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38 条记录 (耗时 0.043 秒)

    Process for the preparation of high purity O-substituted hydroxylamine derivatives
    31.
    发明授权
    Process for the preparation of high purity O-substituted hydroxylamine derivatives 失效
    制备高纯度O-取代羟胺衍生物的方法

    公开(公告)号：US5777164A

    公开(公告)日：1998-07-07

    申请号：US837134

    申请日：1997-04-14

    申请人： Neil Warren Boaz

    发明人： Neil Warren Boaz

    IPC分类号： C07C239/20 ,  C07C259/00 ,  C07C259/06 ,  C07C259/10

    CPC分类号： C07C239/20

    摘要： The present invention discloses a method comprising the steps of; a) forming in an aqueous solution a hydroxamic acid from a hydroxylamine free base and anhydride having the formula (RCO).sub.2 O wherein R is H or a substituted or unsubstituted C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.6-10 aryl, or C.sub.4-10 heteroaryl; and b) treating said hydroxamic acid with an alkylating agent in the presence of at least one proton scavenger under conditions sufficient to consume substantially all of said alkylating agent to form an O-substituted hydroxamate. The protection and alkylation are readily effected in water (with no alcohol co-solvent) without the need for phase-transfer catalysis and with little hydrolysis of the alkylating agent.

    摘要翻译： 本发明公开了一种方法，包括以下步骤： a）在水溶液中形成来自无羟胺基的异羟肟酸和具有式（RCO）2 O的酸酐，其中R是H或取代或未取代的C 2-6烷基，C 2-6烯基，C 6-10芳基或C 4 -10个杂芳基; 和b）在至少一种质子清除剂的存在下，在足以消耗基本上全部所述烷基化剂以形成O-取代的异羟肟酸酯的条件下，用烷基化剂处理所述异羟肟酸。 保护和烷基化容易在水（不含醇共溶剂）中进行，而不需要相转移催化剂，并且烷基化剂几乎没有水解。

    Phosphine-phosphoramidite compounds
    36.
    发明授权
    Phosphine-phosphoramidite compounds 有权
    膦 - 亚磷酰胺化合物

    公开(公告)号：US06906212B1

    公开(公告)日：2005-06-14

    申请号：US10876387

    申请日：2004-06-25

    申请人： Neil Warren Boaz

    发明人： Neil Warren Boaz

    IPC分类号： B01J31/18 ,  B01J31/22 ,  C07C51/36 ,  C07C67/303 ,  C07F9/24 ,  C07F9/6571 ,  C07F17/00 ,  C07F17/02 ,  B01J31/00 ,  C07C5/03

    CPC分类号： C07F17/02 ,  B01J31/187 ,  B01J31/2295 ,  B01J2231/645 ,  B01J2531/822 ,  C07B2200/07 ,  C07C51/36 ,  C07C67/303 ,  C07F9/2458 ,  C07F9/657154 ,  C07F17/00 ,  C07C55/02 ,  C07C69/34

    摘要： Disclosed are novel phosphine-phosphoramidite compounds which may be employed in combination with a catalytically-active metal to effect a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. Also disclosed are a process for the preparation of the phosphine-phosphoramidite compounds, metal complex compounds comprising at least one of the phosphine-phosphoramidite compounds and a catalytically-active metal and hydrogenation processes utilizing the metal complex compounds.

    摘要翻译： 公开了可与催化活性金属组合使用的新型膦 - 亚磷酰胺化合物，以实现多种反应，例如不对称氢化，不对称还原，不对称氢化，不对称烯烃异构化，不对称氢化硅，不对称烯丙基化，不对称共轭加成 ，和不对称有机金属添加剂。 还公开了制备膦 - 亚磷酰胺化合物的方法，包含至少一种膦 - 亚磷酰胺化合物和催化活性金属的金属络合物，以及利用金属络合物的氢化方法。

    Phosphinometallocenylamides as novel ligands for asymmetric catalysis
    38.
    发明授权
    Phosphinometallocenylamides as novel ligands for asymmetric catalysis 有权
    作为不对称催化新配体的膦金属茂基酰胺

    公开(公告)号：US06620954B1

    公开(公告)日：2003-09-16

    申请号：US10105516

    申请日：2002-03-25

    申请人： Neil Warren Boaz

    发明人： Neil Warren Boaz

    IPC分类号： C07F1700

    CPC分类号： B01J31/2404 ,  B01J31/2226 ,  B01J31/2252 ,  B01J31/2295 ,  B01J2231/4205 ,  B01J2531/40 ,  B01J2531/50 ,  B01J2531/60 ,  B01J2531/70 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/825 ,  B01J2531/842 ,  C07F17/00 ,  C07F17/02

    摘要： Disclosed are novel phosphinometallocenylamides that are useful as ligands for asymmetric catalysis. The novel ligands, which are readily modifiable, contain both a phosphine and an amide functionality linked by a metallocene backbone. In addition, the novel compounds are phosphine-amides derived from a phosphine-amine, rather than a phosphine-carboxylic acid. Further, described herein are both processes to make the novel ligands as well as processes that employ such ligands in a catalytically active composition comprising one or more phosphinometallocenylamide compounds in complex association with one or more Group VIb or Group VIII metals to provide chiral products. Further, we describe exemplary catalyst complexes incorporating the novel ligands.

    摘要翻译： 公开了可用作不对称催化配体的新型次膦基金属烯基酰胺。 容易修饰的新配体含有通过茂金属主链连接的膦和酰胺官能团。 此外，新化合物是衍生自膦 - 胺而不是膦 - 羧酸的膦酰胺。 此外，本文描述的是制备新型配体的方法以及在包含一种或多种次金属茂金属酰胺化合物的催化活性组合物中使用这种配体的方法，其与一种或多种VIb族或VIII族金属络合以提供手性产物。 此外，我们描述了掺入新配体的示例性催化剂配合物。