-
公开(公告)号:US07329661B2
公开(公告)日:2008-02-12
申请号:US11828367
申请日:2007-07-26
申请人: Hans Michael Buerger , Giorgio Caravatti , Juerg Zimmerman , Paul William Manley , Werner Breitenstein , Margaret Amelia Cudd
发明人: Hans Michael Buerger , Giorgio Caravatti , Juerg Zimmerman , Paul William Manley , Werner Breitenstein , Margaret Amelia Cudd
IPC分类号: A61K31/506 , C07D403/10
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式I的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书所述定义,其制备方法,包括那些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
-
公开(公告)号:US07244729B2
公开(公告)日:2007-07-17
申请号:US10485747
申请日:2002-08-06
IPC分类号: C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5355 , A61P35/00
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物
-
公开(公告)号:US20070161632A1
公开(公告)日:2007-07-12
申请号:US11686023
申请日:2007-03-14
IPC分类号: A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。
-
公开(公告)号:US20080096883A1
公开(公告)日:2008-04-24
申请号:US11573235
申请日:2005-08-10
申请人: Giorgio Caravatti , Pascal Furet , Patricia Imbach , Georg Martiny-Baron , Lawrence Blas Perez , Tao Sheng
发明人: Giorgio Caravatti , Pascal Furet , Patricia Imbach , Georg Martiny-Baron , Lawrence Blas Perez , Tao Sheng
IPC分类号: A61K31/5375 , A61K31/426 , A61K31/47 , A61K31/497 , C07D217/00 , C07D239/72 , C07D403/00 , C07D413/02 , C07D277/62 , C07D237/30 , A61P43/00 , A61K31/50 , A61K31/517
CPC分类号: C07D277/62 , C07D217/02 , C07D237/30 , C07D239/74 , C07D239/84
摘要: The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.
摘要翻译: 本发明涉及式(I)的三氟甲基取代的苯甲酰胺化合物,包含这些化合物的药物,它们作为或用于制造药物的用途,特别是作为蛋白激酶的抑制剂和/或病症,病症或疾病状态介导的治疗 通过蛋白激酶活性和/或增殖性疾病,治疗方法包括施用化合物,特别是治疗和预防治疗的化合物和新中间体的制备方法及其合成的部分步骤。
-
公开(公告)号:US07390805B2
公开(公告)日:2008-06-24
申请号:US11686023
申请日:2007-03-14
IPC分类号: C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/497 , A06P35/04
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。
-
公开(公告)号:US06387927B1
公开(公告)日:2002-05-14
申请号:US09871860
申请日:2001-06-01
IPC分类号: A61K31428
CPC分类号: C07D405/04 , C07D413/04 , C07D417/04 , C07D493/04
摘要: The invention relates to anti-tumour-effective compounds of formula (I), wherein the radicals have the meanings given in the description.
摘要翻译: 本发明涉及抗肿瘤有效的式(I)化合物,其中基团具有在说明书中给出的含义。
-
公开(公告)号:US20060223818A1
公开(公告)日:2006-10-05
申请号:US11448649
申请日:2006-06-07
申请人: Hans Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul Manley , Werner Breitenstein , Margaret Cudd
发明人: Hans Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul Manley , Werner Breitenstein , Margaret Cudd
IPC分类号: A61K31/506 , C07D403/14
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式I的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书所述定义,其制备方法,包括那些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
-
公开(公告)号:US5639911A
公开(公告)日:1997-06-17
申请号:US485248
申请日:1995-06-07
申请人: Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
发明人: Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
IPC分类号: C07C281/12 , C07C281/18 , C07C337/08 , C07C281/00
CPC分类号: C07C337/08 , C07C281/12 , C07C281/18 , C07C2102/06 , C07C2102/08
摘要: Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
摘要翻译: 式I的化合物其中A,X,Z和R 1 -R 5如说明书中所定义,其盐具有有价值的药物性质,尤其对肿瘤有效。 它们是以本身已知的方式准备的。
-
公开(公告)号:US5516775A
公开(公告)日:1996-05-14
申请号:US103493
申请日:1993-08-06
申请人: Jurg Zimmermann , Giorgio Caravatti
发明人: Jurg Zimmermann , Giorgio Caravatti
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04 , A61K31/53 , A61K31/535 , A61K31/54
CPC分类号: A61K31/505
摘要: The invention relates to the use of known N-phenyl-2-pyrimidine derivatives for inhibiting proteinkinase C in warm-blooded animals as antitumor agents. ##STR1## The substituents in formula I are as defined in claim 1.
摘要翻译: 本发明涉及已知的N-苯基-2-嘧啶衍生物在温血动物中抑制蛋白游离酶C作为抗肿瘤剂的用途。 (I)式I中的取代基如权利要求1中所定义。
-
公开(公告)号:US5354761A
公开(公告)日:1994-10-11
申请号:US69660
申请日:1993-06-01
IPC分类号: A61K31/44 , A61K31/4402 , A61K31/4418 , A61P33/02 , C07D213/78 , C07D213/81 , C07D213/83 , C07D401/04
CPC分类号: C07D213/78 , C07D213/81 , C07D213/83
摘要: Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.
摘要翻译: 其中Y,Z,S,S',m,n和R 1 -R 4如说明书中所定义的式I化合物(I)具有有价值的药物性质,并且尤其对抗原生动物感染是有效的。 它们是以本身已知的方式准备的。
-
-
-
-
-
-
-
-
-