公开(公告)号：US07666846B2

公开(公告)日：2010-02-23

申请号：US10550907

申请日：2004-04-02

申请人： Gil Ben-Menachem ,  Joanna Kubler-Kielb ,  Rachel Schneerson ,  John B. Robbins ,  Vince Pozsgay

发明人： Gil Ben-Menachem ,  Joanna Kubler-Kielb ,  Rachel Schneerson ,  John B. Robbins ,  Vince Pozsgay

IPC分类号： A61K31/70 ,  C07J41/00

CPC分类号： A61K39/0225 ,  A61K47/6415 ,  A61K47/643 ,  A61K2039/6037 ,  C07J9/00 ,  C07J17/00 ,  Y02A50/401

摘要： Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.

摘要翻译： 独特的化合物可以通过向受试者施用治疗有效量的糖脂而在受试者中诱导针对博氏疏螺旋体的免疫应答。 这种给药对于预防或治疗受试者中的莱姆病特别有用。 化合物及其治疗上可接受的盐可以配制成药物或免疫原性组合物。

公开(公告)号：US07422755B2

公开(公告)日：2008-09-09

申请号：US11035884

申请日：2005-01-18

申请人： Joanna Kubler-Kielb ,  Rachel Schneerson ,  John B. Robbins

发明人： Joanna Kubler-Kielb ,  Rachel Schneerson ,  John B. Robbins

IPC分类号： A61K45/00 ,  A61K39/00 ,  C12P19/00 ,  C07K1/00 ,  C07K16/00

CPC分类号： A61K39/07 ,  A61K2039/6081 ,  C07K16/1242 ,  C07K16/1271

摘要： The present invention relates, e.g., to a glycoconjugate composition comprising one or more polysaccharide types from a cell wall polysaccharide preparation from B. pumilus Sh 18, or variants thereof. Also disclosed are antibodies generated against the glycoconjugates, and methods of using the glycoconjugates and antibodies. An antimultiorganism vaccine which reacts against at least Haemophilus influenzae type a, Haemophilus influenzae type b, Staphylococcus aureus, and Staphylococcus epidermidis, is disclosed.

摘要翻译： 本发明涉及例如包含一种或多种多糖类型的糖缀合物组合物，所述多糖类型来自微生物短小芽孢杆菌Sh18的细胞壁多糖制剂或其变体。 还公开了针对糖缀合物产生的抗体，以及使用糖缀合物和抗体的方法。 公开了至少对流感嗜血杆菌a型，流感嗜血杆菌b型，金黄色葡萄球菌和表皮葡萄球菌进行反应的抗多元素疫苗。

公开(公告)号：US06685949B1

公开(公告)日：2004-02-03

申请号：US09610034

申请日：2000-07-05

申请人： Xin-Xing Gu ,  John B. Robbins

发明人： Xin-Xing Gu ,  John B. Robbins

IPC分类号： A61K3902

CPC分类号： C12P19/04 ,  A61K39/1045 ,  A61K2039/5555 ,  A61K2039/55572 ,  A61K2039/6037

摘要： A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.

摘要翻译： 包含分离出的脂多糖的莫拉沙氏菌（Branhamella）卡他氏菌共轭疫苗，其中除去了酯化的脂肪酸，产生脱脂脂寡糖（dLOS），或从其中除去脂质A，产生解毒的寡糖（OS） 与免疫原性载体连接。 该疫苗可用于预防由哺乳动物包括人在内的卡他莫拉菌引起的中耳炎和呼吸道感染。

公开(公告)号：US5424224A

公开(公告)日：1995-06-13

申请号：US5713

申请日：1993-01-19

申请人： Franklin L. Allen ,  Eugene C. Davis ,  Lawrence D. Dyer ,  Jerry B. Medders ,  Vikki S. Simpson ,  Jerry D. Smith ,  Michael Cunningham ,  John B. Robbins

发明人： Franklin L. Allen ,  Eugene C. Davis ,  Lawrence D. Dyer ,  Jerry B. Medders ,  Vikki S. Simpson ,  Jerry D. Smith ,  Michael Cunningham ,  John B. Robbins

IPC分类号： B24B9/06 ,  H01L21/304 ,  H01L21/306

CPC分类号： H01L21/02008 ,  B24B9/065 ,  Y10S438/959

摘要： The protection to the backside of the semiconductor wafer is accomplished by applying a layer of silicon oxide or silicon nitride or other deposited material to the back surface of a semiconductor wafer to protect against particles, scratches, and etching by mild caustic solutions. The layer remains in place during all three processes, edge pre-polish, mirror edge polish, and wafer polish.

摘要翻译： 通过将半导体晶片的背面施加一层氧化硅或氮化硅或其它沉积材料来保护半导体晶片的背面，以防止颗粒，划痕和用温和的苛性碱溶液蚀刻。 在所有三个过程中，该层保持原位，边缘预抛光，镜面抛光和晶圆抛光。

公开(公告)号：US5204098A

公开(公告)日：1993-04-20

申请号：US155799

申请日：1988-02-16

申请人： Shousun C. Szu ,  Rachel Schneerson ,  John B. Robbins

发明人： Shousun C. Szu ,  Rachel Schneerson ,  John B. Robbins

IPC分类号： A61K39/05 ,  A61K39/02 ,  A61K39/08 ,  A61K39/106 ,  A61K39/112 ,  A61K39/145 ,  A61K39/385 ,  A61K39/39 ,  A61K39/395 ,  A61K47/48 ,  C07K17/10

CPC分类号： A61K47/4833 ,  A61K39/0275 ,  A61K2039/6037 ,  Y10S424/831 ,  Y10S435/961 ,  Y10S530/807

摘要： Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.

摘要翻译： 与毒素依赖性蛋白质结合的Vi荚膜多糖可用于增强抗体应答并将T依赖性质转化为Vi荚膜多糖。 异双功能交联剂可用于将Vi荚膜多糖的硫醇衍生物与白喉，破伤风类毒素，霍乱毒素和流感嗜血杆菌等蛋白质结合。

公开(公告)号：US08747863B2

公开(公告)日：2014-06-10

申请号：US13059051

申请日：2009-08-14

申请人： John B. Robbins ,  Rachel Schneerson ,  Joanna Kubler-Kielb ,  Christopher P. Mocca ,  Evguenii Vinogradov

发明人： John B. Robbins ,  Rachel Schneerson ,  Joanna Kubler-Kielb ,  Christopher P. Mocca ,  Evguenii Vinogradov

IPC分类号： A61K49/00 ,  A61K39/00 ,  A61K47/00 ,  A61K39/02 ,  A61K39/385 ,  A61K47/06

CPC分类号： A61K39/02 ,  A61K39/0283 ,  A61K39/385 ,  A61K47/06 ,  A61K47/6415 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081 ,  Y02A50/476

摘要： Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an Shigella sonnei infection. The disclosed immunogenic conjugates have the general structure: Pr—Sr—O—N═C-Kdo-OS wherein Pr is a carrier protein, Sr is an optional spacer moiety, Kdo is an 3-deoxy-D-manno-octulosonic acid or a derivative thereof, and OS is an oligosaccharide or polysaccharide obtained from S. sonnei. In specific examples, the immunogenic conjugates include the core oligosaccharide obtained from S. sonnei having the structure: wherein R is between 1 and 10 disaccharide repeat units. In specific examples, the disaccharide repeat unit included in the immunogenic conjugate has the structure: α-L-AltNAcA-3-β-FucNAc4N-4-.

摘要翻译： 公开了包括这种免疫原性缀合物的免疫原性缀合物和治疗组合物。 还公开了治疗和/或抑制志贺氏杆菌感染的方法。 所公开的免疫原性缀合物具有以下通用结构：Pr-Sr-O-N = C-Kdo-OS，其中Pr是载体蛋白，Sr是任选的间隔子部分，Kdo是3-脱氧-D-丙氨酸辛酯酸或 其衍生物，OS是从S. sonnei获得的寡糖或多糖。 在具体实例中，免疫原性缀合物包括从具有以下结构的S. sonnei获得的核心寡糖：其中R为1至10个二糖重复单元。 在具体实例中，包含在免疫原性缀合物中的二糖重复单元具有以下结构：α-L-AltNAcA-3-＆bgr-FucNAc4N-4-。

公开(公告)号：US08658180B2

公开(公告)日：2014-02-25

申请号：US12541804

申请日：2009-08-14

申请人： Mark A. Miller ,  Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Zuzana Biesova ,  Jerry Keith

发明人： Mark A. Miller ,  Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Zuzana Biesova ,  Jerry Keith

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/12 ,  A61K39/385

CPC分类号： C07K17/06 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/34 ,  C12N2760/16122 ,  C12N2760/16134

摘要： Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.

摘要翻译： 公开了具有以下通式的免疫原性缀合物：M2e-Cys-S-CH2-C（O）-NH-CH2-CH2-C（O-NH-Lys-Pr），M2e是流感M2胞外域（M2e）肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基，Pr是载体蛋白。 还公开了分离的免疫原，其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段，其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域 。 还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。

公开(公告)号：US08481048B2

公开(公告)日：2013-07-09

申请号：US12582420

申请日：2009-10-20

申请人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  Fathy Majadly ,  Stephen H. Leppla ,  John B. Robbins ,  Darrell T. Liu ,  Joseph Shiloach

发明人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  Fathy Majadly ,  Stephen H. Leppla ,  John B. Robbins ,  Darrell T. Liu ,  Joseph Shiloach

IPC分类号： A61K39/385 ,  C07K17/00 ,  A61P37/04

CPC分类号： C07K14/32 ,  A61K39/385 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/627

摘要： Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazine-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.

摘要翻译： 制备免疫原性缀合物的方法，其包括与载体共价连接的半抗原或抗原。 所述方法包括使第一试剂与二酰肼反应，得到肼修饰的第一试剂，其中第一试剂是半抗原，抗原或载体; 使第二试剂与苯甲醛化合物反应，得到苯甲醛修饰的第二试剂，其中第二试剂是半抗原，抗原或载体，条件是第一试剂或第二试剂是载体; 并使肼修饰的第一试剂与苯甲醛修饰的第二试剂反应，得到包含通过腙键与载体共价连接的半抗原或抗原的免疫原性缀合物。

公开(公告)号：US08268696B2

公开(公告)日：2012-09-18

申请号：US12964430

申请日：2010-12-09

申请人： Scott R. Summerfelt ,  Stephen A. Meisner ,  John B. Robbins

发明人： Scott R. Summerfelt ,  Stephen A. Meisner ,  John B. Robbins

IPC分类号： H01L21/762

CPC分类号： H01L23/544 ,  H01L2223/54426 ,  H01L2223/54453 ,  H01L2223/5448 ,  H01L2924/0002 ,  H01L2924/00

摘要： An IC alignment mark in a contact metal layer for use under an opaque layer, and a process for forming the alignment mark, are disclosed. The alignment mark includes contact metal fields, each several microns wide, with an array of PMD pillars in the interior, formed during contact etch, contact metal deposition and selective contact metal removal processes. The pillars are arrayed such that all exposed surfaces of the contact metal are planar. One configuration is a rectangular array in which every other row is laterally offset by one-half of the column spacing. Horizontal dimensions of the pillars are selected to maximize the contact metal fill factor, while providing sufficient adhesion to the underlying substrate during processing. The contact metal is at least 15 nanometers lower than the PMD layer surrounding the alignment mark, as a result of the contact metal removal process.

公开(公告)号：US20110306176A1

公开(公告)日：2011-12-15

申请号：US12964430

申请日：2010-12-09

申请人： Scott R. Summerfelt ,  Stephen A. Meisner ,  John B. Robbins

发明人： Scott R. Summerfelt ,  Stephen A. Meisner ,  John B. Robbins

IPC分类号： H01L21/762

CPC分类号： H01L23/544 ,  H01L2223/54426 ,  H01L2223/54453 ,  H01L2223/5448 ,  H01L2924/0002 ,  H01L2924/00

摘要： An IC alignment mark in a contact metal layer for use under an opaque layer, and a process for forming the alignment mark, are disclosed. The alignment mark includes contact metal fields, each several microns wide, with an array of PMD pillars in the interior, formed during contact etch, contact metal deposition and selective contact metal removal processes. The pillars are arrayed such that all exposed surfaces of the contact metal are planar. One configuration is a rectangular array in which every other row is laterally offset by one-half of the column spacing. Horizontal dimensions of the pillars are selected to maximize the contact metal fill factor, while providing sufficient adhesion to the underlying substrate during processing. The contact metal is at least 15 nanometers lower than the PMD layer surrounding the alignment mark, as a result of the contact metal removal process.

摘要翻译： 公开了在不透明层下使用的接触金属层中的IC对准标记和用于形成对准标记的工艺。 对准标记包括几微米宽的接触金属场，在接触蚀刻，接触金属沉积和选择性接触金属去除过程期间形成在内部的PMD柱阵列。 柱子被排列成使得接触金属的所有暴露表面是平面的。 一个配置是矩形阵列，其中每隔一行被横向偏移列间距的一半。 选择柱的水平尺寸以使接触金属填充因子最大化，同时在处理期间向下面的基底提供足够的粘附。 作为接触金属去除过程的结果，接触金属比围绕对准标记的PMD层低至少15纳米。