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    Medical device with porous surface for controlled drug release and method of making the same
    38.
    发明授权
    Medical device with porous surface for controlled drug release and method of making the same 失效
    具有多孔表面的医疗装置用于受控药物释放及其制备方法

    公开(公告)号：US06652581B1

    公开(公告)日：2003-11-25

    申请号：US09110697

    申请日：1998-07-07

    Applicant: Ni Ding

    Inventor： Ni Ding

    IPC: A61F206

    CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42

    Abstract: The medical devices of the invention have a portion with a porous surface for release of at least one biologically active agent therefrom. The porous surface is made of a material such as a polymer having a plurality of voids. To load the porous surface with a biologically active agent or drug, an electrophoresis method is employed. In this method, a device having a porous surface is placed into a drug solution or suspension, along with an electrode. An electric current is applied to the device and electrode. Under such a current, the drug, which has a positive or negative charge, will be loaded into the pores or voids of the porous surface.

    Abstract translation: 本发明的医疗装置具有用于从其释放至少一种生物活性剂的多孔表面的部分。 多孔表面由诸如具有多个空隙的聚合物的材料制成。 为了用生物活性剂或药物加载多孔表面，使用电泳方法。 在该方法中，具有多孔表面的装置与电极一起放入药液或悬浮液中。 电流被施加到器件和电极上。 在这样的电流下，具有正电荷或负电荷的药物将被加载到多孔表面的孔或空隙中。

    Drug-releasing coatings for medical devices
    40.
    发明授权
    Drug-releasing coatings for medical devices 失效
    用于医疗器械的药物释放涂层

    公开(公告)号：US06316018B1

    公开(公告)日：2001-11-13

    申请号：US09491152

    申请日：2000-01-26

    Applicant: Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    Inventor： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC: A61F202

    CPC classification number: A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    Abstract: The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.

    Abstract translation: 本发明涉及具有药物释放涂层的医疗装置及其制造方法。 涂层允许通过储存器概念在医疗装置的表面上定时或延长药理活性。 具体地说，该涂层包括至少两层：包含至少一种药物 - 离子表面活性剂复合物的外层，其中包含聚合物的储存层和基本上不含离子表面活性剂的药物。 在暴露于用这种涂层覆盖的医疗装置的身体组织上时，外层中的离子结合药物被释放到体液或组织中。 释放这种结合药物后，外层中的离子表面活性剂结合位点留空。 为了在输送离子结合的药物之后保持药理活性，将额外量的药物以允许基本上不含离子表面活性剂的药物与储存层中的空位结合位点复合的方式嵌入或并入储存层中 外层的离子表面活性剂。 结果，医疗装置的表面富含药物以提供持续的药理活性，以防止由于存在医疗装置而引起的不良反应。 本发明进一步涉及具有稳定的药物释放涂层的医疗装置。 通过暴露于低能量，相对非穿透能量源（例如气体等离子体或电子束能量源）来使涂层稳定。

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