Biodegradable and hydrodegradable diblock copolymers composed of poly(.beta
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    7.
    发明授权
    Biodegradable and hydrodegradable diblock copolymers composed of poly(.beta . 失效
    由聚(β-羟基链烷酸酯)和聚(内酯)或聚(丙交酯)链段组成的可生物降解和可降解的二嵌段共聚物

    公开(公告)号:US5439985A

    公开(公告)日:1995-08-08

    申请号:US98709

    申请日:1993-07-28

    IPC分类号: C08G63/08 C08G63/84

    CPC分类号: C08G63/08

    摘要: A biodegradable and hydrodegradable diblock copolymer includes a naturally-occurring poly(.beta.-alkanoate) component and a chemically synthesized polyester component formed by ring-opening polymerization. A method of forming the biodegradable and hydrodegradable diblock copolymer having a poly(.beta.-hydroxyalkanoate) component and a chemically synthesized polyester component includes exposing a naturally-occurring poly(.beta.-hydroxyalkanoate) to alcoholysis and then to a trialkyl metal to form a dialkyl metal poly(.beta.-hydroxyalkanoate) macroinitiator. The macroinitiator is then reacted with a lactone or lactide reactant to form the biodegradable and hydrodegradable diblock copolymer.

    摘要翻译: 可生物降解和可降解的二嵌段共聚物包括天然存在的聚(β-链烷酸酯)组分和通过开环聚合形成的化学合成的聚酯组分。 形成具有聚(β-羟基链烷酸酯)组分和化学合成的聚酯组分的可生物降解和可降解的二嵌段共聚物的方法包括将天然存在的聚(β-羟基链烷酸酯)暴露于醇解,然后暴露于三烷基金属以形成二烷基金属 聚(β-羟基链烷酸酯)大分子引发剂。 然后将大引发剂与内酯或丙交酯反应物反应以形成可生物降解和可降解的二嵌段共聚物。