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公开(公告)号：US20100247457A1
公开(公告)日：2010-09-30
申请号：US12698172
申请日：2010-02-02
申请人： DOUGLAS ROBERT ANTON , Scott D. Cunningham , Stephen R. Fahnestock , Kari A. Fosser , Hong Wang
发明人： DOUGLAS ROBERT ANTON , Scott D. Cunningham , Stephen R. Fahnestock , Kari A. Fosser , Hong Wang
CPC分类号： A61K8/25 , A61K8/0241 , A61K8/29 , A61K8/64 , A61K8/731 , A61K2800/412 , A61K2800/43 , A61K2800/614 , A61Q11/00 , C07K7/08 , C07K14/001
摘要： Peptide-based reagents comprising at least one tooth surface-binding peptide for delivery of at least one polymer-coated white colorant to the surface of teeth are provided. The peptide-based reagent may comprise at least one tooth-binding peptide coupled to, either directly or through one or more spacers, a polymer-binding peptide capable of binding to the polymeric coating on a polymer-coated white colorant. Methods of delivering a polymer-coated white colorant to a tooth surface are also provided as well as oral care compositions comprising the present peptide-based reagents. The peptide-based reagents may be used in conjunction with at least one polymer-coated white colorant to improve the cosmetic appearance of teeth.
摘要翻译： 提供了包含用于将至少一种聚合物涂覆的白色着色剂递送到牙齿表面的至少一个牙齿表面结合肽的基于肽的试剂。 基于肽的试剂可以包含至少一种与粘合到聚合物涂覆的白色着色剂上的与聚合物涂层结合的聚合物结合肽直接或通过一个或多个间隔物偶联的牙结合肽。 还提供将聚合物涂覆的白色着色剂递送到牙齿表面的方法以及包含本发明的基于肽的试剂的口腔护理组合物。 基于肽的试剂可以与至少一种聚合物涂覆的白色着色剂结合使用以改善牙齿的美容外观。
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公开(公告)号：US20130011356A1
公开(公告)日：2013-01-10
申请号：US13613526
申请日：2012-09-13
IPC分类号： C07K14/435 , A61Q5/06 , A61Q5/12 , A61K8/64
摘要： Hair-binding peptides were isolated for their use in a variety of personal care formulations and applications. The isolation of hair-binding peptides was accomplished by enrichment using mRNA-display selection technology. Hair care compositions comprising peptide-based reagents prepared comprising the hair-binding peptides are also provided.
摘要翻译： 分离发粘结肽用于各种个人护理制剂和应用。 通过使用mRNA显示选择技术的富集来实现毛发结合肽的分离。 还提供了包含由毛发结合肽制备的包含基于肽的试剂的护发组合物。
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公开(公告)号：US07749957B2
公开(公告)日：2010-07-06
申请号：US11696380
申请日：2007-04-04
申请人： Steven Dale Ittel , Scott D. Cunningham , Pierre E. Rouviere , Stephen R. Fahnestock , John P. O'Brien , Eberhard Schneider , Gregor Schurmann , Peter Wagner
发明人： Steven Dale Ittel , Scott D. Cunningham , Pierre E. Rouviere , Stephen R. Fahnestock , John P. O'Brien , Eberhard Schneider , Gregor Schurmann , Peter Wagner
CPC分类号： C07K7/06 , C07K7/08 , C07K14/001 , C07K17/14
摘要： Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.
摘要翻译： 提供了对粘土具有结合亲和力的组合产生的肽。 肽可以用于将有益剂递送到各种粘土表面。
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34.发明申请公开(公告)号：US20090070944A1
公开(公告)日：2009-03-19
申请号：US12198358
申请日：2008-08-26
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively.
摘要翻译： 已经鉴定出以高亲和力结合头发的肽。 描述了通过将毛发结合肽偶联到有益剂形成的基于肽的毛发试剂。 基于肽的毛发试剂包括基于肽的护发素和头发着色剂。 基于肽的护发素和毛发着色剂分别由至少一种与头发调理剂或着色剂偶联的毛发结合肽组成。
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35.发明申请Silk Thread Containing Spider Thread Protein and Silk Worm Producing the Silk Thread 审中-公开丝线螺纹包含丝线蛋白丝和丝虫生产丝线公开(公告)号：US20080287651A1
公开(公告)日：2008-11-20
申请号：US10585742
申请日：2005-01-12
申请人： Shingo Hiramatsu , Hiromitsu Moriyama , Ryota Asaoka , Ken Morita , Takashi Tanaka , Katsushige Yamada , John Philip Obrien , Stephen R. Fahnestock
发明人： Shingo Hiramatsu , Hiromitsu Moriyama , Ryota Asaoka , Ken Morita , Takashi Tanaka , Katsushige Yamada , John Philip Obrien , Stephen R. Fahnestock
IPC分类号： A01K67/04 , C07K14/435 , C12N15/09
CPC分类号： A01K67/0339 , A01K67/04 , A01K2217/05 , A01K2227/706 , A01K2267/01 , C07K14/43518 , C12N15/8509 , D01B7/00
摘要： A transgenic silkworm having transferred therein a gene which encodes spider thread protein having desired properties of high strength and high elasticity while leaving the silkworm fibroin H chain gene intact, by means of utilizing a transposon function, is used to produce in the transgenic silkworm a spider thread protein having the desired properties without lowering the strength or elasticity of silk thread produced by the transgenic silkworm, thereby providing hybrid silk of spider and silk threads having the desired properties.
摘要翻译： 转基因家蚕在转基因家蚕中使用编码具有所需高强度和高弹性性质的蜘蛛丝蛋白的基因，同时通过利用转座子功能留下蚕丝心蛋白H链基因而完整的转基因家蚕 具有所需性质的线蛋白，而不降低由转基因蚕产生的丝线的强度或弹性，从而提供具有所需性质的蜘蛛丝和丝线的混合丝。
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公开(公告)号：US4954618A
公开(公告)日：1990-09-04
申请号：US280963
申请日：1989-03-15
IPC分类号： C07K14/315 , C12N15/31 , C12N15/70 , C12N15/75 , C12P21/02
CPC分类号： C12N15/70 , C07K14/315 , C12N15/75 , C12P21/02 , Y10S530/811 , Y10S530/861
摘要： A cloned gene encoding Protein G, or functionally active portions thereof, vectors containing the cloned gene, and microorganisms transformed by those vectors are disclosed.
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公开(公告)号：US06268169B1
公开(公告)日：2001-07-31
申请号：US08556978
申请日：1995-12-11
IPC分类号： C12N121
CPC分类号： C07K14/43518 , F02B2075/027
摘要： The invention relates to novel spider silk protein analogs derived from the amino acid consensus sequence of repeating units found in the natural spider dragline of Nephila clavipes. More specifically, synthetic spider dragline has been produced from E. coli and Bacillus subtilis recombinant expression systems wherein expressions from E. coli is at levels greater than 1 mg full-length polypeptide per gram of cell mass.
摘要翻译： 本发明涉及衍生自Nephila clavipes天然蜘蛛牵引线中重复单元的氨基酸共有序列的新型蜘蛛丝蛋白类似物。 更具体地，已经从大肠杆菌和枯草芽孢杆菌重组表达系统产生了合成蜘蛛牵引线，其中来自大肠杆菌的表达水平每克细胞质量大于1mg全长多肽。
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38.发明授权Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G 失效编码蛋白G的克隆链球菌基因及其用于构建重组微生物以产生蛋白G的用途
公开(公告)号：US5229492A
公开(公告)日：1993-07-20
申请号：US540169
申请日：1990-06-19
IPC分类号： C07K14/315 , C12N15/70 , C12N15/75
CPC分类号： C07K14/315 , C12N15/70 , C12N15/75
摘要： Protein G variants are disclosed. These protein G variants have the immunoglobulin binding properties of protein G. Also disclosed is the preparation of the protein G variants by expression from hosts transformed with a gene encoding the protein G variants.
摘要翻译： 公开了蛋白G变体。 这些蛋白G变体具有蛋白G的免疫球蛋白结合特性。还公开了通过用编码蛋白G变体的基因转化的宿主的表达来制备蛋白G变体。
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公开(公告)号：US4828994A
公开(公告)日：1989-05-09
申请号：US733379
申请日：1985-05-13
CPC分类号： C12N9/54 , C12N15/75 , C12N15/90 , Y10S435/839
摘要： Bacillus strains having reduced levels of extracellular protease are produced by replacing the native chromosomal DNA sequence comprising the gene for an extracellular protease, such as subtilisin, with a partially homologous DNA sequence having an inactivating DNA segment inserted therein. The strains are useful as hosts for the expression and secretion of heterologous polypeptides or proteins.
摘要翻译： 通过用包含插入其中的失活DNA片段的部分同源DNA序列替换包含细胞外蛋白酶基因例如枯草杆菌蛋白酶的天然染色体DNA序列来产生细胞外蛋白酶水平降低的芽孢杆菌菌株。 该菌株可用作异源多肽或蛋白质的表达和分泌的宿主。
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公开(公告)号：US08287845B2
公开(公告)日：2012-10-16
申请号：US12629069
申请日：2009-12-02
摘要： Hair-binding peptides were isolated for their use in a variety of personal care formulations and applications. The isolation of hair-binding peptides was accomplished by enrichment using mRNA-display selection technology. Hair care compositions comprising peptide-based reagents prepared comprising the hair-binding peptides are also provided.
摘要翻译： 分离发粘结肽用于各种个人护理制剂和应用。 通过使用mRNA显示选择技术的富集来实现毛发结合肽的分离。 还提供了包含由毛发结合肽制备的包含基于肽的试剂的护发组合物。
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