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31.发明授权Substituted 2-(2,6-dioxopiperidin-3-yl)- phthalimides and 1-oxoisoindolines and method of reducing TNF&agr; levels 有权取代的2-（2,6-二氧代哌啶-3-基） - 邻苯二甲酰亚胺和1-氧代异吲哚啉和降低TNFalpha水平的方法公开(公告)号：US06395754B1
公开(公告)日：2002-05-28
申请号：US09445002
申请日：2000-02-22
IPC分类号： A61K31445
CPC分类号： C07D401/04
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.
摘要翻译： 取代的2-（2,6-二氧代哌啶-3-基） - 邻苯二甲酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低哺乳动物TNFalpha的含量。 典型的实施方案是1-氧代-2-（2,6-二氧代-3-甲基哌啶-3-基）-4,5,6,7-四氟异吲哚啉。
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公开(公告)号：US5908850A
公开(公告)日：1999-06-01
申请号：US827230
申请日：1997-04-02
IPC分类号： A61K31/4458 , A61K31/445
CPC分类号： A61K31/4458
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
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33.发明授权Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNF.alpha. levels 失效四取代的2-（2,6-二氧代哌啶-3-基）-1-氧代异吲哚啉和降低TNFα水平的方法
公开(公告)号：US5798368A
公开(公告)日：1998-08-25
申请号：US701494
申请日：1996-08-22
IPC分类号： C07D401/04 , A61K31/44
CPC分类号： C07D401/04
摘要： Tetrasubstituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.
摘要翻译： 四取代的1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低哺乳动物的TNFα水平。 典型的实施方案是1-氧代-2-（2,6-二氧代哌啶-3-基）-4,5,6,7-四氟异吲哚啉。
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34.发明授权Method of reducing TNF.alpha. levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines 失效用氨基取代的2-（2,6-二氧代哌啶-3-基）-1-氧代和1,3-二氧代异吲哚啉降低TNFα水平的方法
公开(公告)号：US5635517A
公开(公告)日：1997-06-03
申请号：US690258
申请日：1996-07-24
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04
摘要： 1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines substituted with amino in the benzo ring reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline.
摘要翻译： 苯并环中被氨基取代的1-氧代-1,4-二氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低了哺乳动物的TNFα水平。 典型的实施方案是1,3-二氧代-2-（2,6-二氧代哌啶-3-基）-5-氨基异二氢吲哚。
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公开(公告)号：US5166060A
公开(公告)日：1992-11-24
申请号：US332339
申请日：1989-03-31
IPC分类号： C12P17/12 , C07D213/80 , C07D213/803 , C07D215/54 , C07D215/56 , C12N9/02 , C12N15/53 , C12P7/44 , C12R1/38
CPC分类号： C07D213/80 , C12N9/0069 , C12P7/44 , C12Y113/11014 , Y10S435/877
摘要： Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation.
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36.发明授权
公开(公告)号：US4950606A
公开(公告)日：1990-08-21
申请号：US369723
申请日：1989-06-22
IPC分类号： C07C209/00 , C12N9/10 , C12P7/26 , C12P41/00
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chrially substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
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公开(公告)号：US4652527A
公开(公告)日：1987-03-24
申请号：US659199
申请日：1984-10-09
申请人： David I. Stirling
发明人： David I. Stirling
CPC分类号： C12N1/32 , C12N1/20 , Y10S435/804
摘要： This invention provides a process for single cell protein production which involves the culturing of Methylophilus methylotrophus microorganisms by facultative growth on glucose as a carbon and energy source.
摘要翻译： 本发明提供了一种单细胞蛋白质生产的方法，其涉及通过在作为碳和能量来源的葡萄糖上的兼性生长来培养甲基嗜麦芽孢杆菌微生物。
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38.发明申请Substituted 2-(2,6-Dioxopiperidin-3-yl)-phthalimides and 1-Oxoisoindolines and Method of Reducing TNFalpha Levels 审中-公开取代的2-（2,6-二氧代哌啶-3-基） - 邻苯二甲酰亚胺和1-氧代异吲哚啉和减少TNFα水平的方法公开(公告)号：US20130030021A1
公开(公告)日：2013-01-31
申请号：US13622314
申请日：2012-09-18
IPC分类号： A61K31/454 , A61P43/00 , C07D401/04
CPC分类号： C07D401/04 , A61K31/454
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.
摘要翻译： 公开了取代的2-（2,6-二氧代哌啶-3-基）邻苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉。 该化合物可用于例如降低哺乳动物中TNFα的水平。
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39.发明授权Pharmaceutical compositions of 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-amino isoindoline 有权1,3-二氧代-2-（2,6-二氧代哌啶-3-基）-4-氨基异吲哚啉的药物组合物公开(公告)号：US08158653B2
公开(公告)日：2012-04-17
申请号：US11401862
申请日：2006-04-12
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04 , A61K31/454
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.
摘要翻译： 公开了取代的2-（2,6-二氧代哌啶-3-基）邻苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉。 该化合物可用于例如降低哺乳动物中TNFα的水平。
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40.发明授权Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines 失效取代的2-（2,6-二氧代哌啶-3-基） - 邻苯二甲酰亚胺和1-氧代异吲哚啉公开(公告)号：US07709502B2
公开(公告)日：2010-05-04
申请号：US11401858
申请日：2006-04-12
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04 , A61K31/454
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.
摘要翻译： 公开了取代的2-（2,6-二氧代哌啶-3-基）邻苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉。 该化合物可用于例如降低哺乳动物中TNFα的水平。
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