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63 条记录 (耗时 0.028 秒)

    Sustained delivery of polyionic bioactive agents
    31.
    发明授权
    Sustained delivery of polyionic bioactive agents 失效
    持续输送聚离子生物活性剂

    公开(公告)号：US06395029B1

    公开(公告)日：2002-05-28

    申请号：US09234011

    申请日：1999-01-19

    申请人： Robert J. Levy

    发明人： Robert J. Levy

    IPC分类号： A61F200

    CPC分类号： B82Y5/00 ,  A61F2/82 ,  A61F2250/0098 ,  A61K47/6455 ,  A61K47/6937 ,  A61K48/00 ,  A61L17/145 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606

    摘要： The invention relates to compositions and methods for delivering a polyionic bioactive composition such as a nucleic acid to a tissue of an animal. The compositions of the invention include compositions which comprise a matrix comprising the polyionic bioactive agent and wherein at least most of the polyionic bioactive agent at the exterior portion of the matrix is present in a condensed form. The invention also includes methods of making such compositions, including particles, devices, bulk materials, and other objects which comprise, consist of, or are coated with such compositions. Methods of delivering a polyionic bioactive agent to an animal tissue are also described. The invention further includes a method of storing a nucleic acid.

    摘要翻译： 本发明涉及用于将聚离子生物活性组合物例如核酸递送至动物组织的组合物和方法。 本发明的组合物包括包含基质的组合物，所述基质包含聚离子生物活性剂，并且其中基质外部部分的至少大部分聚离子生物活性剂以浓缩形式存在。 本发明还包括制造这样的组合物的方法，包括颗粒，装置，散装材料以及其它包含这些组合物的组合物，或由这些组合物涂覆的物体。 还描述了将聚离子生物活性剂递送到动物组织的方法。 本发明还包括存储核酸的方法。

    System for controlled release of antiarrhythmic agents
    32.
    发明授权
    System for controlled release of antiarrhythmic agents 失效
    用于控制释放抗心律失常药物的系统

    公开(公告)号：US5387419A

    公开(公告)日：1995-02-07

    申请号：US37810

    申请日：1993-03-26

    申请人： Robert J. Levy ,  Amnon Sintov

    发明人： Robert J. Levy ,  Amnon Sintov

    IPC分类号： A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/0024 ,  A61K9/7007 ,  Y10S514/821

    摘要： A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl.sub.3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.

    摘要翻译： 用于受控释放，特定地点递送治疗剂，特别是心肌药物如抗心律失常剂的系统包括具有用于直接置于心外膜的并入治疗剂的生物相容性聚合物基质。 有利地，剂型可以按照所需待处理的物理条件的性质来定制释放特性的方式制造。 在具体的说明性实施方案中，通过独特的方法将利多卡因，抗心律失常抑制剂掺入聚氨酯中，其允许聚合物基质的药物加载量为约5％至40％重量，优选的为约25％至30％ 实施例。 尽管在聚合物基质混合物中存在药物，但新型FeCl 3催化剂使聚氨酯聚合。

    Biodegradable Linkers for Molecular Therapies
    36.
    发明申请
    Biodegradable Linkers for Molecular Therapies 有权
    用于分子疗法的生物可降解接头

    公开(公告)号：US20120141419A1

    公开(公告)日：2012-06-07

    申请号：US13306459

    申请日：2011-11-29

    申请人： Ivan Alferiev ,  Robert J. Levy ,  Ilia Fishbein

    发明人： Ivan Alferiev ,  Robert J. Levy ,  Ilia Fishbein

    IPC分类号： A61K48/00 ,  A61K38/44 ,  A61P9/00 ,  C12N15/861

    CPC分类号： A61K47/6957 ,  A61K47/6901 ,  C12N2799/022

    摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.

    摘要翻译： 用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。 还提供了制备组合物的方法。

    MAGNETICALLY-DRIVEN BIODEGRADABLE GENE DELIVERY NANOPARTICLES FORMULATED WITH SURFACE-ATTACHED POLYCATIONIC COMPLEX
    38.
    发明申请
    MAGNETICALLY-DRIVEN BIODEGRADABLE GENE DELIVERY NANOPARTICLES FORMULATED WITH SURFACE-ATTACHED POLYCATIONIC COMPLEX 审中-公开
    用表面附着的聚合复合物制备的磁性可驱动的可生物降解的基因递送纳米颗粒

    公开(公告)号：US20110076767A1

    公开(公告)日：2011-03-31

    申请号：US12960968

    申请日：2010-12-06

    申请人： Michael Chrony ,  Boris Polyak ,  Ilia Fishbein ,  Ivan Alferiev ,  Robert J. Levy

    发明人： Michael Chrony ,  Boris Polyak ,  Ilia Fishbein ,  Ivan Alferiev ,  Robert J. Levy

    IPC分类号： C12N5/071 ,  H01F1/26

    CPC分类号： A61K9/5146 ,  A61K9/5094 ,  A61K9/5153 ,  A61K47/59 ,  A61K47/6923 ,  A61K47/6929

    摘要： A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.

    摘要翻译： 包括基质形成剂和聚电解质 - 两亲加合物的颗粒，其中聚电解质 - 两亲性加合物与基质形成剂物理连通。 颗粒还包括涂覆的磁场响应剂和生物材料。 提供制造颗粒的方法。 还提供了将生物材料递送到靶细胞或靶组织的方法，包括施用具有基质形成剂的颗粒，聚电解质 - 两亲剂加合物，包被的磁场响应剂和生物材料; 提供与所述靶细胞或所述靶组织相关联的磁性装置; 向颗粒施加磁力; 并通过磁力将粒子引向磁性装置。

    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
    39.
    发明授权
    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same 失效
    在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法

    公开(公告)号：US06900282B2

    公开(公告)日：2005-05-31

    申请号：US10672892

    申请日：2003-09-26

    申请人： Ivan Alferiev ,  Ilia Fishbein ,  Robert J. Levy

    发明人： Ivan Alferiev ,  Ilia Fishbein ,  Robert J. Levy

    IPC分类号： C08G20060101 ,  C08G18/48 ,  C08G18/66 ,  C08G18/83 ,  G01N21/64 ,  C08G18/30

    CPC分类号： C08G18/4854 ,  C08G18/6674 ,  C08G18/834 ,  C08G18/836 ,  C08G18/838

    摘要： A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-RL-(FG)n, wherein n is an integer from 1 to 3, FG is a functional group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, LG is a leaving group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, and RL is an (n+1)-valent organic radical having at least one carbon atom; providing a protected thiol-containing reagent of a formula R—C(O)SH, or a salt thereof, wherein R is a C1 to C6 alkyl group; reacting the multifunctional linker reagent with the urethane amino moiety to form a polyurethane substituted with at least one substituent group of a formula: —RL-(FG)n; reacting the polyurethane with a protected thiol-containing reagent to form the polyurethane derivative.

    摘要翻译： 一种制备聚氨酯衍生物的方法，该方法包括：提供具有氨基甲酸酯氨基部分的聚氨酯，提供下式的多官能接头试剂：（R） - （FG）n / SUB，其中n为1至3的整数，FG为卤素，羧基，磺酸酯或环氧基的官能团，LG为离去基团，其为卤素， 羧基，磺酸酯或环氧基，R L是具有至少一个碳原子的（n + 1）价有机基团; 提供式R-C（O）SH或其盐的受保护的含硫醇的试剂，其中R是C 1至C 6烷基; 使多官能接头试剂与氨基甲酸酯氨基部分反应以形成由至少一个下式的取代基取代的聚氨酯：（R） - （FG）n < 使聚氨酯与被保护的含硫醇的试剂反应以形成聚氨酯衍生物。