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公开(公告)号：US07601700B2
公开(公告)日：2009-10-13
申请号：US12184379
申请日：2008-08-01
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20090082975A1
公开(公告)日：2009-03-26
申请号：US12237330
申请日：2008-09-24
IPC分类号： G01N33/48
摘要： The present invention provides a method of identifying a predictor of antisense oligonucleotide activity by identifying properties of oligonucleotides, evaluating oligonucleotide activity of the oligonucleotides, and correlating oligonucleotide activity with the properties. A high correlation between oligonucleotide activity and a property indicates that the property is a predictor of oligonucleotide activity.
摘要翻译： 本发明提供了通过鉴定寡核苷酸的性质，评价寡核苷酸的寡核苷酸活性以及将寡核苷酸活性与性质相关联来鉴定反义寡核苷酸活性的预测物的方法。 寡核苷酸活性与性质之间的高相关性表明该性质是寡核苷酸活性的预测因子。
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公开(公告)号：US07425544B2
公开(公告)日：2008-09-16
申请号：US10571339
申请日：2004-09-17
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20070238687A1
公开(公告)日：2007-10-11
申请号：US11697262
申请日：2007-04-05
申请人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
发明人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
IPC分类号： A61K31/711 , A61K31/7105 , A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
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公开(公告)号：US20070185044A1
公开(公告)日：2007-08-09
申请号：US10592435
申请日：2005-03-08
申请人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
发明人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/15001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。
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公开(公告)号：US20070054869A1
公开(公告)日：2007-03-08
申请号：US11449446
申请日：2006-06-07
申请人： C. Bennett , Kenneth Dobie , Don Cleveland , Richard Smith
发明人： C. Bennett , Kenneth Dobie , Don Cleveland , Richard Smith
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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37.发明申请公开(公告)号：US20060234972A1
公开(公告)日：2006-10-19
申请号：US11390894
申请日：2006-03-27
申请人： James Karras , Kenneth Dobie
发明人： James Karras , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6512
CPC分类号： C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.
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公开(公告)号：US20050282760A1
公开(公告)日：2005-12-22
申请号：US10515538
申请日：2003-06-12
申请人： Lex Cowsert , Kenneth Dobie
发明人： Lex Cowsert , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PTPN12. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPN12. Methods of using these compounds for modulation of PTPN12 expression and for treatment of diseases associated with expression of PTPN12 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节PTPN12的表达。 组合物包含靶向编码PTPN12的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTPN12表达和治疗与PTPN12表达相关的疾病的方法。
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公开(公告)号：US20050227939A1
公开(公告)日：2005-10-13
申请号：US11036095
申请日：2005-01-14
申请人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21034 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节激肽释放酶6的表达。该组合物包含靶向编码激肽释放酶的核酸的寡核苷酸。6.使用这些化合物调节激肽释放酶6表达并用于诊断和治疗与表达相关的疾病的方法 提供激肽释放酶6。
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公开(公告)号：US20050215506A1
公开(公告)日：2005-09-29
申请号：US11071788
申请日：2005-03-02
申请人： C. Bennett , Thomas Condon , Susan Freier , James Karras , Susan Fitch , Ravi Jain , Kenneth Dobie
发明人： C. Bennett , Thomas Condon , Susan Freier , James Karras , Susan Fitch , Ravi Jain , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
CPC分类号： C07H21/02 , A61K38/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/18001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of tyrosinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding tyrosinase. Methods of using these compounds for modulation of tyrosinase expression and for diagnosis and treatment of disease associated with expression of tyrosinase are provided
摘要翻译： 提供化合物，组合物和方法用于调节酪氨酸酶的表达。 组合物包含靶向编码酪氨酸酶的核酸的寡核苷酸。 提供了使用这些化合物调节酪氨酸酶表达和诊断和治疗与酪氨酸酶表达相关的疾病的方法
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