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    Blood analysis device and blood analysis system using the same
    31.
    发明授权
    Blood analysis device and blood analysis system using the same 失效
    血液分析装置和血液分析系统使用相同

    公开(公告)号：US08529472B2

    公开(公告)日：2013-09-10

    申请号：US12675994

    申请日：2008-09-04

    申请人： Keisuke Matsumura ,  Masaki Fujiwara

    发明人： Keisuke Matsumura ,  Masaki Fujiwara

    IPC分类号： A61B5/00 ,  B65D81/00

    CPC分类号： A61B5/151 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150954 ,  A61B5/15109 ,  A61B5/15134 ,  A61B5/15138 ,  A61B5/157 ,  A61B2562/0295

    摘要： A blood analysis device wherein a carrying part blood attached thereto can be localized to thereby facilitate handling after using. When incorporating blood collected from the punctured skin, the blood is held in a skin-puncturing device or the like so that an uncontaminated holding area can be enlarged and the degree of freedom in handling can be increased. A blood analysis device which comprises a plate type device body having a blood collection port for incorporating blood and a ventilation hole formed at a certain distance apart in a face and a passage located inside for connecting the blood collection port to the ventilation hole, and a blood analysis section located within the passage for analyzing the blood having been incorporated via the blood collection port.

    摘要翻译： 血液分析装置，其中附着于其上的携带部分血液可以被定位，从而便于使用后的处理。 当将从穿刺皮肤收集的血液结合时，将血液保持在皮肤穿刺装置等中，使得可以扩大未受污染的保持区域，并且可以提高处理的自由度。 一种血液分析装置，其特征在于，包括具有用于引入血液的血液采集口和在面部隔开一定距离处形成的通气孔和位于内部的用于将血液采集口连接到通气孔的板状装置体， 位于通道内的血液分析部分，用于分析通过血液采集口并入的血液。

    BIOSENSOR, THIN FILM ELECTRODE FORMING METHOD, QUANTIFICATION APPARATUS, AND QUANTIFICATION METHOD
    34.
    发明申请
    BIOSENSOR, THIN FILM ELECTRODE FORMING METHOD, QUANTIFICATION APPARATUS, AND QUANTIFICATION METHOD 有权
    生物传感器，薄膜电极形成方法，量化装置和定量方法

    公开(公告)号：US20120251708A1

    公开(公告)日：2012-10-04

    申请号：US13490553

    申请日：2012-06-07

    申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

    发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

    IPC分类号： H05K13/04 ,  B05D5/12 ,  B23K26/38 ,  C23C14/34

    CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

    摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

    摘要翻译： 公开了一种生物传感器，其包括支撑件; 由诸如金或钯等贵金属的导电材料和碳组成的导电层; 平行于和垂直于支撑体侧面的狭缝; 工作，计数器和检测电极; 覆盖支架上的工作电极，反电极和检测电极的间隔件; 在间隔件中形成矩形切口，形成试样供应路径; 样品供应路径的入口; 通过将含有酶的试剂施加到通过所述间隔件中的切口暴露的所述工作，反向和检测电极而形成的试剂层; 和间隔物上的盖子。 可以通过简单的方法形成生物传感器，并且不管试剂组成如何，在电极上提供均匀的试剂层。

    Method of measuring hematocrit (Hct), sensor used in the method, and measuring device
    38.
    发明授权
    Method of measuring hematocrit (Hct), sensor used in the method, and measuring device 有权
    测量血细胞比容（Hct），方法中使用的传感器和测量装置的方法

    公开(公告)号：US08088271B2

    公开(公告)日：2012-01-03

    申请号：US10578988

    申请日：2004-12-03

    申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

    发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

    IPC分类号： G01N27/26 ,  G01N33/487

    CPC分类号： G01N27/3274

    摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.

    摘要翻译： 本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。 电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质 在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。 检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。

    Biosensor, thin film electrode forming method, quantification apparatus, and quantification method
    39.
    发明申请
    Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
    生物传感器，薄膜电极形成方法，定量装置和定量方法

    公开(公告)号：US20110278167A1

    公开(公告)日：2011-11-17

    申请号：US13135848

    申请日：2011-07-15

    申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

    发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

    摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.

    摘要翻译： 根据本发明的生物传感器包括支撑体1，由诸如金，钯等的诸如贵金属的导电材料构成的导电层2和碳，平行于载体侧的狭缝3a和3b 如图1所示，与支撑体1侧垂直的狭缝4a，4b，工作电极5，对电极6，检测电极7，覆盖工作电极5的间隔件8，对置电极6和检测电极7 支撑体1，形成试样供给路径的矩形切口部9，试料供给路径的入口9a，通过将包含酶等的试剂涂布在工作电极5上而形成的试剂层12，对电极6和 从间隔件8的切口部9暴露的检测电极7和覆盖间隔件8的盖13，如图1所示。 如此构造的生物传感器可以通过简单的方法形成，并且测量精度优异的生物传感器以及试剂层均匀地放置在电极上而不考虑试剂液体组成的生物传感器，并且其中 具有统一的性能可以实现。

    METHOD FOR MEASURING TEMPERATURE OF BIOLOGICAL SAMPLE, METHOD FOR MEASURING CONCENTRATION OF BIOLOGICAL SAMPLE, SENSOR CHIP AND BIOSENSOR SYSTEM
    40.
    发明申请
    METHOD FOR MEASURING TEMPERATURE OF BIOLOGICAL SAMPLE, METHOD FOR MEASURING CONCENTRATION OF BIOLOGICAL SAMPLE, SENSOR CHIP AND BIOSENSOR SYSTEM 有权
    测定生物样本温度的方法，生物样品浓度测定方法，传感器芯片和生物传感器系统

    公开(公告)号：US20110272294A1

    公开(公告)日：2011-11-10

    申请号：US13144790

    申请日：2010-01-28

    申请人： Masaki Fujiwara

    发明人： Masaki Fujiwara

    IPC分类号： G01N27/416

    CPC分类号： G01N27/3274 ,  B01L3/502 ,  B01L2200/147 ,  B01L2300/0645 ,  B01L2400/0406 ,  C12Q1/004 ,  C12Q1/006 ,  C12Q1/54 ,  G01K7/00 ,  G01N27/26 ,  G01N27/28 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/416 ,  Y10T436/144444

    摘要： A sensor chip (200) is configured to measure the temperature of a blood sample and includes a capillary section (40) and an electrode unit (11, 12). The capillary section (40) allows the blood sample to be introduced therein. The electrode unit (11, 12) is configured to measure the temperature of the blood sample and includes a working electrode and a counter electrode. The working electrode and the counter electrode respectively include a reaction reagent layer (20) containing an electrolyte. Further, the electrode unit (11, 12) is configured to receive a predetermined voltage to be applied in measuring the temperature of the blood sample for allowing a result of the measurement to be less affected by increase and reduction in a glucose concentration and the like.

    摘要翻译： 传感器芯片（200）被配置为测量血液样本的温度，并且包括毛细管部分（40）和电极单元（11,12）。 毛细管部分（40）允许将血液样品引入其中。 电极单元（11,12）被配置为测量血液样本的温度，并且包括工作电极和对电极。 工作电极和对电极分别包括含有电解质的反应试剂层（20）。 此外，电极单元（11,12）被配置为在测量血液样本的温度时接受预定的电压以允许测量结果受到葡萄糖浓度等的增加和降低的影响较小 。