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公开(公告)号：US06676902B2
公开(公告)日：2004-01-13
申请号：US10354300
申请日：2003-01-30
申请人： Robert F. Baugh , Julie S. Johnston , Colleen Lutz
发明人： Robert F. Baugh , Julie S. Johnston , Colleen Lutz
IPC分类号： G01N3386
CPC分类号： G01N33/86
摘要： A method and device for testing a sample of fresh whole blood. In particular the present invention provides a method and device for testing a sample of fresh whole blood to determine whether a patient would benefit from the administration of a blood factor (such as AT III.)
摘要翻译： 用于测试新鲜全血样品的方法和装置。 特别地，本发明提供了一种用于测试新鲜全血样品的方法和装置，以确定患者是否可以从血液因子的给药中获益（例如AT III）
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公开(公告)号：US06555381B2
公开(公告)日：2003-04-29
申请号：US09810740
申请日：2001-03-16
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： A method of determining a contact activator for platelet activation and/or clotting activation is provided, comprising placing a predetermined amount of an anticoagulant in each cell of a multicell test cartridge, placing a predetermined amount of a platelet inactivating agent in each cell, and placing a measured amount of contact activator in each cell, the amount of contact activator in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inactivating agent are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to determine the platelet activation and/or clotting activation effect of the clotting activator.
摘要翻译： 提供了确定血小板激活和/或凝血活化的接触激活剂的方法，包括将预定量的抗凝血剂置于多细胞试验盒的每个细胞中，在每个细胞中放置预定量的血小板失活剂，并将 每个电池中的测量量的接触活化剂，每个电池中的接触活化剂的量不同于每个电池中的量。 将血液样品的等分试样加入到每个细胞中，并将血液样品等分试样，凝血试剂和血小板灭活剂混合。 允许每个细胞样品凝块，并测量每个细胞的凝固时间。 相对凝血时间用于确定凝血激活剂的血小板活化和/或凝血活化作用。
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公开(公告)号：US06555064B2
公开(公告)日：2003-04-29
申请号：US09811216
申请日：2001-03-16
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets using a plunger sensor technique, the apparatus comprising a test cell, and wherein the test cell comprises an anticoagulant, a contact activator, and a predetermined amount of a platelet inactivating agent.
摘要翻译： 提供一种用于使用柱塞传感器技术对含血小板血样的活化凝血时间测试进行活化的装置，所述装置包括测试电池，并且其中所述测试电池包括抗凝血剂，接触激活剂和预定量的 血小板灭活剂。
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公开(公告)号：US06468287B1
公开(公告)日：2002-10-22
申请号：US09308414
申请日：1998-10-29
申请人： Robert F. Baugh
发明人： Robert F. Baugh
IPC分类号： A61B500
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150427 , A61B5/150511 , A61B5/150755 , A61B5/15105
摘要： A piercing instrument (12) for obtaining a non-activated drop of blood (B) by capillary puncture is formed by depositing a coating agent (20) on the exterior surface of the piercing instrument (12). The coating agent comprises compounds that inhibit the activation of blood.
摘要翻译： 通过在穿刺器具（12）的外表面上沉积涂覆剂（20），形成用于通过毛细管穿刺获得未激活的血液滴（B）的穿刺器具（12）。 包衣剂包括抑制血液活化的化合物。
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35.发明授权Gas flow coagulation test cartridge having movable member establishing communication between reagent and reaction chambers 失效气流凝固测试盒，其具有在试剂和反应室之间建立连通的可动构件
公开(公告)号：US4533519A
公开(公告)日：1985-08-06
申请号：US515914
申请日：1983-07-20
申请人： Robert F. Baugh , Walter J. Braun , Daniel Cooper
发明人： Robert F. Baugh , Walter J. Braun , Daniel Cooper
CPC分类号： G01N33/4905 , B01L3/502 , A61B5/1455 , B01L2200/16 , B01L2300/047 , B01L2300/069 , B01L2300/0832 , B01L2300/0851 , B01L2300/123 , B01L2400/0481 , B01L2400/0633
摘要： A gas flow cartridge in which to conduct a coagulation-related test uses an elongated pin member movably positioned within a communication opening which separates a reagent chamber from a reaction chamber. A first portion of the pin member has an operative configuration for sealing the communication opening when the first portion is positioned in the communication opening. A second longitudinally displaced portion of the pin member opens the communication opening to further communication therethrough upon longitudinal movement of the pin member. At the commencement of an analytical test, a plug member is moved upwardly to contact the pin member and move the first portion out of the communication opening and the second portion into the communication opening. The upward movement of the lower plug member forces the contents of the reagent chamber through the opened communication opening and into the reaction chamber. A pointed needle-like member pierces a membrane of the lower plug member and injects gas into the cartridge. The gas also flows through the opened communication opening.
摘要翻译： 用于进行凝固相关试验的气体流动药筒使用可移动地定位在将反应室与反应室分离的连通开口内的细长销构件。 销构件的第一部分具有用于当第一部分位于连通开口中时密封连通开口的可操作构造。 销构件的第二纵向位移部分打开连通开口，以在销构件的纵向运动时进一步连通。 在分析测试开始时，插头构件向上移动以接触销构件并将第一部分移出连通开口和第二部分进入连通开口。 下塞件的向上运动迫使试剂室的内容物通过打开的连通开口进入反应室。 尖头的针状部件刺穿下塞子部件的膜并将气体注入到盒中。 气体也流过打开的通气开口。
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