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106 条记录 (耗时 0.036 秒)

    HEAT EXCHANGER
    31.
    发明申请
    HEAT EXCHANGER 有权
    热交换器

    公开(公告)号：US20080023189A1

    公开(公告)日：2008-01-31

    申请号：US11780218

    申请日：2007-07-19

    申请人： Naoki Kimura ,  Akira Hideno

    发明人： Naoki Kimura ,  Akira Hideno

    IPC分类号： F28F13/00

    CPC分类号： F28F3/02 ,  F28F3/022 ,  F28F13/02 ,  H01L23/467 ,  H01L23/473 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A heat exchanger including a base plate portion with at least one heat generating component thermally connected thereto; at least one fin portion comprising a plurality of fins thermally connected to said base plate portion, arranged in parallel at a prescribed angle along a longitudinal direction of said base plate portion; an inlet portion through which a cooling fluid is introduced to each of said at least one fin portion; a baffle plate portion and a partition plate portion guiding said cooling fluid so that the cooling fluid is decelerated to be uniformly flown through fins in said at least one fin portion; and an outlet portion to evacuate the cooling fluid.

    摘要翻译： 一种热交换器，包括具有与其热连接的至少一个发热部件的基板部分; 至少一个翅片部分，其包括热连接到所述基板部分的多个翅片，沿着所述基板部分的纵向方向以预定角度平行设置; 入口部分，冷却流体通过该入口部分引导到所述至少一个翅片部分中的每一个; 挡板部分和引导所述冷却流体的分隔板部分，使得冷却流体减速以均匀地流过所述至少一个翅片部分中的翅片; 以及排出冷却流体的出口部。

    Tip for biomolecular reaction
    32.
    发明申请
    Tip for biomolecular reaction 审中-公开
    生物分子反应的提示

    公开(公告)号：US20070202014A1

    公开(公告)日：2007-08-30

    申请号：US11592900

    申请日：2006-11-03

    申请人： Naoki Kimura

    发明人： Naoki Kimura

    IPC分类号： B01L3/02

    CPC分类号： G01N33/5302 ,  B01L3/0275 ,  B01L2200/0631 ,  B01L2300/0681

    摘要： A tip for biomolecular reaction comprises a dispensing tip and a support which is placed inside the dispensing tip and on which a biomolecule is immobilized is provided, and thereby biomolecular reaction and washing can be easily performed in a short period of time.

    摘要翻译： 用于生物分子反应的尖端包括分配尖端和放置在分配尖端内部并且其上固定有生物分子的支撑体，从而可以在短时间内容易地进行生物分子反应和洗涤。

    Method of detecting a nucleic acid using a fluorescent group-containing carbodiimide as a label
    34.
    发明授权
    Method of detecting a nucleic acid using a fluorescent group-containing carbodiimide as a label 失效
    使用含荧光基的碳二亚胺作为标记检测核酸的方法

    公开(公告)号：US07135293B2

    公开(公告)日：2006-11-14

    申请号：US10654305

    申请日：2003-09-02

    申请人： Naoki Kimura ,  Namiko Shiohata ,  Yoko Yoshikawa

    发明人： Naoki Kimura ,  Namiko Shiohata ,  Yoko Yoshikawa

    IPC分类号： C12Q1/68

    CPC分类号： C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1088 ,  Y10T436/143333

    摘要： A novel fluorescent group-containing carbodiimide compound having at least one group selected from a carboxyl group, a sulfo group, a phosphono group and a phospho group which have substitution of an alkali metal, an alkaline earth metal or a basic group containing a nitrogen or phosphorus atom, which is prepared by using a novel fluorescent group-containing carbodiimide compound precursor having a halogen atom or a sulfonic acid group; and a method for detecting a nucleic acid by hybridization utilizing a nucleic acid labeled with a labeling substance, which utilizes the fluorescent group-containing carbodiimide compound as the labeling substance.

    摘要翻译： 具有选自羧基，磺基，膦酰基和磷酸基中的至少一个基团的含荧光基团的碳二亚胺化合物，其具有碱金属，碱土金属或含氮的碱性基团的取代基，或 磷原子，其通过使用具有卤素原子或磺酸基的新的含有荧光团的碳二亚胺化合物前体制备; 以及利用利用含荧光基的碳二亚胺化合物作为标记物质的用标记物质标记的核酸杂交来检测核酸的方法。

    Solid-state image pickup device used as a photoelectric conversion device with improved dynamic range
    36.
    发明授权
    Solid-state image pickup device used as a photoelectric conversion device with improved dynamic range 失效
    固态摄像装置用作具有改善的动态范围的光电转换装置

    公开(公告)号：US07067785B2

    公开(公告)日：2006-06-27

    申请号：US10439066

    申请日：2003-05-15

    申请人： Naoki Kimura

    发明人： Naoki Kimura

    IPC分类号： H01L27/00 ,  G04N5/335

    CPC分类号： H04N5/374 ,  H04N5/365 ,  H04N5/3745

    摘要： It is an object of the present invention to provide a solid-state image pickup device capable of preventing any output variation due to a threshold voltage variation, and preventing a dynamic range from being narrowed in conjunction with deterioration in outputs due to a lowered threshold voltage. The present invention provides improvements in type and connection of a reset transistor, a select transistor, and an amplifier transistor to achieve the above object. Specifically, the present invention provides a solid-state image pickup device comprising a first MOS transistor serving as a reset switch, a second MOS transistor serving as a select switch, a photodiode, and a third MOS transistor having a source connected in series with the photodiode. In this solid-state image pickup device, the first and second MOS transistors are connected in series with one another between a voltage source and an output end, and the photodiode and the third MOS transistor are connected in series with one another between a voltage source and a ground. Further, the connection point between the first and second MOS transistors is connected to the gate of the third MOS transistor.

    摘要翻译： 本发明的目的是提供一种固态摄像装置，其能够防止由于阈值电压变化引起的任何输出变化，并且由于阈值电压降低而导致动态范围变窄与输出的劣化相结合 。 本发明提供了复位晶体管，选择晶体管和放大器晶体管的类型和连接的改进以实现上述目的。 具体地说，本发明提供一种固态摄像装置，其特征在于，包括：作为复位开关的第一MOS晶体管，用作选择开关的第二MOS晶体管，光电二极管，以及与源极连接的源极的第三MOS晶体管 光电二极管 在这种固体摄像装置中，第一和第二MOS晶体管在电压源和输出端之间彼此串联连接，并且光电二极管和第三MOS晶体管彼此串联连接在电压源 和地面。 此外，第一和第二MOS晶体管之间的连接点连接到第三MOS晶体管的栅极。

    Oligonucleotide-immobilized substrate for detecting methylation
    37.
    发明申请
    Oligonucleotide-immobilized substrate for detecting methylation 有权
    用于检测甲基化的寡核苷酸固定底物

    公开(公告)号：US20050089870A1

    公开(公告)日：2005-04-28

    申请号：US10677853

    申请日：2003-10-02

    申请人： Nagahide Matsubara ,  Takeshi Nagasaka ,  Naoki Kimura ,  Osamu Suzuki

    发明人： Nagahide Matsubara ,  Takeshi Nagasaka ,  Naoki Kimura ,  Osamu Suzuki

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6827 ,  C12Q2600/156 ,  C12Q2531/113 ,  C12Q2523/125 ,  C12Q2565/501

    摘要： The presence or absence of methylation of C's in CpG dinucleotide in a sample DNA that contains a target sequence including the CpG dinucleotide is detected as follows. Multiple kinds of capture oligonucleotides immobilized on a base material and including: an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which all of C's other than C's in the all of CpG dinucleotide are replaced with T's; and an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which all of C's are replaced with T's are hybridized with the sample DNA in which non-methylated C's have been converted into U's by deamination or an amplification product thereof, and the presence or absence of methylation is detected based on the result of the hybridization.

    摘要翻译： 在包含CpG二核苷酸的靶序列的样品DNA中CpG二核苷酸中C的甲基化的存在或不存在如下。 固定在基材上的多种捕获寡核苷酸，包括：与对应于靶序列的核苷酸序列互补或相同的核苷酸序列的寡核苷酸，其中所有CpG二核苷酸中除C以外的全部C被T ; 并且具有与对应于其中全部C被T替换的靶序列的核苷酸序列互补或相同的核苷酸序列的寡核苷酸与其中非甲基化C已经通过脱氨酸转化成U的样品DNA杂交或 其扩增产物，并且基于杂交的结果检测甲基化的存在或不存在。

    Fluorescent group-containing carbodiimide compound and process for producing the compound
    38.
    发明授权
    Fluorescent group-containing carbodiimide compound and process for producing the compound 失效
    含荧光体的碳二亚胺化合物及其制造方法

    公开(公告)号：US06825195B2

    公开(公告)日：2004-11-30

    申请号：US10154321

    申请日：2002-05-21

    申请人： Naoki Kimura

    发明人： Naoki Kimura

    IPC分类号： A61K315375

    CPC分类号： G01N33/533 ,  C07C267/00 ,  C09B23/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033

    摘要： A novel carbodiimide compound represented by the general formula (1) having an ester linkage and containing a fluorescent group can be prepared for providing a novel carbodiimide compound and a process for producing such a compound, in which the fluorescent group of such a compound can be efficiently introduced into a nucleic acid including a naturally-occurring nucleic acid or into a protein in a simple manner, while retaining a sufficient solubility to water. In addition, a fluorescent group-containing compound and a carbodiimide compound which can be efficiently coupled together in a simple manner.

    摘要翻译： 可以制备具有酯键并含有荧光基团的由通式（1）表示的新颖的碳二亚胺化合物，用于提供新的碳二亚胺化合物和这种化合物的制备方法，其中这种化合物的荧光基团可以是 在保持足够的水溶解性的同时，以简单的方式有效地引入包括天然存在的核酸的核酸或蛋白质中。 此外，可以简单地将荧光基团化合物和碳二亚胺化合物有效地耦合在一起。

    Secretory membrane protein that induces osteoblast differentiation
    39.
    发明授权
    Secretory membrane protein that induces osteoblast differentiation 失效
    诱导成骨细胞分化的分泌膜蛋白

    公开(公告)号：US06784284B2

    公开(公告)日：2004-08-31

    申请号：US09855266

    申请日：2001-05-14

    申请人： Naoki Kimura ,  Tomoko Toyoshima

    发明人： Naoki Kimura ,  Tomoko Toyoshima

    IPC分类号： C07K1400

    CPC分类号： G01F11/18 ,  C07K14/705 ,  C07K14/70575 ,  G01F11/40

    摘要： Three genes encoding secretory membrane proteins have been successfully isolated from an osteoblast-like cell line by a method for specifically cloning secretory membrane proteins. One of these genes encodes a novel receptor protein. The protein has only the extracellular region, binds to the cell membrane via a GPI anchor, and carries therein a cysteine-rich, repetitive region commonly conserved in the TNF receptor super family. Overexpression of this protein in osteoblast-like cell line cells suppresses cell proliferation, changes cell morphology, and increases alkaline phosphatase activity, which is one of markers for differentiation of osteoblasts.

    摘要翻译： 已经通过特异性克隆分泌膜蛋白的方法从成骨细胞样细胞系成功地分离了编码分泌膜蛋白的三个基因。 这些基因之一编码新的受体蛋白。 蛋白质仅具有细胞外区域，通过GPI锚定体与细胞膜结合，并携带其中通常在TNF受体超家族中保守的富含半胱氨酸的重复区域。 这种蛋白质在成骨细胞样细胞系细胞中的过表达抑制细胞增殖，改变细胞形态，并增加碱性磷酸酶活性，这是成骨细胞分化的标志物之一。