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31.发明授权Apparatus and method for separating and isolating components of a biological fluid 有权用于分离和分离生物流体组分的装置和方法公开(公告)号：US08511479B2
公开(公告)日：2013-08-20
申请号：US13374988
申请日：2012-01-24
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
摘要翻译： 一种用于分离和分离生物流体组分的装置，包括用于容纳待处理流体的容器，用于在提供与其进行填充和抽出连通的同时关闭容器的管帽组件;设置在容器内用于漏斗和控制生物 流体流入浮子内的反向圆顶形隔离室，并控制生物流体流出隔离室，用于在离心过程中进行隔离室内至少一种组分或分离的生物流体流的密封隔离 处理。 所述装置还包括用于连接设置在所述浮子组件内的抽吸通道的柔性管和所述管帽组件的抽吸阀，用于允许至少提取在所述室内封装或隔离的所述一个部件或部件。
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公开(公告)号：US08506823B2
公开(公告)日：2013-08-13
申请号：US13374983
申请日：2012-01-26
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
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公开(公告)号：US20120065048A1
公开(公告)日：2012-03-15
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01D21/26
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US20120065047A1
公开(公告)日：2012-03-15
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译： 离心容器包括包含内部空间的外壁。 大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。 这些地区通过大坝连接在一起。 大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。 容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且为了收集样品的较高密度部分而优化的体积。 供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。
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公开(公告)号：US5160841A
公开(公告)日：1992-11-03
申请号：US805570
申请日：1991-12-12
申请人： John R. Chapman , David S. Jones
发明人： John R. Chapman , David S. Jones
摘要： An ion source for a mass spectrometer has a continuous flow probe (FIG. 2) having a mesh defining a surface, a capillary for supplying liquid sample to the surface and a porous body disposed at the periphery of the mesh. An ion source generates a beam of ionising radiation to which sample supplied to the surface is exposed. Sample supplied by the inlet tube spreads across the surface and surplus sample reaching the periphery of the mesh is absorbed by the porous body.
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公开(公告)号：US4569243A
公开(公告)日：1986-02-11
申请号：US725820
申请日：1985-04-22
CPC分类号： G05G5/18 , G05G11/00 , Y10T74/20006 , Y10T74/2146
摘要： A linear no-back device for transmitting bi-directional linear motion from an input shaft to an output shaft while preventing motion of the output shaft independently of the input shaft and enabling movement of the input shaft when the output shaft is jammed. The linear no-back device has a fixed member having a bore with a pair of spring discs loosely mounted on the output shaft and having flexible ears at the periphery thereof in engagement with a wall of the bore. A pair of spaced-apart stop rings on the output shaft limit separating movement of the spring discs axially of the output shaft and a preloaded compression coil spring urges the spring discs away from each other. Actuating members associated with the input shaft are effective upon movement of the input shaft in either linear direction to effectively disengage the spring discs from the wall of the bore and transmit motion of the input shaft to the output shaft through a motion-transmitting connection including the preloaded compression coil spring. Further compression of the preloaded compression coil spring enables movement of the input shaft relative to the output shaft when the latter is jammed.
摘要翻译： 一种用于将输入轴双向直线运动传递到输出轴的线性无背装置，同时防止输出轴独立于输入轴的运动，并且当输出轴卡住时能够使输入轴运动。 线性无背装置具有固定构件，该固定构件具有孔，其中一对弹簧盘松散地安装在输出轴上并且在其周边处具有与孔的壁接合的柔性耳。 输出轴上的一对间隔开的止动环限制了分离出输出轴轴向的弹簧片的运动和预加载的压缩螺旋弹簧，促使弹簧片彼此远离。 与输入轴相关联的致动构件在输入轴沿直线方向移动时有效，以有效地将弹簧盘与孔的壁分离，并且通过运动传递连接将输入轴传递到输出轴，包括 预压缩螺旋弹簧。 预加载的压缩螺旋弹簧的进一步的压缩使得输入轴相对于输出轴在其被卡住时能够移动。
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公开(公告)号：US4556131A
公开(公告)日：1985-12-03
申请号：US541358
申请日：1983-10-11
申请人： John R. Chapman
发明人： John R. Chapman
IPC分类号： F16D43/208 , F16D59/00
CPC分类号： F16D43/208 , F16D59/00
摘要： According to the invention a housing is provided defining concentric, cylindrical first and second braking surfaces. First and second cylindrical, concentric torque tubes are provided within the annular gap between braking surfaces and are each split lengthwise sufficiently to permit slight, radial deflection into engagement with the respective braking surfaces on the housing to which it is adjacent. An input carrier is provided to transmit the torque between a prime mover and an output position on the torque tubes. The carrier has a plurality of fingers which project between and are aligned axially with the torque tubes. Each of the torque tubes is operatively engaged with an output member so that the torque imparted by a common drive to each output can be simultaneously controlled.
摘要翻译： 根据本发明，提供限定同心圆柱形的第一和第二制动表面的壳体。 第一和第二圆柱形的同心扭矩管设置在制动表面之间的环形间隙内，并且每个分别纵向地分开，以允许轻微的径向偏转与其相邻的壳体上的相应制动表面接合。 提供输入载体以在原动机和扭矩管上的输出位置之间传递扭矩。 载体具有多个指状物，其在扭矩管之间突出并且与扭矩管轴向对准。 每个扭矩管可操作地与输出构件接合，使得可以同时控制由公共驱动给每个输出赋予的扭矩。
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