公开(公告)号：US06972315B2

公开(公告)日：2005-12-06

申请号：US10199434

申请日：2002-07-19

申请人： Richard A. Gross ,  Ajay Kumar ,  Bhanu Kalra

发明人： Richard A. Gross ,  Ajay Kumar ,  Bhanu Kalra

IPC分类号： C08G63/78 ,  C08G63/87 ,  C08G63/02

CPC分类号： C08G63/87 ,  C08G63/78

摘要： A method for enzymatic condensation polymerization by combining a preselected quantity of an enzyme, a diol and/or a polyol, and a diacid in a reaction vessel; heating the reaction vessel containing the enzyme, the diol or polyol, and the diacid to a preselected temperature; and maintaining the reaction vessel containing the enzyme, the diol and/or polyol, and the diacid at the preselected temperature for a preselected time, thereby producing a condensation polymer.

摘要翻译： 一种通过将预选量的酶，二醇和/或多元醇与二酸在反应容器中组合来进行酶缩缩聚合的方法; 将含有酶，二醇或多元醇的反应容器和二酸加热至预选温度; 并在预选的温度下保持含有酶，二醇和/或多元醇和二酸的反应容器预选的时间，从而制备缩聚物。

公开(公告)号：US06566469B1

公开(公告)日：2003-05-20

申请号：US09602649

申请日：2000-06-22

申请人： David Kaplan ,  Graham Swift ,  Richard A. Gross ,  Bhanu Kalra

发明人： David Kaplan ,  Graham Swift ,  Richard A. Gross ,  Bhanu Kalra

IPC分类号： C08F430

CPC分类号： C12P1/00

摘要： A method for polymerization of substituted ethylene monomers in an enzyme-mediated process is disclosed. The reaction proceeds under mild conditions with a wide variety of monomers, and is capable of producing stereoregular polymers. In certain embodiments, no organic solvent is necessary.

摘要翻译： 公开了在酶介导的方法中聚合取代的乙烯单体的方法。 该反应在温和条件下与各种各样的单体进行，并且能够产生立体有规聚合物。 在某些实施方案中，不需要有机溶剂。

公开(公告)号：US06486295B1

公开(公告)日：2002-11-26

申请号：US09489772

申请日：2000-01-24

申请人： Richard A. Gross ,  Ajay Kumar

发明人： Richard A. Gross ,  Ajay Kumar

IPC分类号： C08G6308

CPC分类号： C08G63/823 ,  C08G64/30

摘要： A method to regulate copolymer structure using lipase catalyzed transesterification reactions, by selecting a first reactant from the group consisting of polymers and monomers, selecting a second reactant from the group consisting of polymers and monomers, and combining the first reactant, the second reactant, and a lipase in a reaction vessel and allowing the ensuing transesterification reaction to proceed resulting in a polymer. The method allows one to regulate the copolymer repeat unit sequence distribution, and may take place with chain-length specificity such that activation of chains for exchange reactions with other chains or monomers can occur preferentially at certain locations along the chain.

摘要翻译： 一种通过使用脂肪酶催化的酯交换反应来调节共聚物结构的方法，通过从由聚合物和单体组成的组中选择第一反应物，从第一反应物，第二反应物和 在反应容器中的脂肪酶，并允许随后的酯交换反应进行，得到聚合物。 该方法允许调节共聚物重复单元序列分布，并且可以以链长特异性进行，使得与其它链或单体的交换反应的链的活化可优先在沿着链的某些位置发生。

公开(公告)号：US06477743B1

公开(公告)日：2002-11-12

申请号：US09929389

申请日：2001-08-14

申请人： Richard A. Gross ,  Walter W. Peterson

发明人： Richard A. Gross ,  Walter W. Peterson

IPC分类号： B65D3500

CPC分类号： B65D51/226 ,  B65D47/244 ,  B65D2251/0025 ,  B65D2251/0056 ,  B65D2251/0093

摘要： A dispensing closure system is provided for a container. The system includes a body for extending from the container at the container opening. The body includes a base, a conduit that is reciprocatable relative to the base, and a flexible wall joining the conduit to the base. The conduit includes a dispensing aperture and a first seal surface. A spout is carried on, and is rotatable relative to, the body. The spout includes a dispensing orifice and a second seal surface for engaging the first seal surface. The body and spout together define a rotary-to-linear motion translation drive system that is (1) responsive to the rotation of the spout in one direction for moving the conduit in a first direction to a closed position, and (2) responsive to the rotation of the spout in the opposite direction for moving the conduit in a second direction opposite from the first direction to an open position.

摘要翻译： 为容器提供分配封闭系统。 该系统包括在容器开口处从容器延伸的主体。 主体包括基部，相对于基部可往复运动的导管和将导管连接到基部的柔性壁。 导管包括分配孔和第一密封表面。 喷嘴被承载并且可相对于身体旋转。 喷口包括分配孔和用于接合第一密封表面的第二密封表面。 主体和喷口一起限定了旋转到直线的运动平移驱动系统，其是（1）响应于喷嘴在一个方向上的旋转以便将导管沿第一方向移动到关闭位置，以及（2）响应于 喷嘴在相反方向上的旋转，用于使管道沿与第一方向相反的第二方向移动到打开位置。

公开(公告)号：US06439429B1

公开(公告)日：2002-08-27

申请号：US09899771

申请日：2001-07-05

申请人： Richard A. Gross

发明人： Richard A. Gross

IPC分类号： B65D3500

CPC分类号： B65D75/5883 ,  B65D41/34 ,  B65D2101/0038 ,  B65D2575/583

摘要： A tamper-evident dispensing structure is provided for being sealed to a collapsible pouch. The structure includes a fitment and a lid structure which are each separately molded and which can be subsequently non-releasably attached. The fitment is adapted to be sealed to a periphery of the pouch at an opening in the pouch. The fitment has a receiver and has at least one dispensing flow passage through the fitment. The lid structure includes (1) a base for being fixedly and non-releasably attached to the fitment receiver, (2) a cap for being sealingly and removably mounted on the fitment to occlude the dispensing passage, and (3) at least a first frangible web connecting the cap to the base for accommodating separation of the cap from the base.

摘要翻译： 提供了一种用于密封到可折叠袋的防拆装置分配结构。 该结构包括配件和盖子结构，它们各自单独地模制并且随后可以不可释放地附接。 配件适于在袋的开口处密封到袋的周边。 配件具有接收器并且具有穿过配件的至少一个分配流动通道。 盖结构包括（1）用于固定和不可释放地附接到配件接收器的基座，（2）用于密封地和可拆卸地安装在配件上以闭塞分配通道的盖，以及（3）至少第一 将盖连接到基座上以容纳盖与基座分离的易碎腹板。

公开(公告)号：US06398077B1

公开(公告)日：2002-06-04

申请号：US09502630

申请日：2000-02-11

申请人： Richard A. Gross ,  Daniel G. Schantz ,  Timothy R. Socier ,  Fred H. Martin ,  Julie M. Grissmeyer ,  Duncan Toll

发明人： Richard A. Gross ,  Daniel G. Schantz ,  Timothy R. Socier ,  Fred H. Martin ,  Julie M. Grissmeyer ,  Duncan Toll

IPC分类号： B67D360

CPC分类号： B65D81/3283 ,  B65D47/2031 ,  B65D47/242

摘要： A dispensing system is provided for two, constituent, fluent materials which are stored separately and then combined in a dispensing process to form a combination product. The dispensing system includes a container having at least two interior storage chambers, and each chamber has a separate discharge opening. Associated with each discharge opening is a separate, flexible valve. Each valve has an initially closed dispensing orifice which opens in response to a differential between the pressure acting against the side of the closed valve facing toward the associated discharge opening and the pressure acting against the side of the closed valve facing away from the associated discharge opening. In a preferred embodiment, a top is provided downstream of the valve. The top is movable between (1) a close position to occlude a dispensing flow path downstream of the valves, and (2) an open position which permits flow to be discharged from the system.

摘要翻译： 提供分配系统用于分开存储的两种成分流通材料，然后在分配过程中组合以形成组合产品。 分配系统包括具有至少两个内部储存室的容器，并且每个室具有单独的排出口。 与每个排放口相关联的是一个单独的柔性阀。 每个阀具有初始闭合的分配孔，其响应于作用在朝向相关联的排出开口的关闭阀的侧面的压力与作用在离开相关联的排放开口的关闭阀侧的压力之间的差异而打开 。 在优选实施例中，顶部设置在阀的下游。 顶部可在（1）闭合位置之间移动，以封闭阀下游的分配流动路径，以及（2）允许流动从系统排出的打开位置。

公开(公告)号：US5440007A

公开(公告)日：1995-08-08

申请号：US232870

申请日：1994-04-25

申请人： Richard A. Gross ,  John E. Kemnitzer ,  Stephen P. McCarthy

发明人： Richard A. Gross ,  John E. Kemnitzer ,  Stephen P. McCarthy

IPC分类号： C08G63/08 ,  C08G63/82 ,  C08L67/04

CPC分类号： C08G63/823 ,  C08G63/08 ,  C08L67/04

摘要： High molecular weight, biodegradable polymers of substituted-poly(.beta.-propioesters), wherein the repeat unit sequences have a predominantly syndiotactic arrangement and a method of forming such polymers are disclosed. The method includes exposing a substituted-.beta.-propiolactone to a tin-based organometallic catalyst for a sufficient combination of time and temperature to form the predominantly syndiotactic substituted-poly(.beta.-propioester).

摘要翻译： 公开了取代聚（β-丙酰酯）的高分子量可生物降解的聚合物，其中重复单元序列具有主要的间同立构排列和形成这种聚合物的方法。 该方法包括将取代的β-丙内酯暴露于锡基有机金属催化剂以充分地组合时间和温度以形成主要间同立构取代的聚（β-丙酸酯）。

公开(公告)号：US20140051780A1

公开(公告)日：2014-02-20

申请号：US13587292

申请日：2012-08-16

申请人： Richard A. Gross

发明人： Richard A. Gross

IPC分类号： C08G63/06

CPC分类号： C08G63/06 ,  C08G63/08 ,  C08G63/60 ,  C08L67/00 ,  C08L67/04

摘要： The present invention relates to aliphatic or aliphatic-aromatic polyesters and copolyesters comprised of biobased ω-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The copolyesters of the present invention may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ω-hydroxyfatty acids that comprise the polyesters and copolyesters of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources. The polyesters of the present invention may contain various amounts and types of ω-carboxyfatty acids depending on the engineered yeast strain used for the bioconversion as well as the feedstock(s) used.

摘要翻译： 本发明涉及由生物基的ω-羟基脂肪酸或其衍生物组成的脂族或脂肪族 - 芳族聚酯和共聚酯，其制备方法及其具有改进性能的组合物。 本发明的共聚酯还可以含有另外的组分，其可以选自由合成和天然来源获得的脂族或芳族二酸，二醇和羟基酸。 包含本发明的聚酯和共聚酯的生物基的ω-羟基脂肪酸是使用来自各种来源的纯脂肪酸，脂肪酸混合物，纯脂肪酸酯，脂肪酸酯和甘油三酯的混合物的发酵方法制备的。 根据用于生物转化的工程酵母菌株以及所使用的原料，本发明的聚酯可以含有各种量的和类型的ω-羧基脂肪酸。

公开(公告)号：US20130131222A1

公开(公告)日：2013-05-23

申请号：US13634066

申请日：2011-03-11

申请人： Richard A. Gross

发明人： Richard A. Gross

IPC分类号： C12P7/64 ,  C08G18/36 ,  C08L75/06

CPC分类号： C08G18/36 ,  C08G18/4288

摘要： The present invention relates to polyurethane polymers comprising as part of its polymer backbone biobased ω-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The polyurethanes of the present invention are prepared from copolyester prepolymers comprising the biobased ω-hydroxyfatty acids that may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ω-hydroxyfatty acids that comprise the polyurethanes and copolyester prepolymers of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources. The copolyester prepolymers of the present invention may contain various amounts and types of ω-carboxyfatty acids depending on the engineered yeast strain used for the bioconversion as well as the feedstock(s) used.

摘要翻译： 本发明涉及包含作为其聚合物骨架生物基的ω-羟基脂肪酸或其衍生物的一部分的聚氨酯聚合物，其制备方法及其具有改进性能的组合物。 本发明的聚氨酯由包含生物基的ω-羟基脂肪酸的共聚酯预聚物制备，其还可以含有可以选自合成和天然来源获得的脂族或芳族二酸，二醇和羟基酸的另外的组分。 包含本发明的聚氨酯和共聚酯预聚物的生物基ω-羟基脂肪酸是使用来自各种来源的纯脂肪酸，脂肪酸混合物，纯脂肪酸酯，脂肪酸酯和甘油三酯的混合物的发酵方法制备的。 根据用于生物转化的工程酵母菌株以及所使用的原料，本发明的共聚酯预聚物可含有各种量和类型的ω-羧基脂肪酸。

公开(公告)号：US20100130442A1

公开(公告)日：2010-05-27

申请号：US12598363

申请日：2008-05-06

申请人： Raj Wadgaonkar ,  Richard A. Gross ,  Daniel Butnariu ,  Vipul Patel ,  Kaumudi Somnay

发明人： Raj Wadgaonkar ,  Richard A. Gross ,  Daniel Butnariu ,  Vipul Patel ,  Kaumudi Somnay

IPC分类号： A61K31/7016 ,  A61P11/00 ,  C07H3/04

CPC分类号： A61K31/70

摘要： Techniques for lung injury treatment are provided. For example, a technique for treating a lung injury in a patient includes the step of administering a therapeutically effective amount of a sophorolipid to the patient.

摘要翻译： 提供肺损伤治疗技术。 例如，用于治疗患者的肺损伤的技术包括向患者施用治疗有效量的槐糖脂的步骤。