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40 条记录 (耗时 0.038 秒)

    Temperature-responsive polymer/polymer complex
    32.
    发明授权
    Temperature-responsive polymer/polymer complex 有权
    温度敏感聚合物/聚合物复合物

    公开(公告)号：US06863437B2

    公开(公告)日：2005-03-08

    申请号：US10362167

    申请日：2001-08-20

    申请人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Kazunori Kataoka ,  Katsuhiko Ueno

    发明人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Kazunori Kataoka ,  Katsuhiko Ueno

    IPC分类号： C08L29/04 ,  C08L33/26 ,  C08L71/02 ,  C12N11/08 ,  G01N25/20 ,  G01K1/00 ,  G01K11/16

    CPC分类号： C12N11/08 ,  C08L29/04 ,  C08L33/26 ,  C08L71/02 ,  Y10S430/165 ,  C08L2666/14 ,  C08L2666/04 ,  C08L2666/02

    摘要： The problem of the invention is to find a polymer mixture which forms an inter-polymer complex by being responsive to temperature even under neutral to alkaline conditions. According to the invention, a temperature responsive inter-polymer complex capable of showing thermal responsiveness in an aqueous solution, which contains a poly-N-acetylacrylamide or polyvinyl alcohol and polyethylene glycol, polyacrylamide or polymethacylamide, is applied to separating agents, immobilized enzymes, denatured protein modifiers, separation method or concentration of microorganisms, purification or concentration of nucleic acids, drug-releasing microcapsules and the like.

    摘要翻译： 本发明的问题是找到一种通过即使在中性至碱性条件下也适应于温度形成聚合物间络合物的聚合物混合物。 根据本发明，能够在包含聚-N-乙酰丙烯酰胺或聚乙烯醇和聚乙二醇，聚丙烯酰胺或聚甲基酰胺的水溶液中显示热响应性的温度敏感性聚合物络合物被施加到分离剂，固定化酶， 变性蛋白质改性剂，分离方法或微生物浓度，核酸的纯化或浓缩，药物释放微胶囊等。

    Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same
    35.
    发明授权
    Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same 有权
    具有上临界溶解温度的聚合物的水溶液，用聚合物改性的颗粒的水分散体和储存聚合物的方法

    公开(公告)号：US07976728B2

    公开(公告)日：2011-07-12

    申请号：US12147269

    申请日：2008-06-26

    申请人： Masaru Eguchi ,  Noriyuki Ohnishi

    发明人： Masaru Eguchi ,  Noriyuki Ohnishi

    IPC分类号： C08F20/54 ,  C08F6/06

    CPC分类号： C09D133/26 ,  C08F220/58 ,  C08F220/60 ,  C08K3/24

    摘要： It is intended to provide an aqueous solution of a thermoresponsive polymer and an aqueous dispersion of a thermoresponsive particle, which show an upper critical solution temperature (UCST) and are capable of maintaining a dissolved state and a dispersed state, respectively, even if they are stored for a long period of time at a temperature at which a ligand such as an antibody or an antigen is not inactivated. A UCST lowering agent is incorporated in a predetermined amount in an aqueous solution of a thermoresponsive polymer which shows a UCST in a state of containing water or an aqueous dispersion of a thermoresponsive particle containing the polymer, thereby lowering the UCST of the aqueous solution or aqueous dispersion to less than the storage temperature, and the resulting aqueous solution or aqueous dispersion is stored.

    摘要翻译： 旨在提供热敏聚合物的水溶液和热反应性颗粒的水分散体，其显示出上限临界溶解温度（UCST），并且能够分别保持溶解状态和分散状态，即使它们是 在抗体或抗原等配体未失活的温度下长时间贮存。 将UCST降低剂以预定量加入到表现出包含水的UCST或包含聚合物的热敏颗粒的水分散体的热稳定聚合物的水溶液中，从而降低水溶液的UCST或水溶液 分散至低于储存温度，并将所得水溶液或水分散体储存。

    WATER-SOLUBLE CATIONIC MAGNETIC FINE PARTICLES AND METHOD FOR SEPARATING OR DETECTING LIPID VESICLE USING THE SAME
    37.
    发明申请
    WATER-SOLUBLE CATIONIC MAGNETIC FINE PARTICLES AND METHOD FOR SEPARATING OR DETECTING LIPID VESICLE USING THE SAME 审中-公开
    水溶性阳离子磁性颗粒和使用其分离或检测脂肪膜的方法

    公开(公告)号：US20070105094A1

    公开(公告)日：2007-05-10

    申请号：US11551365

    申请日：2006-10-20

    申请人： Masato Fujita ,  Noriyuki Ohnishi

    发明人： Masato Fujita ,  Noriyuki Ohnishi

    IPC分类号： C12Q1/70

    CPC分类号： G01N33/54326 ,  C12N2730/10111 ,  G01N33/56983

    摘要： A phospholipid vesicle such as a virus is to be rapidly separated (concentrated, roughly purified) and good detection (diagnosis) results can be obtained with suppressing inhibition of virus-denature, PCR inhibition, latex-aggregation inhibition, and the like. Moreover, the above operations are to be automated. A phospholipid vesicle is separated using a water-soluble cationic magnetic fine particle by a composite formation through a covalent bond or physical adsorption of a substance having a cationic functional group, a substance having a hydroxyl group, and a substance having magnetism.

    摘要翻译： 要快速分离（浓缩，大致纯化）磷脂囊泡，通过抑制病毒变性，PCR抑制，胶乳聚集抑制等，可以获得良好的检测（诊断）结果。 此外，上述操作将被自动化。 使用水溶性阳离子磁性细颗粒通过共价键或具有阳离子官能团的物质，具有羟基的物质和具有磁性的物质的共价键或物理吸附，使用水溶性阳离子磁性细颗粒分离磷脂囊泡。

    Polymer having an upper critical solution temperature
    38.
    发明授权
    Polymer having an upper critical solution temperature 有权
    具有上临界溶解温度的聚合物

    公开(公告)号：US07195925B2

    公开(公告)日：2007-03-27

    申请号：US10362173

    申请日：2001-08-20

    申请人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Kazunori Kataoka ,  Katsuhiko Ueno

    发明人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Kazunori Kataoka ,  Katsuhiko Ueno

    IPC分类号： G01N33/545 ,  C07K17/08 ,  C12N11/08 ,  C07D495/04 ,  C08F20/56 ,  A61K47/48

    CPC分类号： C12N11/08 ,  C08F220/58 ,  C08F220/60 ,  Y10S530/815

    摘要： The invention relates to a stimulus-responding polymer obtained by polymerizing at least a monomer represented by a general formula (1) and a monomer represented by a general formula (2), and a separation method or concentration method of microorganisms, a purification method, detection method or concentration method of nucleic acids, a separating agent, a separation method of biomaterials and a conversion method of materials, which use this polymer, (in the formula, R11 represents hydrogen atom or methyl group, and R12 represents single bond or a straight or branched alkylene group having from 1 to 5 carbon atoms) (in the formula, R13 represents hydrogen atom or methyl group, and R14 represents hydrogen atom, a straight, branched or cyclic alkyl group, alkoxyl group or alkylamino group having from 1 to 10 carbon atoms, an aryl group or a heterocyclic group).

    摘要翻译： 本发明涉及通过聚合至少一种由通式（1）表示的单体和由通式（2）表示的单体获得的刺激响应聚合物，以及微生物的分离方法或浓缩方法，纯化方法， 核酸的检测方法或浓缩方法，分离剂，生物材料的分离方法和使用该聚合物的材料的转化方法，

    Polymerizable biotin derivatives, biotin polymer, and polymer responsive to avidin stimulation
    39.
    发明授权
    Polymerizable biotin derivatives, biotin polymer, and polymer responsive to avidin stimulation 有权
    可聚合的生物素衍生物，生物素聚合物和对抗生物素蛋白刺激有反应的聚合物

    公开(公告)号：US07052917B1

    公开(公告)日：2006-05-30

    申请号：US10048230

    申请日：2000-07-28

    申请人： Noriyuki Ohnishi ,  Mikiko Yoshida ,  Kazunori Kataoka ,  Katsuhiko Ueno

    发明人： Noriyuki Ohnishi ,  Mikiko Yoshida ,  Kazunori Kataoka ,  Katsuhiko Ueno

    IPC分类号： G01N33/545 ,  C07K17/08

    CPC分类号： C07D495/04 ,  C08F20/38 ,  C08F246/00

    摘要： The present invention is to prepare a novel polymerizable biotin derivative represented by formula (I) shown below and make it possible to synthesize or design a polyfunctional or multifunctional polymer using the derivative. In formula (I), R2 represents a hydrogen atom or an alkyl group, R3 and R4 each independently represents a hydrogen atom, an alkyl group or an aryl group, T represents an oxygen atom or ═NH, W represents a single bond, a carbonyl group, a thiocarbonyl group or a C1-5 alkylene group, U represents a single bond or —NH—, X represents a single bond, a C1-8 hydrocarbon bond, an oxygen atom or —NH—, Y represents a single bond, a carbonyl group, a thiocarbonyl group, —NH—, a 1,2-dioxyethylene group or a 1,2-diaminoethylene group, Z represents a single bond, a carbonyl group, a thiocarbonyl group, a C1-5 alkylene group, an oxygen atom or —NH—, and V represents a single bond or a C1-5 alkylene group.

    摘要翻译： 本发明是为了制备由下述式（I）表示的新型可聚合生物素衍生物，并且可以使用该衍生物合成或设计多官能或多官能聚合物。 在式（I）中，R 2表示氢原子或烷基，R 3和R 4各自独立地表示氢原子， 烷基或芳基，T表示氧原子或-NH，W表示单键，羰基，硫代羰基或C 1-5亚烷基，U表示单 键或-NH-，X表示单键，C 1-8烃键，氧原子或-NH-，Y表示单键，羰基，硫代羰基， NH-，1,2-二氧乙烯基或1,2-二氨基亚乙基，Z表示单键，羰基，硫代羰基，C 1-5 - 亚烷基，氧 原子或-NH-，V表示单键或C 1-5 - 亚烷基。

    Process for producing alkenyl ethers
    40.
    发明授权
    Process for producing alkenyl ethers 失效
    烯基醚的制备方法

    公开(公告)号：US5053556A

    公开(公告)日：1991-10-01

    申请号：US466582

    申请日：1990-01-17

    申请人： Noriyuki Ohnishi

    发明人： Noriyuki Ohnishi

    IPC分类号： C07C41/01 ,  C07C41/28 ,  C07C43/15 ,  C07C43/188

    CPC分类号： C07C41/28 ,  C07C41/01

    摘要： A one-step process for producing an alkenyl ether in only one step and under mild conditions by reacting an aldehyde of the formula ##STR1## with an alcohol of the formulaR.sup.3 --OHin the presence of an acidic catalyst in liquid phase, and recovering as the reaction product an alkenyl ether of the formula ##STR2## wherein R.sup.1 is a 2-8 C alkyl or R--CH.sub.2 --CH.dbd. wherein R is a 1-8 C alkyl group,R.sup.2 is a 1-6 C alkyl,R.sup.3 is a linear or branched 6-12 C alkyl, a cyclohexyl, a hydroxyhexamethylenyl or ##STR3## wherein R' is H and n is 2 or 3, R.sup.4 is hydrogen or R--CH.sub.2 --CH.dbd. wherein R is a 1-8 C alkyl group, andR.sup.5 is a 2-8 C alkyl or R--CH.dbd.CH-- wherein R is a 1-8 C alkyl.

    摘要翻译： 在一个步骤中，在温和条件下，通过在液相酸性催化剂存在下使式（ⅩⅩⅧ）的醛与式R 3 -OH的醇反应，然后回收 作为反应产物，具有式“IMAGE”的烯基醚，其中R 1是2-8 C烷基或R-CH 2 -CH =其中R是1-8 C烷基，R 2是1-6 C烷基，R 3 是直链或支链6-12烷基，环己基，羟基六亚甲基或其中R'是H，n是2或3，R4是氢或R-CH2-CH =，其中R是1-8C 烷基，R5是2-8C烷基或R-CH = CH-，其中R是1-8C烷基。