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31.发明申请Pyrazine Derivatives with Extended Conjugation and Methods of Using the same in Optical Applications 有权具有扩展共轭的吡嗪衍生物及其在光学应用中的使用方法公开(公告)号：US20100233091A1
公开(公告)日：2010-09-16
申请号：US12305700
申请日：2007-06-20
IPC分类号： A61K49/00 , A61K31/497 , A61K31/5377 , A61K31/4965 , A61P13/12
CPC分类号： C07D405/04 , A61K49/0021 , C07D241/12 , C07D241/20 , C07D241/24 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/04 , C07D417/04 , C07D473/18 , C07D473/34
摘要： The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically acceptable composition and utilized in medical (e.g., diagnostic imaging) procedures.
摘要翻译： 本发明涉及能够吸收和发出可见光和/或近红外光谱中的光谱能量的吡嗪衍生物。 本发明的吡嗪衍生物可以以药学上可接受的组合物的形式施用于患者，并用于医学（例如，诊断成像）程序中。
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公开(公告)号：US20100021382A1
公开(公告)日：2010-01-28
申请号：US12351891
申请日：2009-01-12
申请人： Richard B. Dorshow , John Freskos , William L. Neumann , Amruta Reddy Poreddy , Raghavan Rajagopalan
发明人： Richard B. Dorshow , John Freskos , William L. Neumann , Amruta Reddy Poreddy , Raghavan Rajagopalan
IPC分类号： A61K49/00 , C07D241/20 , A61P13/12
CPC分类号： C07D241/28
摘要： Disclosed herein are pyrazine derivatives and methods of using the same.
摘要翻译： 本文公开的是吡嗪衍生物及其使用方法。
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公开(公告)号：US07556797B2
公开(公告)日：2009-07-07
申请号：US10653728
申请日：2003-09-02
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
CPC分类号： A61K31/405 , C07D209/08 , C07D209/18 , C07D209/24 , C07D209/60 , C09B23/0025 , C09B23/0066 , C09B23/0075 , C09B23/08
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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公开(公告)号：US20090036502A1
公开(公告)日：2009-02-05
申请号：US12281156
申请日：2007-03-02
CPC分类号： C07D513/04
摘要： Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites.
摘要翻译： 噻二唑化合物，组合物，生物缀合物以及在靶位点靶向和光活化的方法。
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公开(公告)号：US20080275017A1
公开(公告)日：2008-11-06
申请号：US12173235
申请日：2008-07-15
申请人： Raghavan Rajagopalan , Gary L. Cantrell , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
发明人： Raghavan Rajagopalan , Gary L. Cantrell , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
IPC分类号： A61K31/565 , A61K31/165 , A61K31/473 , A61K31/352
CPC分类号： A61K41/0057
摘要： Novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest.
摘要翻译： 新型次氯酸盐衍生物及其生物缀合物用于肿瘤和其他病变的光疗。 本发明的次氯酸盐被设计成吸收电磁光谱的低能量紫外线，可见光或近红外（NIR）区域。 光疗效应是由自由基（在次硫酸盐部分的光分解产生的反应性中间体）与感兴趣的组织的直接相互作用引起的。
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36.发明授权公开(公告)号：US07252815B2
公开(公告)日：2007-08-07
申请号：US10847256
申请日：2004-05-17
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
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公开(公告)号：US07235685B2
公开(公告)日：2007-06-26
申请号：US09898887
申请日：2001-07-03
申请人： Raghavan Rajagopalan , Gary L. Cantrell , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
发明人： Raghavan Rajagopalan , Gary L. Cantrell , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
IPC分类号： C07K313/08
CPC分类号： A61K41/0057
摘要： The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest.
摘要翻译： 本发明公开了用于肿瘤和其他病变光疗的新型次氯酸盐衍生物及其生物缀合物。 本发明的次氯酸盐被设计成吸收电磁光谱的低能量紫外线，可见光或近红外（NIR）区域。 光疗效应是由自由基（在次硫酸盐部分的光分解产生的反应性中间体）与感兴趣的组织的直接相互作用引起的。
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公开(公告)号：US07175831B2
公开(公告)日：2007-02-13
申请号：US10751232
申请日：2004-01-02
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Hermo N. Jimenez , Muthunadar P. Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Hermo N. Jimenez , Muthunadar P. Periasamy
CPC分类号： A61K49/0032 , C09B23/02
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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39.发明授权Pathological tissue detection and treatment employing targeted benzoindole optical agents 失效使用靶向苯并吲哚光学剂的病理组织检测和治疗公开(公告)号：US06761878B2
公开(公告)日：2004-07-13
申请号：US09978725
申请日：2001-10-17
IPC分类号： A61B1000
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译： 公开了新型肿瘤特异性光疗法和光诊断剂。 化合物由用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 抗体肽组成。这些元素的组合充分利用了独特且有效的性质 每个组件进行有效的病人护理管理。
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40.发明授权公开(公告)号：US06733744B1
公开(公告)日：2004-05-11
申请号：US09688946
申请日：2000-10-16
IPC分类号： A61B1000
CPC分类号： C09B23/0025 , A61K31/405 , C07D209/18 , C07D209/24 , C07D209/60 , C09B23/0066 , C09B23/0075 , C09B23/08
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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