoxy group C.sub.m H.sub.2m+1 and m is an odd integer.

    摘要翻译： 具有用于显示器的低阈值电压的液晶材料包括至少三种液态硅胶材料的混合物，其中至少两种液体材料选自下列化合物。 或者上述化合物，其中在环己烷环中取代一个苯环，其中X是短烷基C n H 2n + 1，n是偶数整数，或其中X是短烷氧基 CmH2m + 1，m是奇整数。