利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

99 条记录 (耗时 0.042 秒)

    Compositions and their uses directed to PTPRU
    37.
    发明授权
    Compositions and their uses directed to PTPRU 有权
    组合及其针对PTPRU的用途

    公开(公告)号：US08202981B2

    公开(公告)日：2012-06-19

    申请号：US13009626

    申请日：2011-01-19

    申请人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    发明人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。

    Compositions and their uses directed to hepcidin
    39.
    发明授权
    Compositions and their uses directed to hepcidin 失效
    组合物及其用于铁调素的用途

    公开(公告)号：US08076306B2

    公开(公告)日：2011-12-13

    申请号：US11734562

    申请日：2007-04-12

    申请人： Brett P. Monia ,  C. Frank Bennett ,  William A. Gaarde ,  Trisha Lockhart ,  Robert McKay

    发明人： Brett P. Monia ,  C. Frank Bennett ,  William A. Gaarde ,  Trisha Lockhart ,  Robert McKay

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12N5/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for increasing red blood cell count in an animal. Also provided are methods for the prevention, amelioration and/or treatment of low serum iron levels, low red blood cell count and other clinical endpoints of anemia in an animal. These methods may be achieved by administration of compounds or compositions including antisense compounds targeted to a nucleic acid that expresses hepcidin polypeptide combined with an erythropoiesis stimulating agent.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中铁调素表达或预防，改善或治疗贫血的化合物，组合物和方法。 还提供了用于预防，改善或治疗贫血以及用于增加动物中红细胞计数的方法。 还提供了用于预防，改善和/或治疗动物体内低血清铁水平，低红细胞计数和贫血的其它临床终点的方法。 这些方法可以通过施用化合物或组合物来实现，所述化合物或组合物包括靶向表达与促红细胞生成刺激剂组合的铁调素多肽的核酸的反义化合物。

    COMPOSITIONS AND THEIR USES DIRECTED TO PTPRU
    40.
    发明申请
    COMPOSITIONS AND THEIR USES DIRECTED TO PTPRU 有权
    组合物及其用于PTPRU的用途

    公开(公告)号：US20110112171A1

    公开(公告)日：2011-05-12

    申请号：US13009626

    申请日：2011-01-19

    申请人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    发明人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    IPC分类号： A61K31/7088 ,  A61P3/10 ,  A61P3/06 ,  A61P3/04 ,  A61P9/00

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart diseaseby administration of antisense compounds targeted to PTPRU.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予靶向PTPRU的反义化合物的冠心病。