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50 条记录 (耗时 0.043 秒)

    Dihydrobenzofuran derivatives, process for the preparing thereof and agents
    31.
    发明授权
    Dihydrobenzofuran derivatives, process for the preparing thereof and agents 失效
    二氢苯并呋喃衍生物，其制备方法和试剂

    公开(公告)号：US07008940B1

    公开(公告)日：2006-03-07

    申请号：US10069314

    申请日：2000-08-18

    申请人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Tetsuya Tsukamoto

    发明人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Tetsuya Tsukamoto

    IPC分类号： A61P9/00 ,  A61P25/00 ,  A61K31/407 ,  A61K31/55 ,  C07D491/48

    CPC分类号： C07D491/04

    摘要： A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein ring A denotes a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, B ring denotes a benzene ring which may be further substituted, C ring denotes a dihydrofuran ring which may be further substituted, and R denotes hydrogen atom or an acyl group.

    摘要翻译： 由式（I）表示的化合物或其盐表现出优异的脂质过氧化抑制活性，可用作抑制脂肪过氧化物产生的试剂，其中环A表示非芳香族5至7元含氮杂环 环可以进一步被取代，B环表示可以被进一步取代的苯环，C环表示可以被进一步取代的二氢呋喃环，R表示氢原子或酰基。

    Benzofuran derivatives, their production and use
    32.
    发明申请
    Benzofuran derivatives, their production and use 失效
    苯并呋喃衍生物，其生产和使用

    公开(公告)号：US20050187238A1

    公开(公告)日：2005-08-25

    申请号：US11081615

    申请日：2005-03-17

    申请人： Shigenori Ohkawa ,  Yasuyoshi Arikawa ,  Kouki Kato ,  Masahiro Okura ,  Masaki Setoh

    发明人： Shigenori Ohkawa ,  Yasuyoshi Arikawa ,  Kouki Kato ,  Masahiro Okura ,  Masaki Setoh

    IPC分类号： A61P25/28 ,  C07D307/79 ,  C07D405/04 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D491/056 ,  C07D491/107 ,  A61K31/4747 ,  C07D493/04

    CPC分类号： C07D307/79 ,  C07D405/04 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06

    摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.

    摘要翻译： 由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或R 1和R 2 可以与相邻的碳原子一起形成3-至8-元的杂环或杂环，W表示（i）由下式表示的基团：其中环B表示5-至 或（ii）由下式表示的基团：其中R 4表示（1）可被芳基取代的脂族烃基，或（2）酰基 含有芳基的基团R 5是氢原子，C 1-6烷基或酰基，条件是当W是Wa时，R“ 当W为Wb时，R 3为氢原子，烃基或杂环基，R 3为C 6-14芳基，或其盐 或其前药具有抑制神经变性等优异的作用以及优异的脑渗透性，并且l 因此可用作神经变性疾病等的预防或治疗药物。

    Tricyclic compound, their production and use
    33.
    发明授权
    Tricyclic compound, their production and use 失效
    三环化合物，其生产和使用

    公开(公告)号：US06417213B2

    公开(公告)日：2002-07-09

    申请号：US09800988

    申请日：2001-03-07

    申请人： Shigenori Ohkawa ,  Masaki Setoh ,  Zen-ichi Terashita

    发明人： Shigenori Ohkawa ,  Masaki Setoh ,  Zen-ichi Terashita

    IPC分类号： A61K31423

    CPC分类号： C07D277/60 ,  C07D277/84 ,  C07D513/04

    摘要： A compound of the formula wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is —S—, —O—, or —N(R2)— (R2 is H or a substituent group), Z is —N═ or —C(R3)═ (R3 is H or a hydrocarbon group), ring A is a benzene ring; ring B is a 5- to 7-membered ring which may be substituted, or a salt thereof is useful for eliciting a prostaglandin I2 receptor agonistic effect.

    摘要翻译： 式R 1的化合物是H或取代基; m为1-3; Ar是可以被取代的芳基; X是可以被取代的具有1-6个原子的键或二价直链基团; Y是-S-，-O-或-N（R2） - （R2是H或取代基），Z是-N =或-C（R3）=（R3是H或烃基），环 A是苯环; 环B是可被取代的5-至7-元环，或其盐可用于引发前列腺素I2受体激动作用。

    Method for treating or preventing sleep disorders
    34.
    发明授权
    Method for treating or preventing sleep disorders 失效
    治疗或预防睡眠障碍的方法

    公开(公告)号：US06348485B1

    公开(公告)日：2002-02-19

    申请号：US09700405

    申请日：2000-11-14

    申请人： Shigenori Ohkawa ,  Masaomi Miyamoto

    发明人： Shigenori Ohkawa ,  Masaomi Miyamoto

    IPC分类号： A61K31415

    CPC分类号： A61K31/435 ,  A61K31/495 ,  A61K31/55 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition for treating or preventing sleep disorders which comprises (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide in combination with at least one active component selected from zolpidem, zopiclone, triazolam and brotizolam.

    摘要翻译： 本发明提供了用于治疗或预防睡眠障碍的药物组合物，其包含（S）-N- [2-（1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基 ）乙基]丙酰胺与至少一种选自唑吡旦，佐匹克隆，三唑仑和brotizolam的活性成分组合。

    Cyclic ether compounds as sodium channel modulators
    35.
    发明授权
    Cyclic ether compounds as sodium channel modulators 失效
    环状醚化合物作为钠通道调节剂

    公开(公告)号：US06172085B2

    公开(公告)日：2001-01-09

    申请号：US09242067

    申请日：1999-02-08

    申请人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    发明人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    IPC分类号： C07D40506

    CPC分类号： C07D405/06 ,  C07D307/81 ,  C07D407/12

    摘要： A compound of the formula: wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.

    摘要翻译： 下式的化合物：其中R1和R2各自表示氢，可被取代的或低级烷基的酰基; R 3，R 4和R 5各自表示可以被取代的低级烷基或可被取代的低级烷氧基，或者R 4和R 5一起代表5-或6-元碳环基; R6代表低级烷基; Ar表示可以被取代的芳基; 环A表示可以被取代的5至8元含氮杂环; X表示可以被取代的低级亚烷基; Y表示碳或氮; Za表示CH2，COCH2，OCH2，SCH2，NHCH2等; Zb表示可以被取代并可以含有O，N或S的键或二价脂族烃基; m表示1〜3的整数，或其盐可用于调制钠通道的药物组合物。

    Diazepinones, their production and use
    36.
    发明授权
    Diazepinones, their production and use 失效
    二氮嗪类，其生产和使用

    公开(公告)号：US5866567A

    公开(公告)日：1999-02-02

    申请号：US666430

    申请日：1996-06-25

    申请人： Shigenori Ohkawa ,  Nobuhiro Fujii ,  Koichi Kato

    发明人： Shigenori Ohkawa ,  Nobuhiro Fujii ,  Koichi Kato

    IPC分类号： C07D401/14 ,  C07D403/06 ,  A61K31/55

    CPC分类号： C07D401/14 ,  C07D403/06

    摘要： A compound of the general formula ##STR1## wherein A represents a benzene ring, B represents a 6-membered hydrocarbon ring; X represents a lower alkylene, carbonyl or sulfonyl; Y represents a bond, oxygen or >N--R.sup.1, R.sup.1 represents H or an alkyl group, R represents H, an aromatic group, or an alkyl group optionally substituted by an aromatic group; m and n each represents 1-3, or a salt thereof has potent GnRH receptor antagonizing activity.

    摘要翻译： PCT No.PCT / JP96 / 01463 Sec。 371日期1996年6月25日第 102（e）日期1996年6月25日PCT提交1996年5月30日PCT公布。 WO96 / 38438 PCT公开号 日期：1996年12月5日通式（I）的化合物其中A表示苯环，B表示6元烃环; X表示低级亚烷基，羰基或磺酰基; Y表示键，氧或> N-R1，R1表示H或烷基，R表示H，芳基或任选被芳基取代的烷基; m和n各自表示1-3，或其盐具有有效的GnRH受体拮抗活性。

    Benzofuran derivatives, their production and use
    40.
    发明授权
    Benzofuran derivatives, their production and use 失效
    苯并呋喃衍生物，其生产和使用

    公开(公告)号：US07101867B2

    公开(公告)日：2006-09-05

    申请号：US10120102

    申请日：2002-04-11

    申请人： Shigenori Ohkawa ,  Yasuyoshi Arikawa ,  Kouki Kato ,  Masahiro Okura ,  Masaki Setoh

    发明人： Shigenori Ohkawa ,  Yasuyoshi Arikawa ,  Kouki Kato ,  Masahiro Okura ,  Masaki Setoh

    IPC分类号： A61K31/33 ,  A61K31/40 ,  C07D405/00 ,  C07D411/00 ,  C07D209/00

    CPC分类号： C07D307/79 ,  C07D405/04 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06

    摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.

    摘要翻译： 由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或R 1和R 2 可以与相邻的碳原子一起形成3-至8-元的杂环或杂环，W表示（i）由下式表示的基团：其中环B表示5-至 或（ii）由下式表示的基团：其中R 4表示（1）可被芳基取代的脂族烃基，或（2）酰基 含有芳基的基团R 5是氢原子，C 1-6烷基或酰基，条件是当W是Wa时，R“ 当W为Wb时，R 3为氢原子，烃基或杂环基，R 3为C 6-14芳基，或其盐 或其前药具有抑制神经变性等优异的作用以及优异的脑渗透性，并且l 因此可用作神经变性疾病等的预防或治疗药物。