公开(公告)号：US20140004185A1

公开(公告)日：2014-01-02

申请号：US13988968

申请日：2011-11-28

Applicant: Nthato Chirwa ,  Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit

Inventor： Nthato Chirwa ,  Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit

IPC: A61K39/395 ,  A61K39/44 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745

CPC classification number: A61K39/39558 ,  A61K9/0024 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K39/44 ,  A61K47/6907 ,  C07K16/3092

Abstract: A pharmaceutical composition for intraperitoneal delivery of an anti-neoplastic agent is provided for treating cancers associated with aberrant mucin expression, preferably ovarian cancer and pancreatic, prostate, metastatic breast, bladder and lung cancers. The composition comprises nanomicelles loaded with the anti-neoplastic agent, and antibodies such as anti-MUC16, anti-MUC1 or anti-MUC4 are conjugated to these nanomicelles. The antibody-bound nanomicelles are optionally embedded in a biodegradable pH- and thermo-responsive hydrogel capable of sol-gel transition at body temperature. The pharmaceutical composition is implantable in the peritoneum, where it transforms into a semi-solid gel at the body's core temperature. In response to pH, the hydrogel swells and releases the antibody-bound nanomicelles. The nanomicelles specifically target mucin antigens on cancer cells. The anti-mucin antibodies can be internalized by the tumour cells, enabling the drug-loaded nanomicelles to gain entry and deliver the chemotherapeutic drugs inside the tumour cell.

Abstract translation: 提供用于腹膜内递送抗肿瘤剂的药物组合物用于治疗与异常粘蛋白表达相关的癌症，优选卵巢癌和胰腺，前列腺，转移性乳腺，膀胱和肺癌。 组合物包含负载有抗肿瘤剂的纳米胶囊，抗体如抗MUC16，抗-MUC1或抗-MUC4与这些纳米胶束缀合。 抗体结合的纳米胶囊任选地嵌入能够在体温下溶胶 - 凝胶转变的可生物降解的pH和热响应性水凝胶中。 药物组合物可植入腹膜中，其在身体核心温度下转化为半固体凝胶。 响应于pH，水凝胶溶胀并释放抗体结合的纳米胶束。 纳米胶囊特异性靶向癌细胞上的粘蛋白抗原。 抗粘蛋白抗体可以被肿瘤细胞内化，使载药纳米胶囊能够进入肿瘤细胞内并输送化学治疗药物。

公开(公告)号：US20140003438A1

公开(公告)日：2014-01-02

申请号：US13538576

申请日：2012-06-29

Applicant: Pradeep Kumar

Inventor： Pradeep Kumar

IPC: H04L12/56

CPC classification number: H04L47/34 ,  H04L1/1628 ,  H04L1/1642 ,  H04L1/1671 ,  H04L1/1809

Abstract: Methods, systems, and computer readable media for updating sequence and acknowledgment numbers associated with replay packets are disclosed. In one example, a method includes generating, at a sending peer node, a replay packet that includes a payload associated with a capture file packet and accessing, in the sending peer node, a sequence-differential (SEQ-DIFF) list using an original sequence number associated with the replay packet. The method further includes traversing entries in the SEQ-DIFF list, wherein each of the entries includes a sequence number and a payload length differential value, applying, for each traversed entry in the SEQ-DIFF list, the payload length differential value to the original sequence number to determine an updated sequence number for the replay packet, and transmitting, from the sending peer node to a receiving peer node, the replay packet that includes the updated sequence number.

Abstract translation: 公开了用于更新与重放分组相关联的序列和确认号码的方法，系统和计算机可读介质。 在一个示例中，一种方法包括在发送对等节点处生成包括与捕获文件分组相关联的有效载荷的重播分组，并且在发送对等节点中使用原始数据访问序列差分（SEQ-DIFF）列表 与重播数据包相关联的序列号。 所述方法还包括遍历SEQ-DIFF列表中的条目，其中每个条目包括序列号和有效载荷长度差分值，对于SEQ-DIFF列表中的每个遍历条目，将有效载荷长度差值应用于原始 序列号，以确定用于重放分组的更新的序列号，以及从发送对等节点向接收对等节点发送包括更新的序列号的重播分组。

公开(公告)号：US08620299B2

公开(公告)日：2013-12-31

申请号：US12190564

申请日：2008-08-12

Applicant: Pradeep Kumar

Inventor： Pradeep Kumar

IPC: H04M15/00 ,  G06F17/00

CPC classification number: G06Q20/02 ,  G06Q20/20 ,  G06Q20/28 ,  G06Q20/32 ,  G06Q20/3227 ,  G06Q20/327 ,  G06Q20/351 ,  G06Q30/02 ,  G06Q30/06 ,  G06Q40/02 ,  H04W12/04

Abstract: Methods, systems, and computer readable media for electronically delivering a prepaid card to a mobile device are disclosed. According to one aspect, the method includes receiving, at a merchant server, purchase information related to the purchase of an electronic prepaid card. The method further includes receiving, from the merchant server, electronic prepaid card information derived from the purchase information. The method further includes establishing a communications link with a mobile device associated with address data included in the electronic prepaid card information. The method also includes provisioning the electronic prepaid card information on the mobile device via over the air (OTA) communications.

Abstract translation: 公开了用于将预付卡电子地传送到移动设备的方法，系统和计算机可读介质。 根据一个方面，该方法包括在商家服务器处接收与购买电子预付卡有关的信息。 该方法还包括从商家服务器接收从购买信息导出的电子预付卡信息。 该方法还包括与包括在电子预付卡信息中的地址数据相关联的移动设备建立通信链路。 该方法还包括通过空中（OTA）通信在移动设备上提供电子预付卡信息。

公开(公告)号：US08513206B2

公开(公告)日：2013-08-20

申请号：US12181798

申请日：2008-07-29

Applicant: Kailash Chand Gupta ,  Pradeep Kumar ,  Archana Shami ,  Atul Pathak

Inventor： Kailash Chand Gupta ,  Pradeep Kumar ,  Archana Shami ,  Atul Pathak

IPC: A61K48/00 ,  A61K9/50

CPC classification number: A61K31/7088 ,  A61K9/5146 ,  A61K48/00 ,  C08G73/0206 ,  C12N15/87

Abstract: The present invention relates to a novel crosslinked polyethylenimine (PEI) nanoparticle based nucleic acid transfection agent wherein the crosslinker is having carbon chain in the range of C2 to C8, ranging between 3.27-19.8%, having the size of nanoparticle ranging between 20-600 nm and zeta potential ranging from +5 to 50 mV.

Abstract translation: 本发明涉及基于新型交联聚乙烯亚胺（PEI）纳米颗粒的核酸转染剂，其中交联剂具有在C2至C8范围内的碳链，范围在3.27-19.8％之间，纳米颗粒的尺寸范围在20-600之间 nm和zeta电位范围为+5至50mV。

公开(公告)号：US20090261172A1

公开(公告)日：2009-10-22

申请号：US12105778

申请日：2008-04-18

Applicant: Pradeep Kumar ,  Ming-Li Liu ,  Roshan Vijayshankar ,  Philippe Martin

Inventor： Pradeep Kumar ,  Ming-Li Liu ,  Roshan Vijayshankar ,  Philippe Martin

IPC: G06K19/067

CPC classification number: H04L9/088 ,  H04L9/0838 ,  H04L63/0853 ,  H04L2209/80 ,  H04W4/80 ,  H04W12/02 ,  H04W12/08

Abstract: Systems, methods, and computer program products for supporting multiple contactless applications using different security keys on a wireless smart device are disclosed. According to one aspect, the subject matter described herein includes a method for supporting multiple contactless applications using different security keys on a wireless smart device. The method includes, at a wireless smart device configured to communicate with a wireless smart device reader, the wireless device including a plurality of contactless applications and a contactless application memory for use by the plurality of contactless applications, initializing a portion of the memory such that access to the portion of memory requires the use of a shared secret key known to the plurality of contactless applications. The method includes reserving the portion of memory for use by one of the plurality of contactless applications by using the shared secret key to set access privileges for the portion of memory such that access to the portion of memory requires the use of a application-specific secret key associated with the one application and not known to the other applications.

Abstract translation: 公开了用于在无线智能设备上使用不同安全密钥来支持多个非接触式应用的系统，方法和计算机程序产品。 根据一个方面，本文描述的主题包括一种在无线智能设备上支持使用不同安全密钥的多个非接触式应用的方法。 该方法包括在被配置为与无线智能设备读取器进行通信的无线智能设备中，该无线设备包括多个非接触式应用和非接触式应用存储器，供多个非接触式应用使用，初始化存储器的一部分，使得 对存储器部分的访问需要使用多个非接触应用已知的共享秘密密钥。 该方法包括通过使用共享秘密密钥来为存储器的该部分设置访问特权来保留存储器的一部分供多个非接触式应用中的一个使用，使得对该部分存储器的访问需要使用特定应用程序的秘密 密钥与一个应用程序相关联，并且不被其他应用程序所知。

公开(公告)号：US20080146462A1

公开(公告)日：2008-06-19

申请号：US11645112

申请日：2006-12-26

Applicant: Kailash Chand Gupta ,  Pradeep Kumar ,  Shweta Mahajan

Inventor： Kailash Chand Gupta ,  Pradeep Kumar ,  Shweta Mahajan

IPC: C40B50/18 ,  C40B50/14

CPC classification number: B01J19/0046 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637

Abstract: The present invention lies in developing a novel method for the preparation of oligonucleotide microarrays obviating the drawbacks to an extent, such as time consuming complex chemical reactions, preparation of modified supports/oligomer modifying reagents, use of activating/condensing reagent, low signal to noise ratio, poor immobilization and hybridization efficiencies, etc. Further, the prepared arrays can be used to detect single or multiple nucleotide mismatches using hybridization assay.

Abstract translation: 本发明在于开发一种制备寡核苷酸微阵列的新方法，其消除了复杂化学反应耗时的缺点，修饰的载体/寡聚体修饰试剂的制备，活化/冷凝试剂的使用，低信噪比 比例，固定化和杂交效率差等。此外，制备的阵列可用于使用杂交测定法检测单核苷酸或多核苷酸错配。

公开(公告)号：US20080056241A1

公开(公告)日：2008-03-06

申请号：US11890016

申请日：2007-08-03

Applicant: Justin Haddad ,  Pradeep Kumar ,  Richard Schmidt

Inventor： Justin Haddad ,  Pradeep Kumar ,  Richard Schmidt

IPC: H04L12/66

CPC classification number: H04L29/06027 ,  H04L12/14 ,  H04L12/1403 ,  H04L65/1006 ,  H04L65/1069 ,  H04M3/2218

Abstract: A unified session detail records of a multi-hop session is provided. The multi-hop session may be established through multiple nodes in a VoIP network. Each node may generate session detail records for the legs of the multi-hop session that are connected to the node. The nodes on the path of the multi-hop call may send the record to a single node to consolidate the session detail records of the legs of the multi-hop call in the single node so that the single node can provide unified session detail records of the multi-hop session. By providing unified session detail records, the user does not need to track down the nodes that are on the path of the multi-hop call to obtain the session detail records of the multi-hop session.

Abstract translation: 提供了多跳会话的统一会话详细记录。 可以通过VoIP网络中的多个节点来建立多跳会话。 每个节点可以生成连接到节点的多跳会话的分支的会话细节记录。 多跳呼叫路径上的节点可以将记录发送到单个节点，以在单个节点中合并多跳呼叫的分支的会话详细记录，使得单个节点可以提供统一的会话详细记录 多跳会话。 通过提供统一的会话详细记录，用户不需要跟踪多跳呼叫路径上的节点，以获取多跳会话的会话详细记录。

公开(公告)号：US20060135759A1

公开(公告)日：2006-06-22

申请号：US11014411

申请日：2004-12-16

Applicant: Pradeep Kumar ,  Kailash Gupta

Inventor： Pradeep Kumar ,  Kailash Gupta

IPC: C07H21/00 ,  C08G63/91

CPC classification number: C07H21/00 ,  Y02P20/582

Abstract: Present invention provides a reusable universal polymer support for repetitive Oligonucleotide synthesis and a method of synthesis thereof.

Abstract translation: 本发明为重复的寡核苷酸合成提供了可重复使用的通用聚合物载体及其合成方法。

公开(公告)号：US06376683B1

公开(公告)日：2002-04-23

申请号：US09872849

申请日：2001-06-01

Applicant: Pradeep Kumar ,  Rodney Agustinho Fernandes

Inventor： Pradeep Kumar ,  Rodney Agustinho Fernandes

IPC: C07D30930

CPC classification number: C07D309/30 ,  Y02P20/582

Abstract: The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hydride opening of the cyclic sulfite/sulfate as the key steps. The invention also resides in the intermediates used in the process.

Abstract translation: 本发明涉及一种用于合成（4R，6S）-4-羟基-6-羟甲基四氢吡喃-2-酮的改进的，有效的和对映体选择性方法，采用Sharpless不对称二羟基化和区域特异性亲核氢化物开环的环状 亚硫酸盐/硫酸盐为关键步骤。 本发明也在于该方法中使用的中间体。

公开(公告)号：US10992817B2

公开(公告)日：2021-04-27

申请号：US12406916

申请日：2009-03-18

Applicant: Pradeep Kumar ,  Mikel Robert Delagrange

Inventor： Pradeep Kumar ,  Mikel Robert Delagrange

IPC: H04M15/00 ,  G06Q30/06 ,  G06Q20/20 ,  G06Q30/02 ,  H04W4/24 ,  H04W12/06 ,  H04W8/24 ,  H04W4/14 ,  H04M17/00

Abstract: Methods, systems, and computer readable media for selecting and delivering an electronic value certificate to a mobile device are disclosed. According to one aspect, the method includes utilizing a certificate selection device to generate electronic certificate selection information and providing the electronic certificate selection information and associated recipient data to a merchant server. From the merchant server, electronic value certificate data derived from the certificate selection information is received. The method also includes establishing a communications link with a mobile device corresponding to the recipient data. The electronic value certificate data is provisioned on the mobile device over the communications link via over the air (OTA) communications.