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    Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent
    31.
    发明授权
    Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent 有权
    Overhauser磁共振成像（ORMI）方法包括磁共振（MR）成像剂的离体极化

    公开(公告)号：US06311086B1

    公开(公告)日：2001-10-30

    申请号：US09460094

    申请日：1999-12-13

    申请人： Jan Henrik Ardenkjaer-Larsen ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Oskar Axelsson

    发明人： Jan Henrik Ardenkjaer-Larsen ,  Klaes Golman ,  Georg Hansson ,  Ib Leunbach ,  Stefan Petersson ,  Lars-Goran Wistrand ,  Oskar Axelsson

    IPC分类号： A61B505

    CPC分类号： A61K49/10 ,  A61K49/08 ,  A61K49/18 ,  A61K49/20 ,  G01R33/5601 ,  G01R33/62

    摘要： This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.

    摘要翻译： 本发明提供了一种样品的MR研究方法，该方法包括：（i）在均匀的磁场中放置包含OMRI造影剂和含有能够发射磁共振信号的核（MR成像核）的MR成像剂的组合物 （例如初级磁场B0），并且能够表现出6秒以上的T1弛豫时间（在7T的场中在D2O中为37℃）; （ii）将组合物暴露于在OMRI造影剂中激发电子自旋跃迁的频率的第一辐射; （iii）任选地但优选地将所述OMRI造影剂的全部，基本上全部或一部分与所述MR成像剂分离; （iv）向所述样品施用所述MR成像剂，（v）将所述样品暴露于选定为激发核自旋转变的频率的第二辐射; （vi）检测来自样品的磁共振信号; 和（vii）可选地，从检测到的信号生成图像或动态流量数据。

    Synthesis of cyclen derivatives
    36.
    发明申请
    Synthesis of cyclen derivatives 失效
    环烯衍生物的合成

    公开(公告)号：US20090216011A1

    公开(公告)日：2009-08-27

    申请号：US11911848

    申请日：2006-04-18

    申请人： Oskar Axelsson ,  Andreas Olsson

    发明人： Oskar Axelsson ,  Andreas Olsson

    IPC分类号： C07D257/02

    CPC分类号： C07D257/02

    摘要： The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity.

    摘要翻译： 本发明涉及一种制备受保护的DO 3 A的改进方法，例如DO 3 A-三叔丁酯（1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸三叔丁酯）。 该化合物以盐形式制备。 该方法包括后处理程序，得到DO3A-三叔丁酯作为纯度优异的盐。

    CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICIAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS
    37.
    发明申请
    CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICIAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS 审中-公开
    具有3至4个参考火焰侧链的3至4个标识单体的环状共轭成像和光谱法的对比剂

    公开(公告)号：US20090110640A1

    公开(公告)日：2009-04-30

    申请号：US12294263

    申请日：2006-12-01

    申请人： Oskar Axelsson ,  Alan Cuthbertson ,  Andreas Meijer

    发明人： Oskar Axelsson ,  Alan Cuthbertson ,  Andreas Meijer

    IPC分类号： A61K49/06 ,  C08G69/02 ,  A61K49/00

    CPC分类号： C07D487/22 ,  C07D471/22 ,  C07D498/22

    摘要： The present invention relates to: Compounds of formula (I) consisting of a cyclic polymer core A and groups -L-X attached to said core A-(L-X)n (I) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a chelator; and n denotes an integer of 3 or 4; Compound of formula (II) consisting of a cyclic polymer core A and groups -L-X′ attached to said core A-(L-X′)n (H) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a paramagnetic chelate consisting of a chelator X and a paramagnetic metal ion M; and n denotes an integer of 3 or 4; And compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and magnetic resonance spectroscopy (MRS).

    摘要翻译： 本发明涉及：由环状聚合物芯A和与所述核A-（LX）n（I）连接的基团-LX组成的式（I）化合物，其中A表示由3或4个相同的环状聚合物组成的环状聚合物 通过酰胺键连接的单体; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示螯合剂; n表示3或4的整数; 式（II）的化合物由环状聚合物核心A和与所述核 - （L-X'）n（H）连接的基团-LX'组成，其中A表示由3或4个相同的单体组成的环状聚合物， 通过酰胺键连接; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示由螯合剂X和顺磁性金属离子M组成的顺磁性螯合物; n表示3或4的整数; 以及包含式（II）化合物及其作为磁共振（MR）成像（MRI）和磁共振光谱学（MRS）中的造影剂的用途的组合物。

    Process for preparation of MR contrast agents
    38.
    发明授权
    Process for preparation of MR contrast agents 有权
    制备MR造影剂的方法

    公开(公告)号：US07459144B2

    公开(公告)日：2008-12-02

    申请号：US11002864

    申请日：2004-12-02

    申请人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    发明人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    IPC分类号： A61B5/055 ,  B01J10/00

    CPC分类号： A61K49/1815

    摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    摘要翻译： 本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢（p-1H 2）和/或邻 - 氘（o-2H 2）的氢气（H 2）的室中，从而氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

    Method of magnetic resonance investigation of a sample using a nuclear spin polarised MR imaging agent
    39.
    发明授权
    Method of magnetic resonance investigation of a sample using a nuclear spin polarised MR imaging agent 有权
    使用核自旋极化MR成像剂的样品的磁共振研究方法

    公开(公告)号：US07346384B2

    公开(公告)日：2008-03-18

    申请号：US10385822

    申请日：2003-03-11

    申请人： Stefan Petersson ,  Oskar Axelsson ,  Haukur Johanneson

    发明人： Stefan Petersson ,  Oskar Axelsson ,  Haukur Johanneson

    IPC分类号： A61B5/05

    CPC分类号： A61K49/08 ,  G01R33/5601

    摘要： The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations of the vasculature, b) exposing said sample or part of the sample to radiation of a frequency selected to excite nuclear spin transitions in said non-zero nuclear spin nuclei, c) detecting MR signals from said sample using any suitable manipulation method including pulse sequences. The invention also provides novel compounds.

    摘要翻译： 本发明提供了一种样品的对比增强磁共振成像方法，所述方法包括：a）向所述样品施用包含非零核自旋核的超极化MR造影剂，用于脉管系统的流体动力学研究，b）将所述 样品或样品的一部分以选定以激发所述非零核自旋核中的核自旋跃迁的频率的辐射，c）使用包括脉冲序列的任何合适的操作方法来检测来自所述样品的MR信号。 本发明还提供新的化合物。