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49 条记录 (耗时 0.037 秒)

    Intravitreal injection device and system
    31.
    发明申请
    Intravitreal injection device and system 有权
    玻璃体内注射装置和系统

    公开(公告)号：US20100100054A1

    公开(公告)日：2010-04-22

    申请号：US12456439

    申请日：2009-06-16

    申请人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    发明人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    IPC分类号： A61M5/32

    CPC分类号： A61F9/0017 ,  A61M5/24 ,  A61M5/46 ,  A61M2005/2407 ,  A61M2005/2488

    摘要： An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

    摘要翻译： 一种玻璃体内注射系统，用于向眼睛的玻璃体腔内施用药物制剂，其包含（i）与适于在其中接受和容纳其药理学制剂的内部制剂室耦合或包含的注射构件（ii） ）具有与制剂室和第二注射端连通的第一端的针，以及（iii）用于将系统定位在眼睛上的引导针，并且将针的穿入深度限制到 眼。

    Stable Therapeutic Formulations
    32.
    发明申请
    Stable Therapeutic Formulations 有权
    稳定的治疗配方

    公开(公告)号：US20070184096A1

    公开(公告)日：2007-08-09

    申请号：US11617639

    申请日：2006-12-28

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    IPC分类号： A61K48/00 ,  A61K9/70 ,  A61K31/716

    CPC分类号： A61K9/0021 ,  A61K9/703 ,  A61K31/716 ,  A61K38/2242 ,  A61K38/29 ,  A61K48/00 ,  A61K2039/54 ,  A61M37/0015 ,  A61M2037/0023 ,  B65B7/02 ,  B65B31/00 ,  B65B51/10 ,  B65B55/00 ,  B65D81/20 ,  B65D81/266 ,  Y02A50/471 ,  Y02A50/478

    摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

    摘要翻译： 用于配制和递送具有增强的物理稳定性的生物活性剂制剂的组合物和方法，并且其中由氧和/或水的存在引起的劣化被最小化和/或控制，以产生稳定的制剂。 用于配制和递送本发明的生物活性剂的组合物和方法进一步促进它们掺入生物相容性涂层中，所述生物相容性涂层可用于涂覆角质层刺穿的微喷射体，或多个角质层刺穿的输送装置的微突出物 ，用于通过受试者的皮肤递送生物相容性涂层，从而提供递送生物活性剂的有效手段。

    Microprojection array immunization patch and method
    33.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20060074377A1

    公开(公告)日：2006-04-06

    申请号：US11267563

    申请日：2005-11-04

    申请人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    IPC分类号： A61B17/20 ,  A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥，并使用冲击施加器施用于待接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

    Apparatus and method for transdermal delivery of fentanyl-based agents
    35.
    发明申请
    Apparatus and method for transdermal delivery of fentanyl-based agents 审中-公开
    用于透皮递送芬太尼基药剂的装置和方法

    公开(公告)号：US20050226922A1

    公开(公告)日：2005-10-13

    申请号：US11084636

    申请日：2005-03-18

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61M37/00

    CPC分类号： A61K9/0021 ,  A61K31/445 ,  A61M37/0015 ,  A61M2037/0023

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于芬太尼的药剂包含在施加到微突出物构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有含有基于芬太尼的药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于芬太尼的药剂包含在包衣和水凝胶制剂中。

    Peptidically buffered formulations for electrotransport applications and methods of making
    37.
    发明申请
    Peptidically buffered formulations for electrotransport applications and methods of making 审中-公开
    用于电转运应用的肽缓冲制剂和制备方法

    公开(公告)号：US20050142531A1

    公开(公告)日：2005-06-30

    申请号：US10993649

    申请日：2004-11-19

    申请人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    发明人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    IPC分类号： A01N1/00 ,  A61K9/00 ,  A61K31/74 ,  A61N1/30

    CPC分类号： A61N1/0448 ,  A61K9/0095 ,  A61N1/0412

    摘要： Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.

    摘要翻译： 制备用于电转运系统的组合物的方法。 该方法包括提供包含药物离子和相关联的抗衡离子的药物溶液; 首先通过使药液与离子交换材料接触来调节药液的pH值; 将离子交换材料与pH调节药液分离; 并用缓冲液缓冲pH调节的药物溶液。 优选使用肽缓冲剂。 该方法导致组合物适用于电转运递送系统。