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公开(公告)号：US07354739B2
公开(公告)日：2008-04-08
申请号：US10607706
申请日：2003-06-27
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
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32.发明授权Polynucleotide encoding adipocyte complement related protein homolog zacrp2 失效多核苷酸编码脂肪细胞补体相关蛋白同源物zacrp2公开(公告)号：US06921649B2
公开(公告)日：2005-07-26
申请号：US10621787
申请日：2003-07-17
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C12P21/02 , C12N1/00 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
摘要翻译： 本发明涉及用于zacrp2的多核苷酸和多肽分子，其是具有胶原样结构域和C1q结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp2多肽的抗体。
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公开(公告)号：US06890903B2
公开(公告)日：2005-05-10
申请号：US10268180
申请日：2002-10-09
申请人： Paul D. Bishop , Angelika Grossmann
发明人： Paul D. Bishop , Angelika Grossmann
CPC分类号： A61K38/45 , A61K38/4833 , A61K2300/00
摘要： Use of factor XIII for inhibiting the formation of seromas by administering factor XIII. The factor XIII can be administered locally at the site of a wound or surgery or administered systemically. If the factor XIII is administered locally, it can be activated or non-activated and may be administered in conjunction with activated thrombin.
摘要翻译： 使用因子XIII通过施用因子XIII抑制血清型的形成。 因子XIII可以在伤口或手术部位局部施用或全身给药。 如果因子XIII局部施用，则其可以被活化或未激活，并且可以与活化凝血酶联合施用。
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公开(公告)号：US06838438B2
公开(公告)日：2005-01-04
申请号：US09794987
申请日：2001-02-27
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/00 , C07K14/575 , A61K38/10 , C07K7/08 , C07K14/63
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US5710174A
公开(公告)日：1998-01-20
申请号：US483213
申请日：1995-06-07
申请人： Robert R. West , Teresa Martinez , Hank R. Franklin , Paul D. Bishop , Birgitte R.o slashed.mer Rassing
发明人： Robert R. West , Teresa Martinez , Hank R. Franklin , Paul D. Bishop , Birgitte R.o slashed.mer Rassing
IPC分类号： A61K31/365 , A61K38/48 , A61K38/49 , C07D313/00 , C12P17/12 , A61K31/335
CPC分类号： C12P17/12 , A61K31/365 , A61K38/484 , A61K38/49 , C07D313/00
摘要： A compound that is useful for inhibiting FXIIIa catalysis of fibrin cross-linking, and related pharmaceutical compositions and methods, are disclosed. The compound and compositions may be advantageously used to enhance fibrinolysis and resolution of blood clots.
摘要翻译： 公开了可用于抑制纤维蛋白交联的FXIIIa催化的化合物，以及相关的药物组合物和方法。 该化合物和组合物可有利地用于增强血栓的纤维蛋白溶解和分解。
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公开(公告)号：US5693098A
公开(公告)日：1997-12-02
申请号：US744400
申请日：1996-11-07
申请人： Fraser D. Rubens , Paul D. Bishop
发明人： Fraser D. Rubens , Paul D. Bishop
IPC分类号： A61L27/34 , A61L33/12 , A61F2/02 , A61K37/547
CPC分类号： A61L33/126 , A61L27/34 , Y10S623/92 , Y10S623/921 , Y10S623/922
摘要： Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
摘要翻译： 公开了用抗血栓形成或抗凝血剂蛋白质涂覆假体表面的方法。 所述方法包括使假体材料的表面与含有多聚纤维素降解产物的组合物接触。 这些多聚体，优选D-二聚体，具有交联的D结构域。 本发明的方法可用于在植入后暴露于患者血液的假体植入物例如血管移植物和人造心脏瓣膜上提供抗血栓形成性涂层。
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37.发明授权
公开(公告)号：US5609631A
公开(公告)日：1997-03-11
申请号：US430792
申请日：1995-04-28
申请人： Fraser D. Rubens , Paul D. Bishop
发明人： Fraser D. Rubens , Paul D. Bishop
IPC分类号： A61L27/34 , A61L33/12 , A61F2/02 , A61K37/547
CPC分类号： A61L33/126 , A61L27/34 , Y10S623/92 , Y10S623/921 , Y10S623/922
摘要： Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
摘要翻译： 公开了用抗血栓形成或抗凝血剂蛋白质涂覆假体表面的方法。 所述方法包括使假体材料的表面与含有多聚纤维素降解产物的组合物接触。 这些多聚体，优选D-二聚体，具有交联的D结构域。 本发明的方法可用于在植入后暴露于患者血液的假体植入物例如血管移植物和人造心脏瓣膜上提供抗血栓形成性涂层。
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公开(公告)号：US5324647A
公开(公告)日：1994-06-28
申请号：US121327
申请日：1993-09-14
申请人： Fraser D. Rubens , Paul D. Bishop
发明人： Fraser D. Rubens , Paul D. Bishop
CPC分类号： A61L33/126 , A61L27/34 , Y10T436/10
摘要： Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
摘要翻译： 聚合材料的表面涂有一层热变性纤维蛋白原。 纤维蛋白原可用凝血酶处理以产生纤维蛋白，并加入额外的纤维蛋白原和因子XIII以产生交联的纤维蛋白涂层。 所得涂层表面是稳定的，抗血栓形成的并且抗血小板粘附。 以这种方式涂覆的聚合材料可用于构建血管移植物和假体装置，并提供可用于研究血栓形成的测试系统。
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公开(公告)号：US10184701B2
公开(公告)日：2019-01-22
申请号：US14345034
申请日：2012-05-08
申请人： Lin Sun , Paul D. Bishop , Huai Yu Lin , Jose Alvares , Ramesh Veerasurla
发明人： Lin Sun , Paul D. Bishop , Huai Yu Lin , Jose Alvares , Ramesh Veerasurla
摘要： The disclosed refrigerant system includes a compressor having a motor that is cooled by motor cooling fluid provided to the motor from the main refrigerant loop by a motor cooling circuit. The system also includes a sub-cooling circuit to cool the motor cooling fluid.
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公开(公告)号：US20090264347A1
公开(公告)日：2009-10-22
申请号：US12495313
申请日：2009-06-30
申请人： Jan Ohrstrom , Paul D. Bishop , Lynn Massman Rose
发明人： Jan Ohrstrom , Paul D. Bishop , Lynn Massman Rose
CPC分类号： A61K38/45 , A61K38/095 , A61K38/37 , A61K2300/00
摘要： A patient having hemophilia A is treated by administering factor XIII generally in conjunction with factor VIII or desmopressin.
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