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    Sertraline hydrochloride polymorphs
    31.
    发明申请
    Sertraline hydrochloride polymorphs 审中-公开
    舍曲林盐酸多晶型物

    公开(公告)号：US20080176949A1

    公开(公告)日：2008-07-24

    申请号：US12077993

    申请日：2008-03-21

    申请人： Eduard Schwartz ,  Tamar Nidam ,  Anita Liberman ,  Marioara Mendelovici ,  Judith Aronhime ,  Claude Singer ,  Evgeni Valdman

    发明人： Eduard Schwartz ,  Tamar Nidam ,  Anita Liberman ,  Marioara Mendelovici ,  Judith Aronhime ,  Claude Singer ,  Evgeni Valdman

    IPC分类号： A61K31/135 ,  A61P43/00 ,  C07C211/33

    CPC分类号： C07C209/84 ,  A61K31/135 ,  C07C211/42 ,  C07C2602/10

    摘要： The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.

    摘要翻译： 本发明涉及舍曲林盐酸盐的形式II，III，V，VI，VII，VIII，IX和X及其制备方法。 根据本发明，盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。 舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。 舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。 盐酸舍曲林形式VII可以通过将舍曲林氯化物多晶型V悬浮在水中，然后过滤来制备。 盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。 舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中，然后过滤来制备。

    Preparation method of azithromycin hydrates
    39.
    发明授权
    Preparation method of azithromycin hydrates 失效
    阿奇霉素水合物的制备方法

    公开(公告)号：US06586576B2

    公开(公告)日：2003-07-01

    申请号：US09755829

    申请日：2001-01-04

    申请人： Judith Aronhime ,  Claude Singer ,  Michael Pesachovich

    发明人： Judith Aronhime ,  Claude Singer ,  Michael Pesachovich

    IPC分类号： C07H1708

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： This invention relates to a method for preparing azithromycin dihydrate from crude azithromycin by the gradual crystallization of azithromycin from acetone by the addition of a minimal amount of water to effect crystal formation is disclosed. This invention also relates to a method of making azithromycin from desmethyl-azithromycin by dissolving desmethyl-azithromycin in acetone, adding activated carbon, adding formaldehyde, adding formic acid; refluxing the desmethyl-azithromycin acetone solution, adding sodium hydroxide to induce precipitation of azithromycin, and isolating azithromycin.

    摘要翻译： 本发明涉及从阿奇霉素制备阿奇霉素二水合物的方法，其通过加入最少量的水来实现晶体形成，由阿奇霉素从丙酮中逐渐结晶。 本发明还涉及通过将去甲基 - 阿奇霉素溶解在丙酮中，加入活性炭，加入甲醛，加入甲酸，由去甲基 - 阿奇霉素制备阿奇霉素的方法。 回流脱甲基阿奇霉素丙酮溶液，加入氢氧化钠诱导阿奇霉素沉淀，分离阿奇霉素。

    Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
    40.
    发明授权
    Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol 失效
    含有超过500ppm，高达约3,000ppm水和超过200ppm，高达约5,000ppm酒精的稳定的索非唑

    公开(公告)号：US07683080B2

    公开(公告)日：2010-03-23

    申请号：US10717325

    申请日：2003-11-18

    申请人： Anita Liberman ,  Claude Singer ,  Irena Veinberg

    发明人： Anita Liberman ,  Claude Singer ,  Irena Veinberg

    IPC分类号： A61K31/4439 ,  C07D401/12

    CPC分类号： C07D401/12

    摘要： The present invention provides a stable 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole (lansoprazole) comprising either greater than 500 ppm and not more than about 3,000 ppm water or greater than 200 ppm and not more than about 5,000 ppm alcohol, or both. The present invention provides a method of preparing a stable lansoprozole as well as a pharmaceutical composition containing same. The present invention further provides a method of purifying lansoprazole that is substantially free of sulfone and sulfide derivatives.

    摘要翻译： 本发明提供包含大于500ppm且不大于约3,000ppm水或大于200ppm且不超过约5,000ppm的醇的稳定的2-（2-吡啶基甲基）亚磺酰基-1H-苯并咪唑（兰索拉唑），或 都。 本发明提供了制备稳定的兰索佐唑以及含有它的药物组合物的方法。 本发明还提供了一种纯化基本上不含砜和硫化物衍生物的兰索拉唑的方法。