摘要:
An ion source for a mass spectrometer has a continuous flow probe (FIG. 2) having a mesh defining a surface, a capillary for supplying liquid sample to the surface and a porous body disposed at the periphery of the mesh. An ion source generates a beam of ionising radiation to which sample supplied to the surface is exposed. Sample supplied by the inlet tube spreads across the surface and surplus sample reaching the periphery of the mesh is absorbed by the porous body.
摘要:
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要:
A method for enabling seamless transitions for a cinema presentation package, wherein the cinema presentation package includes pre-shows, trailers, live events, and main features, the steps include determining the requirements of specific protocols corresponding to the cinema presentation that will affect transitioning between the pre-shows, trailers, live events, and main features. Transition behaviors have to be identified between the pre-shows, trailers, live events, and main features that form the cinema presentation package. Flexibility exists in displaying the cinema presentation package, and yet the pre-shows, trailers, live events, and main features are displayed according to the specific protocols and transition rules associated with the specific protocols.
摘要:
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要:
A method is described for scheduling a playlist from digital content supplied to a server in a multi-screen digital cinema theater. The playlist includes digital content stored in the server and that is subsequently projected in the digital cinema theater. The method includes: (a) generating and displaying a table of playlists currently available for scheduling; (b) generating and displaying a schedule table showing a schedule view for each screen as an elongated timeline bar representing a time dimension. The method further includes: (c) selecting a playlist from the table of playlists and specifying a scheduled start time and a selected screen; and (d) updating the schedule table by inserting the selected playlist as an elongated element into the elongated timeline bar for the selected screen, whereby the updated schedule table is used to schedule the selected playlist for the selected screen.
摘要:
Haloaryl compounds bearing a defined functional group or precursor are metalated with either Sn(n-Bu).sub.3 or SnMe.sub.3. The resulting aryltin compound may be transmetalated in site-specific reaction with one of the following organometallic groups: HgX.sub.2, Hg(OAc).sub.2, BX.sub.3, or BZ.sub.3, wherein X is Cl, Br, or I, and Z is alkyl or alkoxy. The stannylated or otherwise metalated compounds are subsequently radiohalogenated via a demetalation reaction. The Stannylated or otherwise metalated compounds are subsequently radiohalogenated via a demetalation reaction. The functional group is suitable for conjugation to protein and can be present or be added subsequent, but most preferably prior, to the radiohalogenation.Also compounds of the formula: R.sub.1 --Ar--R.sub.2, wherein R.sub.1 is either a radiohalogen or any one of the organometallic groups stated above, Ar is aromatic or heteroaromatic ring, and R.sub.2 is a short-chain substituent that does not highly activate the aromatic ring an that bears a functional group suitable for conjugation to protein under conditions that preserve the biological activity of the protein. The radiohalogenated small nolecules are conjugated to proteins such as monoclonal antibodies for use in diagnosis and therapy.
摘要:
A portable aircraft identification system including a platform having at least one pair of wheels and a securable ball hitch assembly, a mast having one end fixed to the platform and being erectable to extend vertically from the platform, a camera and lens system mounted adjacent an upper end of the mast with the camera being positioned so as to aim generally horizontally from the mast, a local area network card connected to the camera and adapted for receiving images from the camera and for transmitting the received images to a remote location, a battery compartment mounted on the platform and containing sufficient batteries to power the camera and network card, a solar charging system mounted on the platform and connected for supplying recharge power to the batteries, and a wind turbine charging system mounted on the platform and connected for supplying recharge power to the batteries.
摘要:
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.
摘要:
The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atoms and three sulfur atoms ("N.sub.2 S.sub.3 "), two nitrogen atoms and four sulfur atoms ("N.sub.2 S.sub.4 "), or three nitrogen atoms and three sulfur atoms ("N.sub.3 S.sub.3 "). Metals, and metal oxides, capable of being chelated by the compounds include those that are radionuclides, such as .sup.99m Tc and .sup.186/188 Re.The targeting agent portion of the chelate-targeting agent conjugates provided includes antibodies, peptides, hormones, enzymes and biological response modifiers. Methods for making the conjugates are provided and encompass the addition of a metal, or metal oxide, to a chelating compound prior to attachment to a targeting agent as well as subsequent to the attachment.Another aspect of the invention provides kits for producing chelate-targeting agent comjugates for radiopharmaceutical use.An additional aspect of the invention provides methods for using the chelate-targeting agent conjugates for diagnostic and therapeutic purposes, such as detection of a target site and delivery of a radionuclide to the site, respectively.
摘要:
The invention provides a mass spectrometer for the analysis of a sample dissolved in a super-critical fluid. The fluid is expanded directly into an ionization chamber without a liquid-gas transition and the sample is ionized by means of a glow discharge established in the chamber. Preferably the electrodes between which the discharge is struck comprise the wall of the ionization chamber and the tube through which the super-critical fluid enters the chamber. The spectrometer is primarily intended for use with a super-critical fluid chromatograph.