-
公开(公告)号：US6159980A
公开(公告)日：2000-12-12
申请号：US929935
申请日：1997-09-15
IPC分类号： A61K31/495 , A61K31/497 , A61K31/53 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D241/18 , C07D241/20 , C07D253/07 , C07D401/12 , C07D405/12
CPC分类号： C07D241/20 , C07D241/18 , C07D253/07 , C07D401/12 , C07D405/12
摘要： Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
摘要翻译： 式（I）的促肾上腺皮质激素释放因子（CRF）拮抗剂及其在治疗精神疾病和神经系统疾病中的用途，包括主要抑郁症，焦虑相关疾病，创伤后应激障碍，核上性麻痹和进食障碍。
-
公开(公告)号：US5597034A
公开(公告)日：1997-01-28
申请号：US270193
申请日：1994-07-01
申请人： Charles R. Barker, III , Richard E. Olson , Stephen E. Lindquist , Massimo Hartsarich , David A. Cease , Robert S. Sobolewski
发明人： Charles R. Barker, III , Richard E. Olson , Stephen E. Lindquist , Massimo Hartsarich , David A. Cease , Robert S. Sobolewski
IPC分类号： H01L23/467 , F28F7/00
CPC分类号： H01L23/467 , H01L2924/0002
摘要： A fan heatsink assembly is provided to afford cooling for electronic components mounted on a circuit board. The assembly includes a blower mounted on top of a specially shaped heatsink, the heatsink having a truncated hyperbolic shaped central member, with fins radially emanating from the center. The blower draws air in through the area between the fins, up the curved central portion and into the blower assembly where it is then exited out the sides of the fan. The fins may be smooth or textured, straight or curved. The fan heatsink assembly is attached to the device to be cooled. Heat is transferred from the electronic component, into the heat dissipating member where the fan causes air to be drawn up between the fins and along the curved center portion, removing heat from the heat dissipating member and the electronic component.
摘要翻译： 提供风扇散热器组件以为安装在电路板上的电子部件提供冷却。 组件包括安装在特殊形状的散热器顶部的鼓风机，散热器具有截头双曲形中心构件，其中心从中心径向散发。 鼓风机将空气吸入翅片之间的区域，向上弯曲的中心部分并进入鼓风机组件，然后从风扇的侧面排出。 翅片可以是光滑的或纹理的，直的或弯曲的。 风扇散热器组件连接到要冷却的设备。 热量从电子部件转移到散热构件中，在该散热构件中，风扇使得空气在翅片之间并沿着弯曲的中心部分被拉伸，从散热构件和电子部件移除热量。
-
公开(公告)号：US4965281A
公开(公告)日：1990-10-23
申请号：US423256
申请日：1989-10-18
IPC分类号： A01N43/653 , C07C33/48 , C07D249/08 , C07D249/10 , C07D249/12 , C07D303/08 , C07D405/04 , C07D521/00
CPC分类号： C07D249/08 , A01N43/653 , C07C33/483 , C07D231/12 , C07D233/56 , C07D249/10 , C07D249/12 , C07D303/08 , C07D405/04
摘要： Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the proviso that when E is oxygen; R, R.sup.1 are not halogen; andL, A, B, Q, R.sup.2, R.sup.3, R.sup.4 and n are as defined in the specification.
-
公开(公告)号：US4965280A
公开(公告)日：1990-10-23
申请号：US423250
申请日：1989-10-18
IPC分类号： A01N43/653 , C07C33/48 , C07D249/08 , C07D249/10 , C07D249/12 , C07D303/08 , C07D405/04 , C07D521/00
CPC分类号： C07D249/08 , A01N43/653 , C07C33/483 , C07D231/12 , C07D233/56 , C07D249/10 , C07D249/12 , C07D303/08 , C07D405/04
摘要： Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the proviso that when E is oxygen; R, R.sup.1 are not halogen; andL, A, B, Q, R.sup.2, R.sup.3, R.sup.4 and n are as defined in the specification.
摘要翻译： 提供了抗真菌甲醇，特别是α-苯乙烯基甲醇和相应的环氧甲醇。 这些甲醇化合物具有下式：其中E是一个键或氧原子，条件是当E是氧时，它是一种药学上或农业上合适的盐， R，R1不是卤素; L，A，B，Q，R2，R3，R4和n如说明书中所定义。
-
35.发明授权Aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳氧基和杂芳氧基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08987252B2
公开(公告)日：2015-03-24
申请号：US12598912
申请日：2008-05-08
IPC分类号： A61K31/55 , C07D223/16 , C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04
CPC分类号： C07D471/04 , C07D223/16 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S configuration and the substituents X and R1—R9 are as defined herein.
摘要翻译： 本发明的芳氧基 - 和杂芳氧基取代的四氢苯并吖庚因衍生物化合物由具有以下结构的式（I）（AE）表示，其中指定为*的碳原子为R或S构型，取代基X和R 1 -R 9为 如本文所定义。
-
36.发明授权公开(公告)号：US08309577B2
公开(公告)日：2012-11-13
申请号：US12607354
申请日：2009-10-28
申请人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A01N43/40 , A61K31/445 , C07D413/00
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
-
公开(公告)号：US20120028994A1
公开(公告)日：2012-02-02
申请号：US13013373
申请日：2011-01-25
申请人： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
发明人： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC分类号： A61K31/517 , C07D401/14 , A61P35/00 , A61P25/28 , A61P25/00 , A61P27/02 , C07D403/12 , C07D401/12
CPC分类号： A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
摘要： The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
摘要翻译： 本公开提供了一系列式（I）的化合物，其调节和淀粉样蛋白肽（＆bgr; -AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
-
38.发明授权Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production 失效α-（N-亚磺酰氨基）乙酰胺化合物作为β-淀粉样蛋白肽生产的抑制剂公开(公告)号：US08093276B2
公开(公告)日：2012-01-10
申请号：US12407029
申请日：2009-03-19
IPC分类号： A61K31/4245 , A61P25/00
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides a method for the treatment of head trauma, traumatic brain injury, and/or dementia pugilistica comprising administering a therapeutically effective amount of (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide.
摘要翻译： 本发明提供一种治疗头部创伤，创伤性脑损伤和/或痴呆症的方法，包括给予治疗有效量的（2R）-2 - [[（4-氯苯基）磺酰基] [[2-氟 - 4-（1,2,4-恶二唑-3-基）苯基]甲基]氨基] -5,5,5-三氟戊酰胺。
-
![Azabicyclo[2.2.1]Heptane Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands](/abs-image/US/2011/10/27/US20110263605A1/abs.jpg.150x150.jpg)
39.发明申请Azabicyclo[2.2.1]Heptane Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands 有权氮杂双环[2.2.1]庚烷化合物作为α-7烟碱乙酰胆碱受体配体公开(公告)号：US20110263605A1
公开(公告)日：2011-10-27
申请号：US12907122
申请日：2010-10-19
申请人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
发明人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
IPC分类号： A61K31/439 , C07D487/00 , A61K31/506 , A61K31/497 , A61K31/53 , A61P1/00 , A61P25/28 , A61P25/18 , A61P19/02 , A61P1/04 , A61P3/10 , C07D498/20 , A61K31/519
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括Ia，Ib，Ic或Id，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
-
40.发明授权Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production 有权结合氘作为β淀粉样蛋白肽生产抑制剂的α-（N-亚磺酰氨基）乙酰胺化合物公开(公告)号：US08044077B2
公开(公告)日：2011-10-25
申请号：US12723936
申请日：2010-03-15
IPC分类号： A61K31/4245 , C07D271/06 , A61P25/28
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present disclosure provides novel deuterated alpha-(N-sulfonamido)acetamide compounds, their pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease, head trauma, traumatic brain injury, and/or dementia pugilistica and/or other conditions associated with β-amyloid peptide.
摘要翻译： 本公开提供了新的氘代α-（N-亚磺酰氨基）乙酰胺化合物，其药物组合物及其制备方法和治疗阿尔茨海默氏病，头部创伤，创伤性脑损伤和/或痴呆症和/或其他相关病症的方法 与β-淀粉样蛋白肽。
-
-
-
-
-
-
-
-
-
搜索结果
111 条记录 (耗时 0.054 秒)
