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公开(公告)号：US07838039B2
公开(公告)日：2010-11-23
申请号：US11044984
申请日：2005-01-27
IPC分类号： A61K35/16
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： Provided are methods of applying biological compositions, that is, autologous bioadhesive sealant compositions containing one or more biological agents, to an individual, wherein all the blood components used in preparing the composition are derived from the patient who is to receive the biological composition. In one embodiment, the method comprises obtaining a whole blood sample from an individual; forming an inactive platelet rich plasma from the whole blood sample; mixing a biological agent into the inactive platelet rich plasma; obtaining thrombin from the whole blood sample; mixing the thrombin into the inactive platelet rich plasma to form a biological composition; and applying the biological composition to the individual.
摘要翻译： 提供了将生物组合物，即含有一种或多种生物制剂的自体生物粘附密封剂组合物施用于个体的方法，其中用于制备组合物的所有血液成分来源于接受生物组合物的患者。 在一个实施方案中，该方法包括从个体获得全血样品; 从全血样品中形成无活性血小板富集血浆; 将生物试剂混合到无活性富血小板血浆中; 从全血样品中获得凝血酶; 将凝血酶混合到无活性血小板富集血浆中以形成生物组合物; 并将生物组合物应用于个体。
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公开(公告)号：US06555066B2
公开(公告)日：2003-04-29
申请号：US09810747
申请日：2001-03-16
IPC分类号： G01N3316
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus for performing a platelet inhibition test on a sample of blood is provided, comprising a plurality of test cells, the cells being adapted for receiving an aliquot portion of the sample, wherein each of the cells comprises an anticoagulant and a clotting activator, and wherein at least one of the cells further comprises a platelet inactivating agent, wherein a clotting time is determined for each of the aliquot portions, and wherein a relative clotting time for each of the aliquot portions comprising the platelet inhibitor is determined as compared to a reference clotting time for a cell containing no platelet inhibitor, wherein the relative clotting times for the cells are determinative of the platelet inhibition of the sample.
摘要翻译： 提供了一种用于对血液样品进行血小板抑制试验的装置，包括多个测试细胞，所述细胞适于接收样品的等分试样部分，其中每个细胞包含抗凝血剂和凝血活化剂，以及 其中所述细胞中的至少一个还包含血小板失活剂，其中为每个等分试样部分确定凝血时间，并且其中与参考物相比确定包含血小板抑制剂的每个等分试样部分的相对凝血时间 不含血小板抑制剂的细胞的凝血时间，其中细胞的相对凝血时间决定了样品的血小板抑制。
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公开(公告)号：US06232127B1
公开(公告)日：2001-05-15
申请号：US09330545
申请日：1999-06-11
IPC分类号： G01N3386
CPC分类号： G01N33/4905 , G01N33/86 , G01N2400/40 , G01N2405/04 , Y10T436/10 , Y10T436/107497 , Y10T436/108331
摘要： An improved apparatus and method for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells includes a platelet function restoration agent, an anticoagulant agent, and a clotting reagent. At least one of the cells also includes a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method includes the steps of combining a platelet function restoration agent, an anticoagulant agent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by adding a clotting reagent to the test mixture at the start of the activated clotting time test, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于评估血液样品的血小板功能的改进的装置和方法。 该装置包括多个测试单元。 每个细胞包括血小板功能恢复剂，抗凝血剂和凝血试剂。 至少一个细胞还包括血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括将血小板功能恢复剂，抗凝血剂，血小板活化剂和待测试血液样品组合以形成测试混合物的步骤。 在激活的凝血时间试验开始时，通过向试验混合物中加入凝血试剂来激活样品的血小板，并且在检测到试验混合物的性质的预定变化后终止活化的凝固时间试验。 根据经过的时间计算血液样品的活化凝血时间。
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公开(公告)号：US5807471A
公开(公告)日：1998-09-15
申请号：US640274
申请日：1996-04-30
申请人： Michael Dror , Robert F. Baugh , Peter Ross Schaad
发明人： Michael Dror , Robert F. Baugh , Peter Ross Schaad
CPC分类号： G01N27/40 , Y10S435/817
摘要： A ion selective electrode is formed by an electrode having a first membrane with a diffusion rate selective to heparin or other polyions, and a selective polymeric coating thereon having a polyion diffusion rate lower than the polyion diffusion rate of the first membrane. The electrode is sensitive to solutions containing low polyion concentrations such as low heparin concentrations.
摘要翻译： 离子选择电极由具有对肝素或其它聚阴离子选择性扩散速率的第一膜的电极和其上具有低于第一膜的聚离子扩散速率的聚离子扩散速率的选择性聚合物涂层形成。 电极对含有低聚离子浓度如低肝素浓度的溶液敏感。
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公开(公告)号：US06830762B2
公开(公告)日：2004-12-14
申请号：US10173839
申请日：2002-06-18
IPC分类号： A61K3516
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. In one embodiment, the platelet rich plasma is divided into two portions. In phase one, a compound that reverses the effect of the anticoagulant is added to the first portion and a clot is allowed to form. The clot is then triturated, and the resulting serum containing autologous thrombin is collected. In phase two, the serum obtained from phase one is mixed with the second portion of the platelet rich plasma to form the bioadhesive sealant of the present invention.
摘要翻译： 本发明涉及通过两相方法制备的自体生物粘附密封剂组合物或纤维蛋白胶，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 通过离心一定数量的抗凝血全血形成血小板富血浆和不血小板血浆。 在一个实施方案中，富血小板血浆被分成两部分。 在第一阶段中，将反转抗凝血剂作用的化合物加入第一部分，并形成凝块。 然后将凝块研磨，收集所得到的含有自体凝血酶的血清。 在第二阶段中，将从第一阶段获得的血清与富含血小板的血浆的第二部分混合以形成本发明的生物粘附密封剂。
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公开(公告)号：US06541262B1
公开(公告)日：2003-04-01
申请号：US09560470
申请日：2000-04-28
IPC分类号： G01N3386
CPC分类号： G01N33/86
摘要： A method and device for testing a sample of fresh whole blood. In particular the present invention provides a method and device for testing a sample of fresh whole blood to determine whether a patient would benefit from the administration of a blood factor (such as AT III.)
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公开(公告)号：US06472161B1
公开(公告)日：2002-10-29
申请号：US08583761
申请日：1996-01-11
申请人： Robert F. Baugh
发明人： Robert F. Baugh
IPC分类号： C12Q156
CPC分类号： G01N33/86
摘要： Blood is tested for clot lysis conditions such as natural lytic capabilities, the effect of previously administered thrombolytic and anti-thrombolytic agents, and dose responses thereto, by forming a clot in a sample of blood, lysing the clot, and measuring the elapsed time period from initial clot formation to clot lysis, all while continuously evaluating the blood sample. Thrombolytic agents include streptokinase, urokinase and recombinant tissue plasminogen activator. Plasmin and plasminogen activator inhibitors, clot activating agents (e.g. kaolin), and agents to deactivate anticoagulants (e.g. heparinase) may also be used as reagents during testing.
摘要翻译： 通过在血液样品中形成凝块，溶解凝块并测量经过的时间段，测试血液中的凝块溶解条件，例如天然裂解能力，先前施用的溶栓剂和抗溶栓剂的作用及其剂量反应 从初始凝块形成到凝块溶解，同时连续评估血液样品。 溶血剂包括链激酶，尿激酶和重组组织纤溶酶原激活物。 血浆纤维蛋白溶酶原激活物抑制剂，凝块活化剂（例如高岭土）和使抗凝剂（例如肝素酶）失活的试剂也可以在测试期间用作试剂。
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8.发明授权Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique 失效用于执行不依赖肝素的高灵敏度血小板功能评估技术的装置
公开(公告)号：US6010911A
公开(公告)日：2000-01-04
申请号：US847152
申请日：1997-04-30
CPC分类号： G01N33/86 , G01N2333/988 , G01N2400/40 , G01N2800/52 , Y10T436/101666 , Y10T436/108331
摘要： An apparatus and method for performing activated clotting time tests, including their use for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells comprises a heparin-inactivating agent, an anticoagulant agent, and a clotting reagent. At least one of the test cells further comprises a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method comprises the steps of combining a heparin-inactivating agent, an anticoagulant agent, a clotting reagent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by agitating the test mixture, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于进行活化凝血时间测试的装置和方法，包括其用于评估血液样品的血小板功能性的用途。 该装置包括多个测试单元。 每个细胞包含肝素灭活剂，抗凝血剂和凝血试剂。 至少一个测试细胞还包含血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括以下步骤：将肝素灭活剂，抗凝血剂，凝血试剂，血小板活化剂和待测血液样品混合以形成试验混合物。 通过搅拌测试混合物来激活样品的血小板，并且在检测到测试混合物的性质的预定变化后终止活化的凝血时间测试。 根据经过的时间计算血液样品的活化凝血时间。
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公开(公告)号：US5674236A
公开(公告)日：1997-10-07
申请号：US640276
申请日：1996-04-30
申请人： Robert F. Baugh
发明人： Robert F. Baugh
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150427 , A61B5/150511 , A61B5/150755 , A61B5/15105
摘要： A lancet for obtaining a drop of blood by capillary puncture is formed by a needle having a coating thereon of a composition which precludes contact clotting activation of the blood sample.
摘要翻译： 通过毛细管穿刺获得一滴血液的刺血针通过具有防止血液样品的凝血活化的组合物的组合物的针形成。
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公开(公告)号：US06761856B2
公开(公告)日：2004-07-13
申请号：US10410003
申请日：2003-04-09
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets, the apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.
摘要翻译： 提供了一种用于对含有血小板的样品进行活化的凝血时间测试的装置，所述装置包括多个测试细胞，所述细胞适于接收所述样品的等分部分，其中每个所述细胞包含抗凝血剂和 血小板灭活剂，并且其中所述细胞中的至少一个还包含凝血活化剂，其中确定每个所述等分部分的凝血时间，并且其中确定包含凝血激活剂的每个所述等分部分的相对凝血时间 与所述至少一种不含凝血活化剂的细胞的参考凝血时间相比，其中所述细胞中的所述相对凝血时间决定所述凝血活化剂的凝血活化。
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