公开(公告)号：US09283025B2

公开(公告)日：2016-03-15

申请号：US12095701

申请日：2006-12-06

申请人： Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao ,  Chou Thao

发明人： Saurav Paul ,  Kedar Ravindra Belhe ,  Hong Cao ,  Chou Thao

IPC分类号： A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61B18/00

CPC分类号： A61B18/1206 ,  A61B18/1492 ,  A61B34/20 ,  A61B2018/00303 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00702 ,  A61B2018/0075 ,  A61B2018/00755 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2090/064 ,  A61B2090/065

摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

公开(公告)号：US20130261491A1

公开(公告)日：2013-10-03

申请号：US13777556

申请日：2013-02-26

申请人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

IPC分类号： A61B5/01

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

公开(公告)号：US08486062B2

公开(公告)日：2013-07-16

申请号：US11550302

申请日：2006-10-17

申请人： Kedar Ravindra Belhe ,  Saurav Paul ,  Hong Cao ,  John Avi Roop

发明人： Kedar Ravindra Belhe ,  Saurav Paul ,  Hong Cao ,  John Avi Roop

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00351 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2018/1497

摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.

摘要翻译： 弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。 导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。 治疗心房扑动的方法采用弯曲消融导管。

公开(公告)号：US20130172874A1

公开(公告)日：2013-07-04

申请号：US13340127

申请日：2011-12-29

申请人： Saurav Paul ,  Riki Chou Thao

发明人： Saurav Paul ,  Riki Chou Thao

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00875 ,  A61B2018/1407 ,  A61B2090/065

摘要： An ablation device for creating linear lesions comprises a flexible support structure defining at least a partial curve; and an electrode disposed on the flexible support structure. The electrode comprises a pressure sensitive conductive composite that is configured for electrical communication with an electrical conductor and a flexible conductive outer covering that covers at least a portion of the pressure sensitive conductive composite. Electrical resistance of the pressure sensitive conductive composite varies inversely in proportion to pressure that is applied to the pressure sensitive conductive composite. Methods of creating linear lesions are also provided.

摘要翻译： 用于产生线性损伤的消融装置包括限定至少部分曲线的柔性支撑结构; 以及设置在柔性支撑结构上的电极。 电极包括压敏导电复合材料，其被配置为与电导体电连通，并且柔性导电外覆层覆盖至少一部分压敏导电复合材料。 压敏导电复合材料的电阻与施加在压敏导电复合材料上的压力成反比。 还提供了创建线性损伤的方法。

公开(公告)号：US08449537B2

公开(公告)日：2013-05-28

申请号：US11618692

申请日：2006-12-29

申请人： Hong Cao ,  Xiaoping Guo ,  Isaac Shai ,  Michael Yang ,  Kedar Ravindra Belhe ,  Saurav Paul ,  Chou Thao

发明人： Hong Cao ,  Xiaoping Guo ,  Isaac Shai ,  Michael Yang ,  Kedar Ravindra Belhe ,  Saurav Paul ,  Chou Thao

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00005 ,  A61B2018/00357

摘要： An ablation catheter is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode is connected relative to the distal end of the catheter for providing ablation energy to patient tissue. A heat sink is provided that is in thermal contact with the ablation electrode. The heat sink, in addition to being in thermal contact with the ablation electrode, is electrically isolated from the ablation electrode. This allows the heat sink to conduct heat away from the ablation electrode without dissipating electrical energy from the electrode. In this regard, the heat sink may prevent build-up of excess heat within the electrode that may result in blood coagulation and/or tissue charring.

摘要翻译： 提供消融导管以消融患者的内部组织。 该导管包括适于相对于其中的期望位置（例如，在心脏内）插入体腔内的远端。 消融电极相对于导管的远端连接，以向患者组织提供消融能量。 提供与消融电极热接触的散热器。 除了与消融电极热接触之外，散热器与消融电极电隔离。 这允许散热器将热量从消融电极导出，而不会从电极中消耗电能。 在这方面，散热器可以防止在电极内积聚多余的热量，从而导致血液凝固和/或组织烧焦。

公开(公告)号：US08388549B2

公开(公告)日：2013-03-05

申请号：US12751946

申请日：2010-03-31

申请人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

IPC分类号： A61B5/00

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

公开(公告)号：US20110270191A1

公开(公告)日：2011-11-03

申请号：US13142957

申请日：2009-12-23

申请人： Saurav Paul ,  Todd R. Stangenes ,  Reer R. Heimbecher

发明人： Saurav Paul ,  Todd R. Stangenes ,  Reer R. Heimbecher

IPC分类号： A61B17/34

CPC分类号： A61B17/3403 ,  A61B17/3478 ,  A61B17/3498 ,  A61B2017/00243 ,  A61B2017/3405 ,  A61M29/00

摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.

摘要翻译： 提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。 针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置 扩张器（12,112）。 针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

公开(公告)号：US20110022045A1

公开(公告)日：2011-01-27

申请号：US12893707

申请日：2010-09-29

申请人： Hong Cao ,  Riki Thao ,  Saurav Paul

发明人： Hong Cao ,  Riki Thao ,  Saurav Paul

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2090/065

摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. In an exemplary embodiment the assembly includes a catheter shaft and a trio of pressure sensitive capacitive members each of whose electrical resistance varies with a pressure vector applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive capacitive members. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive capacitors.

摘要翻译： 公开了一种用于评估导管组件和组织之间的接触的导管组件。 在示例性实施例中，组件包括导管轴和三个压敏电容构件，每个电阻构件的电阻随着施加到导管组件的压力矢量而变化。 组件还包括至少一个测量端子，以允许测量压敏电容构件的电特性的变化。 组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。 组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。 可选地，组件可以包括导电外层。 还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏电容器有关的制造方法。

公开(公告)号：US07824377B2

公开(公告)日：2010-11-02

申请号：US11962512

申请日：2007-12-21

申请人： James V. Kauphusman ,  Israel A. Byrd ,  Saurav Paul

发明人： James V. Kauphusman ,  Israel A. Byrd ,  Saurav Paul

IPC分类号： A61M5/178

CPC分类号： A61M25/04 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2090/065 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0095

摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.

摘要翻译： 公开了用于将导管系统锚定到组织​​的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。 示例性组织锚定导管包括连接到导管手柄的外导管轴。 输送护套设置在外导管轴内，输送护套容纳针。 至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。 组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

公开(公告)号：US20090163916A1

公开(公告)日：2009-06-25

申请号：US11963430

申请日：2007-12-21

申请人： Saurav Paul ,  Hong Cao ,  Chou Thao

发明人： Saurav Paul ,  Hong Cao ,  Chou Thao

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00136 ,  A61B2018/00148 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821

摘要： An electrode for ablation therapy includes a flexible conductive element for conducting electrical energy and a flexible conductive polymer member in electrically conductive contact with the conductive element. A catheter shaft may be coupled to the conductive element and/or the flexible conductive polymer member. The flexible conductive element may be formed as a helical coil, a mesh coating or wrap, or any other suitable form, and may surround (wholly or partially) a flexible electrically insulative, and optionally thermally conductive, member. A heat sink may be thermally coupled to at least one of the flexible conductive polymer member and the flexible electrically insulative member. The flexible electrically insulative member may include a passageway for coolant fluid to cool the electrode during ablation. The passageway may include at least one efflux hole to permit coolant fluid to flow from the passageway, or may define a closed loop.

摘要翻译： 用于消融治疗的电极包括用于传导电能的柔性导电元件和与导电元件导电接触的柔性导电聚合物构件。 导管轴可以联接到导电元件和/或柔性导电聚合物构件。 柔性导电元件可以形成为螺旋线圈，网状涂层或包裹物或任何其它合适的形式，并且可以围绕（全部或部分地）柔性电绝缘和任选地导热的构件。 散热器可以热耦合到柔性导电聚合物构件和柔性电绝缘构件中的至少一个。 柔性电绝缘构件可以包括用于在消融期间冷却电极的冷却剂流体的通道。 通道可以包括至少一个排出孔，以允许冷却剂流体从通道流出，或者可以限定闭环。