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    IMAGE ANALYIS METHOD AND SYSTEM
    31.
    发明申请
    IMAGE ANALYIS METHOD AND SYSTEM 失效
    图像分析方法与系统

    公开(公告)号：US20120045106A1

    公开(公告)日：2012-02-23

    申请号：US13265547

    申请日：2010-05-12

    申请人： Pasha Razifar ,  Bengt Langstrom

    发明人： Pasha Razifar ,  Bengt Langstrom

    IPC分类号： G06K9/00

    CPC分类号： A61B6/037 ,  A61B6/03 ,  G06T5/003 ,  G06T2207/10084 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/30016

    摘要： The invention relates to a system and method for enhancing image data obtained from a positron emission tomography (PET) scan. In various embodiments, the method comprises transforming an original image data set to provide a first modified image data set by performing a masked volume-wise principal component analysis (MVW-PCA) on the original image data set. The first modified image data set is then transformed to provide a second modified image data set by performing a masked volume-wise independent component analysis (MVW-ICA) on the first modified image data set, the second modified image data set thereby comprising enhanced image data.

    摘要翻译： 本发明涉及一种用于增强从正电子发射断层摄影（PET）扫描获得的图像数据的系统和方法。 在各种实施例中，该方法包括通过在原始图像数据集上执行屏蔽的体积主成分分析（MVW-PCA）来变换原始图像数据集以提供第一修改图像数据集。 然后，对第一修改图像数据集进行变换以提供第二修改图像数据集，通过对第一修改图像数据集执行掩蔽的体积独立分量分析（MVW-ICA），由此包括增强图像 数据。

    18F-Labeled Phenoxyphenyl Nu-benzyl Alkanamid Derivatives for Positron Emission Tomography (PET) Imaging of Peripheral Benzodiazepine Receptor
    34.
    发明申请
    18F-Labeled Phenoxyphenyl Nu-benzyl Alkanamid Derivatives for Positron Emission Tomography (PET) Imaging of Peripheral Benzodiazepine Receptor 审中-公开
    18F标记的苯氧基苯基Nu-苄基胺酰胺衍生物用于正电子发射断层扫描（PET）成像外周苯并二氮杂受体

    公开(公告)号：US20090142264A1

    公开(公告)日：2009-06-04

    申请号：US12159016

    申请日：2006-12-27

    申请人： Bengt Langstrom ,  Farhad Karimi

    发明人： Bengt Langstrom ,  Farhad Karimi

    IPC分类号： A61K51/04 ,  C07C233/00

    CPC分类号： C07B59/001

    摘要： The present invention provides novel 18F-labeled phenoxyphenyl N-benzyl alkanamid derivative compounds that are suitable for use as an in vivo imaging agent. A pharmaceutical comprising the compound and a kit for the preparation of the pharmaceutical are also provided. Methods of use and use of claims for novel 18F-labeled phenoxyphenyl N-benzyl alkanamid derivative compounds are provided as well.

    摘要翻译： 本发明提供了适合用作体内成像剂的新颖的18F标记的苯氧基苯基N-苄基烷酰胺衍生物。 还提供了包含该化合物的药物和用于制备药物的试剂盒。 也提供了新的18F标记的苯氧基苯基N-苄基烷酰胺衍生物化合物的权利要求书的使用和使用方法。

    Positron emitter labeled enzyme inhibitors
    35.
    发明授权
    Positron emitter labeled enzyme inhibitors 失效
    正电子发射体标记的酶抑制剂

    公开(公告)号：US4913891A

    公开(公告)日：1990-04-03

    申请号：US52921

    申请日：1987-05-22

    申请人： Joanna S. Fowler ,  Robert R. MacGregor ,  Alfred P. Wolf ,  Bengt Langstrom

    发明人： Joanna S. Fowler ,  Robert R. MacGregor ,  Alfred P. Wolf ,  Bengt Langstrom

    IPC分类号： A61K51/04

    CPC分类号： A61K51/0406 ,  A61K2123/00

    摘要： This invention involves a new strategy for imaging and mapping enzyme activity in the living human and animal body using positron emitter-labeled suicide enzyme inactivators or inhibitors which become covalently bound to the enzyme as a result of enzymatic catalysis. Two such suicide inactivators for monoamine oxidase have been labeled with carbon-11 and used to map the enzyme subtypes in the living human and animal body using PET. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography.

    摘要翻译： 本发明涉及使用正电子发射体标记的自杀酶灭活剂或由于酶促催化而与酶共价结合的抑制剂在活的人和动物体中成像和测定酶活性的新策略。 已经用碳-11标记了两种用于单胺氧化酶的这种自杀灭活剂，并且用于使用PET对活的人和动物体中的酶亚型进行映射。 通过使用正电子发射断层扫描来对由碳-11发射的身体穿透辐射产生的放射性分布进行成像，获得功能活性单胺氧化酶活性的图谱。 Clorgyline和L-去肾上腺素是自杀性酶抑制剂，并且不可逆地抑制单胺氧化酶。 当这些抑制剂用碳-11标记时，它们使用正电子发射断层扫描为体内单胺氧化酶定位和反应性提供选择性探针。

    Purification of 68Ge/68Ga generator eluate from Fe(III) intended to improve specific radioactivity of 68Ga-based radiopharmaceuticals
    36.
    发明授权
    Purification of 68Ge/68Ga generator eluate from Fe(III) intended to improve specific radioactivity of 68Ga-based radiopharmaceuticals 有权
    从Fe（III）中纯化68Ge / 68Ga发生器洗脱液，旨在提高68Ga类放射性药物的比放射性

    公开(公告)号：US09487410B2

    公开(公告)日：2016-11-08

    申请号：US12745715

    申请日：2008-12-01

    申请人： Bengt Langstrom ,  Irina Velikyan

    发明人： Bengt Langstrom ,  Irina Velikyan

    IPC分类号： C01G15/00

    CPC分类号： C01G15/003 ,  A61K51/02 ,  B01J41/04 ,  C01P2006/80 ,  C01P2006/88

    摘要： The present invention provides a method of purifying 68Ge/68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invention further depicts the use of an automated system for the production of 68Ga-radiolabelled PET tracers with high specific radioactivity and a kit for purifying 68Ge/68Ga generator produced 68Ga from Fe (III).

    摘要翻译： 本发明提供了一种从Fe（III）中纯化68Ge / 68Ga发生器68Ga的纯化方法。 本发明还涉及现有的Gallea Synthia原型中的自动化系统，其提供来自各种阳离子的纯度68Ga和68Ga的预浓缩。 通常，本发明还描述了使用自动化系统来生产具有高比放射性的68Ga放射性标记的PET示踪剂和用于纯化从Fe（III）制备的68Ga的68Ge / 68Ga发生器的试剂盒。

    Method and system of multivariate analysis on volume-wise data of reference structure normalized images for improved quality in positron emission tomography studies
    38.
    发明授权
    Method and system of multivariate analysis on volume-wise data of reference structure normalized images for improved quality in positron emission tomography studies 失效
    参考结构体积数据多元分析方法和系统，正电子发射断层扫描研究提高质量标准化图像

    公开(公告)号：US08233689B2

    公开(公告)日：2012-07-31

    申请号：US12065119

    申请日：2006-08-31

    申请人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    发明人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    IPC分类号： G06K9/00

    CPC分类号： G01N23/00 ,  G06T5/002 ,  G06T5/008 ,  G06T7/0012 ,  G06T2207/10104 ,  G06T2207/30016

    摘要： A method and system are provided to mask out the background in dynamic PET images, to perform pre-normalization on the masked dynamic PET images, and to apply multivariate image analysis (e.g., principal component analysis PCA) on the masked pre-normalized dynamic PET images in order to improve the quality of the dynamic PET images and the PET study. A masking operation applies PCA to untreated dynamic PEET images before any pre-normalization in order to mask out the background pixels. This masking operation uses the Otsu method. A first normalization method is background noise pre-normalization where pixel values are corrected for background noise. A second normalization method is kinetic pre-normalization where the contrast within an image is improved. Multivariate analysis such as PCA may be applied on the whole volume to find the largest variance in the structure.

    摘要翻译： 提供了一种方法和系统来掩盖动态PET图像中的背景，对掩蔽的动态PET图像执行预归一化，并将多变量图像分析（例如主成分分析PCA）应用于掩蔽的预标准化动态PET 图像以提高动态PET图像和PET研究的质量。 屏蔽操作在任何预归一化之前将PCA应用于未处理的动态PEET图像，以便屏蔽背景像素。 该掩蔽操作使用Otsu方法。 第一归一化方法是对背景噪声校正像素值的背景噪声预归一化。 第二种归一化方法是动态预归一化，其中图像内的对比度得到改善。 多变量分析如PCA可以应用在整个体积上，以找出结构中最大的变化。

    Method and System of Multivariate Analysis on Normalized Volume-Wise Data in the Sinogram Domain For Improved Quality in Positron Emission Tomography Studies
    39.
    发明申请
    Method and System of Multivariate Analysis on Normalized Volume-Wise Data in the Sinogram Domain For Improved Quality in Positron Emission Tomography Studies 失效
    方法与系统的多因素分析正常化体积数据在Sinogram领域提高质量正电子发射断层扫描研究

    公开(公告)号：US20080310697A1

    公开(公告)日：2008-12-18

    申请号：US12065140

    申请日：2006-08-31

    申请人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    发明人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    IPC分类号： G06K9/00

    CPC分类号： G06T11/005 ,  G06T5/002 ,  G06T5/10 ,  G06T2207/10088 ,  G06T2207/20132 ,  G06T2211/412

    摘要： A method and system are provided for improving the quality in positron emission tomography (PET) images. PET input data is masked using raw dynamic PET data (sinograms) as input for primary component analysis (PCA) that generates primary components which in turn are used to create a mask. This mask can be used to allow object pixel data to be extracted from the sinograms into masked sinograms where background pixels outside the reference object are set to zero. A volume-wise approach to PCA uses masked sinograms as input data. Pixel-wise noise pre-normalization may then be performed generating pre-normalized sinograms from the masked PET input data. PCA is then performed on the pre-normalized sinograms resulting in PCA sinograms recreated into PCA-modified sinograms by adding background pixel values of zero. These PCA-modified sinograms may optionally be scaled and may then be reconstructed into dynamic PET images with improved image quality.

    摘要翻译： 提供了一种提高正电子发射断层摄影（PET）图像质量的方法和系统。 PET输入数据使用原始动态PET数据（正弦图）作为主要成分分析（PCA）的输入进行掩蔽，主成分分析（PCA）产生主要成分，而主成分又用于创建掩模。 该掩模可以用于允许将对象像素数据从正弦图提取到被引用对象外部的背景像素设置为零的掩蔽的正弦图。 PCA使用屏蔽的正弦图作为输入数据。 然后可以从掩蔽的PET输入数据生成预标准化的正弦图像素像噪声预归一化。 然后在预标准化的正弦图上进行PCA，通过添加零的背景像素值，将PCA正弦图重新创建成PCA修正的正弦图。 这些PCA修改的正弦图可以可选地被缩放，然后可以被重建成具有改善的图像质量的动态PET图像。