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公开(公告)号：US08163474B2
公开(公告)日：2012-04-24
申请号：US12405150
申请日：2009-03-16
申请人： Peter S. Lu , Michael P. Belmares , Carol Tan , Linda McAllister
发明人： Peter S. Lu , Michael P. Belmares , Carol Tan , Linda McAllister
IPC分类号： C12Q1/70 , G01N33/53 , A61K39/1451
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/11
摘要： The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type).
摘要翻译： 本申请描述了用于评估流感感染的方法，包括预后。 与单独的抗原相比，确定流感病毒的NS1和NP蛋白的量的测定显示增强的灵敏度和可靠性。 许多形式使用泛特异性抗体（即，与全部或至少与流感类型内的多种菌株反应）。
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公开(公告)号：US20090062213A1
公开(公告)日：2009-03-05
申请号：US12167852
申请日：2008-07-03
CPC分类号： G01N33/6896 , A61K38/06 , C12Q1/26 , G01N33/88 , G01N2500/00
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
摘要翻译： 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。
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公开(公告)号：US20090036376A1
公开(公告)日：2009-02-05
申请号：US12165983
申请日：2008-07-01
申请人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
发明人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
摘要翻译： 本发明提供了治疗或预防患有或有发生焦虑症状的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。
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公开(公告)号：US09629892B2
公开(公告)日：2017-04-25
申请号：US13816663
申请日：2011-08-12
IPC分类号： A61K38/07 , A61K38/08 , C07K7/06 , A61K47/48 , G01N33/573 , G01N33/68 , C12N9/02 , A61K38/17
CPC分类号： A61K38/07 , A61K38/08 , A61K38/1709 , A61K38/1787 , A61K47/645 , C07K7/06 , C07K2319/10 , C12N9/0075 , C12Y114/13039 , G01N33/573 , G01N33/6872 , G01N2333/70571 , G01N2333/90254 , G01N2500/02
摘要： The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).
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公开(公告)号：US20130267470A1
公开(公告)日：2013-10-10
申请号：US13816663
申请日：2011-08-12
IPC分类号： A61K38/07
CPC分类号： A61K38/07 , A61K38/08 , A61K38/1709 , A61K38/1787 , A61K47/645 , C07K7/06 , C07K2319/10 , C12N9/0075 , C12Y114/13039 , G01N33/573 , G01N33/6872 , G01N2333/70571 , G01N2333/90254 , G01N2500/02
摘要： The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).
摘要翻译： 本发明提供了治疗或预防对大脑或中枢神经系统其他部分的穿透性损伤的损伤作用的方法。 该方法部分基于穿透性弹道损伤啮齿动物模型的结果，表明PDF-95 NMDAR相互作用的抑制剂有效抑制由此类损伤引起的神经功能缺损。 这些方法对于治疗具有或具有渗透性脑损伤风险的受试者是有用的，包括头部受到攻击或有受伤风险的受试者（例如军事或执法人员）。
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公开(公告)号：US08633160B2
公开(公告)日：2014-01-21
申请号：US12167852
申请日：2008-07-03
CPC分类号： G01N33/6896 , A61K38/06 , C12Q1/26 , G01N33/88 , G01N2500/00
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
摘要翻译： 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。
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公开(公告)号：US08008253B2
公开(公告)日：2011-08-30
申请号：US12165983
申请日：2008-07-01
申请人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
发明人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
IPC分类号： A61K38/04
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
摘要翻译： 本发明提供了治疗或预防患有或有发生焦虑症状的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。
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公开(公告)号：US07595152B2
公开(公告)日：2009-09-29
申请号：US11698798
申请日：2007-01-26
申请人： Peter S. Lu , Michael P. Belmares , Dave Garman
发明人： Peter S. Lu , Michael P. Belmares , Dave Garman
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/542 , G01N33/00 , C12M1/34
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2500/02 , Y02A50/53 , Y02A50/60
摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.
摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。
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公开(公告)号：US20080227684A1
公开(公告)日：2008-09-18
申请号：US11618092
申请日：2006-12-29
IPC分类号： A61K31/404 , A61K31/195 , A61P25/00 , A61K31/519 , C07K2/00 , C07D209/10 , C07C311/46 , C07D491/147 , A61K38/00
CPC分类号： A61K31/195 , A61K31/404 , A61K31/519 , C07C229/58 , C07C233/54 , C07C233/56 , C07C237/42 , C07C311/21 , C07D209/10 , C07D491/147 , C07K5/0202
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
摘要翻译： 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。
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公开(公告)号：US07514224B2
公开(公告)日：2009-04-07
申请号：US11131042
申请日：2005-05-16
CPC分类号： G01N33/566 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , B01J2219/00659 , B01J2219/00725 , C07K14/705 , C07K2319/00 , C12N2310/315 , C40B40/10 , Y02A90/26 , Y10S436/809
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.
摘要翻译： 本发明提供了用于抑制或增强造血细胞中的蛋白质与涉及免疫应答中介的其它细胞之间的相互作用的试剂和方法。 提供的试剂和方法可用于治疗由免疫系统细胞介导的多种疾病和病症。
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