Use of isoindolinone derivatives as stabilizers for organic materials
    33.
    发明授权
    Use of isoindolinone derivatives as stabilizers for organic materials 失效
    异吲哚啉酮衍生物作为有机材料的稳定剂的使用

    公开(公告)号:US06210657B1

    公开(公告)日:2001-04-03

    申请号:US09207624

    申请日:1998-12-09

    IPC分类号: A61K742

    摘要: Isoindolinone derivatives of the formula I, in which the variables have the following meanings: R1 is hydrogen, COOR4, COR4, CONR4R5, CN, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl or heteroaryl, substituted or unsubstituted; R1 and R2 together are C7-C10-bicycloalkyl or C7-C10-bicycloalkenyl; R3 is hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl or heteroaryl, substituted or unsubstituted, substituents which confer solubility in water, selected from the group consisting of carboxylate, sulfonate or ammonium radicals; R4 and R5 independently of one another are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl; aryl or heteroaryl, substituted or unsubstituted; are used as stabilizers for organic materials.

    摘要翻译: 式I的异吲哚啉酮衍生物,其中变量具有以下含义:R1是氢,COOR4,COR4,CONR4R5,CN,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3-C10- 环烯基,芳基或杂芳基,取代或未取代的; R1和R2一起是C7-C10-双环烷基或C7-C10-双环烯基; R3是氢,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3 -C 10 - 环烯基,C 1 -C 12 - 烷氧基,C 1 -C 20 - 烷氧基羰基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,芳基或杂芳基,取代或未取代的赋予水溶性的取代基, 羧酸酯,磺酸酯或铵基; R 4和R 5彼此独立地是氢,C 1 -C 20 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基; 芳基或杂芳基,取代或未取代的;被用作有机材料的稳定剂。

    Aqueous copolymer dispersions of water-soluble monomers with N-vinyl
groups and hydrophobic monomers
    35.
    发明授权
    Aqueous copolymer dispersions of water-soluble monomers with N-vinyl groups and hydrophobic monomers 失效
    水溶性单体与N-乙烯基和疏水性单体的水共聚物分散体

    公开(公告)号:US6107397A

    公开(公告)日:2000-08-22

    申请号:US42744

    申请日:1998-03-17

    CPC分类号: A61K9/5026 C08F226/00

    摘要: An aqueous copolymer dispersion is prepared by free-radical emulsion co-polymerization of a monomer mixture ofi) from 10 to 70% by weight of at least one nonionic monomer A having a water-solubility of more than 60 g/l at 25.degree. C., and being selected from the group consisting of N-vinyllactams having from 6 to 8 carbon atoms, N-vinylformamide and N-methyl-N-vinylacetamide,ii) from 30 to 90% by weight of at least one monoethylenically unsaturated hydrophobic monomer B having a water-solubility of less than 60 g/l at 25.degree. C.,and optionally further comprisingiii) up to 5% by weight of at least one monoethylenically unsaturated monomer C which has at least one ionic and/or ionizable functional group,iv) up to 10% by weight of at least one monomer D which has at least 2 ethylenically unsaturated bonds,v) up to 20% by weight of at least one further monoethylenically unsaturated monomer E, which is different from the monomers A and C, and has a water-solubility of >60 g/l at 25.degree. C.,in the presence of a water-soluble polymerization initiator in water or an aqueous solvent.

    摘要翻译: 通过自由基乳液共聚制备水性共聚物分散体,该单体混合物为i)10至70重量%的至少一种在25℃下具有大于60g / l的水溶性的非离子单体A 并且选自具有6至8个碳原子的N-乙烯基内酰胺,N-乙烯基甲酰胺和N-甲基-N-乙烯基乙酰胺,ii)30至90重量%的至少一种单烯属不饱和疏水性 单体B在25℃具有小于60g / l的水溶性,并且任选地还包含iii)至多5重量%的至少一种具有至少一个离子和/或可离子化的单烯属不饱和单体C 官能团,iv)至多10重量%的至少一种具有至少2个烯键式不饱和键的单体D,v)至多20重量%的至少一种另外的单烯属不饱和单体E,其不同于单体 A和C,并且在25℃下的水溶解度> 60g / l 在水或水溶剂中存在水溶性聚合引发剂的情况下。

    Cosmetic and pharmaceutical preparations comprising photostable UV
filters
    36.
    发明授权
    Cosmetic and pharmaceutical preparations comprising photostable UV filters 失效
    包含光稳定型紫外线过滤器的化妆品和药物制剂

    公开(公告)号:US6090374A

    公开(公告)日:2000-07-18

    申请号:US172672

    申请日:1998-10-15

    摘要: The use of substituted .alpha.-methylstyrene derivatives of the formula I, ##STR1## where the variables have the following meanings: R.sup.1 C.sub.4 -C.sub.10 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water and which are selected from the group consisting of carboxylate, sulfonate or ammonium residues;R.sup.2 hydrogen, C.sub.2 -C.sub.10 -alkyl, C.sub.1 -C.sub.12 -alkoxy;R.sup.3 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN;R.sup.4 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN; where the substituents R.sup.3 and R.sup.4 are identical in each case;R.sup.5 andR.sup.6 independently of one another hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, hetaryl, unsubstituted or substituted;as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with UV-absorbing compounds known per se for cosmetic and pharmaceutical preparations.

    摘要翻译: 使用式I的取代的α-甲基苯乙烯衍生物,其中变量具有以下含义:R 1 C 4 -C 10 - 烷氧基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,赋予在水中溶解度并且被选择的取代基 由羧酸盐,磺酸盐或铵残基组成的组; R2氢,C2-C10-烷基,C1-C12-烷氧基; R3 COOR5,COR5,CONR5R6,CN; R4 COOR5,COR5,CONR5R6,CN; 其中取代基R 3和R 4在每种情况下相同; R 5和R 6彼此独立地为氢,C 1 -C 12 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基,芳基,杂芳基,未取代或取代的; 作为化妆品和药物制剂中的光稳定紫外线过滤器,用于保护人体皮肤或人体毛发免受太阳光线的照射,或者与本身已知的用于化妆品和药物制剂的紫外线吸收化合物一起使用。

    Cosmetic and pharmaceutical preparations containing photostable UV filters
    39.
    发明授权
    Cosmetic and pharmaceutical preparations containing photostable UV filters 有权
    含有光稳定紫外线过滤器的化妆品和药物制剂

    公开(公告)号:US06545174B2

    公开(公告)日:2003-04-08

    申请号:US09765624

    申请日:2001-01-22

    IPC分类号: C07C6976

    摘要: 4,4-Diarylbutadienes of the formula I, where the diene system has the Z,Z; Z,E; E,Z or E,E configuration or a mixture thereof, and where the variables independently of one another have the following meanings: R1 and R2 are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl, hetaryl, unsubstituted or substituted, substituents which confer solubility in water and are selected from the group consisting of carboxylate, sulfonate, or ammonium residues; R3 is COOR5, CONR5R6; R4 is COOR6, CONR5R6; R5 and R6 are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C7-C10-bicycloalkyl, C3-C10-cycloalkenyl, C7-C10-bicycloalkenyl, aryl, hetaryl, unsubstituted or substituted; n is 1 to 3; and R3 and R4 are not COOCH3 when R1 and R2 are hydrogen, are used as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.

    摘要翻译: 式I的4,4-二芳基丁二烯,其中二烯体系具有Z,Z; Z,E; E,Z或E,E构型或其混合物,其中彼此独立的变量具有以下含义:R 1和R 2为氢,C 1 -C 20 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基, C 3 -C 10 - 环烯基,C 1 -C 12 - 烷氧基,C 1 -C 20烷氧基羰基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,芳基,杂芳基,未取代或取代的取代基,其赋予在水中的溶解性并且选自 由羧酸盐,磺酸盐或铵残基组成; R3为COOR5,CONR5R6; R4是COOR6,CONR5R6; R 5和R 6是氢,C 1 -C 20烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 7 -C 10 - 双环烷基,C 3 -C 10 - 环烯基,C 7 -C 10 - 双环烯基,芳基,杂芳基,未取代或取代的; n为1〜3; 当R 1和R 2为氢时,R 3和R 4不是COOCH 3,用作化妆品和药物制剂中的光稳定性UV过滤剂,以保护人皮肤或人类头发免受太阳光线的影响,单独或与在UV区域吸收的化合物一起, 本身就是化妆品和药物制剂。