摘要:
Disclosed herein are implantable medical devices coated with or comprising bioabsorbable carbon-based nitric oxide-donating polymers that upon exposure to physiological environments donate nitric oxide (NO).
摘要:
Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide, dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要:
Disclosed herein are implantable medical devices comprising controlled release terpolymers and at least one drug releasable from said terpolymers coating. The terpolymers of the present invention are comprised of acrylate and/or vinyl monomers.
摘要:
Disclosed herein are biodegradable modified caprolactone polymers for coating and forming medical devices. The properties of the polymers are fine tuned for optimal performance depending on the medical purpose. Moreover, the polymers are suitable for the controlled in situ release of drugs at the treatment site.
摘要:
Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.
摘要:
Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of drugs from medical devices in vivo are disclosed wherein the porosity of the polymer coatings is varied to control elute rate profiles. Also disclosed are vascular stents and stent grafts with controlled release coatings and related methods for making these coatings.
摘要:
Polymer blends useful as thermoplastic molding resins comprise PC, PETG and sufficient rubber, e.g. nitrile rubber or ethylene-acrylate copolymer rubber, to enhance the moldability of the blend. Preferred blends comprise at least 30% PC, 30% PETG and 5% rubber.
摘要:
Dispersions of core-shell polymers in caprolactam solutions of telechelic polymers capable of being polymerized to form rubber-modified nylon-6 block copolymers having improved impact strength wherein the core-shell polymer comprises a crosslinked elastomer core and a hard thermoplastic polymer shell and wherein the telechelic polymers preformed or formed in situ, are capped with lactam polymerization initiator groups.
摘要:
Dispersions of core-shell polymers in caprolactam wherein the core-shell polymer comprises a crosslinked elastomer core and a hard thermoplastic shell prepared by adding an aqueous dispersion of core-shell polymer to an aqueous solution of caprolactam, stirring the mixture to provide a uniform dispersion and evaporating water from the mixture. Such dispersions can be combined with caprolactam polymerization initiator and caprolactam polymerization catalyst to provide rubber-modified nylon-6 polymers.
摘要:
A molding composition prepared from a blend of: (A) a copolyester of a dicarboxylic acid moiety, such as terephthalic acid or dimethyl terephthalate and a dihydric alcohol moiety, such as ethylene glycol in combination with diethylene glycol or 1,4-cyclohexanedimethanol, and (B) a copolymer prepared from a styrenic monomer and an ethylenically unsaturated nitrile, wherein articles molded from such compositions have improved clarity and toughness.