公开(公告)号：US20220379118A1

公开(公告)日：2022-12-01

申请号：US17882482

申请日：2022-08-05

Applicant: NeuroPace, Inc.

Inventor： Sharanya Arcot Desai ,  Thomas K. Tcheng

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

Abstract: Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.

公开(公告)号：US20200316383A1

公开(公告)日：2020-10-08

申请号：US16906914

申请日：2020-06-19

Applicant: NeuroPace, Inc.

Inventor： Sharanya Arcot Desai ,  Thomas K. Tcheng

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

Abstract: Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.

公开(公告)号：US10390721B2

公开(公告)日：2019-08-27

申请号：US15478168

申请日：2017-04-03

Applicant: NeuroPace, Inc.

Inventor： Thomas K. Tcheng

IPC: A61N1/05 ,  A61N1/36 ,  A61B5/0478 ,  A61B5/00 ,  A61B5/026 ,  A61B5/1455 ,  A61B5/16 ,  A61B5/0205 ,  A61B5/04 ,  A61N1/02

Abstract: A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

公开(公告)号：US08934980B2

公开(公告)日：2015-01-13

申请号：US13784569

申请日：2013-03-04

Applicant: NeuroPace, Inc.

Inventor： Benjamin D. Pless ,  Thomas K. Tcheng

IPC: A61N1/00 ,  A61N1/36 ,  A61M5/142 ,  A61N1/05

CPC classification number: A61N1/36135 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/076 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/743 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36078 ,  A61N1/36139

Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

Abstract translation: 适用于为各种神经障碍提供治疗的可植入神经刺激器系统能够基于要递送治疗的上下文（生理或其他）改变治疗递送策略。 根据各种传感器测量，计算，推断和设备状态（包括经过时间和时间），在这种情况下提供适当的治疗方案，响应和预定的治疗方法可以不同。