公开(公告)号：US20130120002A1

公开(公告)日：2013-05-16

申请号：US13734011

申请日：2013-01-04

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Shinji Omori ,  Ikuya Oshige

IPC: G01R31/36

CPC classification number: G01R31/36 ,  G01N27/221

Abstract: A transmission line substrate includes at least an insulating layer of a predetermined thickness, a pair of conductor layers arranged in a state of being opposed to each other such that the insulating layer is interposed between the conductor layers, the pair of conductor layers functioning as a high-frequency transmission line, and a fault part formed so as to make the conductor layer on one side disconnected, into which a sample to be measured can be introduced.

Abstract translation: 传输线基板至少包括预定厚度的绝缘层，一对导体层以彼此相对的状态布置，使得绝缘层插入在导体层之间，一对导体层用作 高频传输线和形成为使导线层一侧断开的故障部分，可以引入要测量的样品。

公开(公告)号：US11802825B2

公开(公告)日：2023-10-31

申请号：US16337598

申请日：2017-07-21

Applicant: Sony Corporation

Inventor： Aya Murata ,  Yoshihito Hayashi ,  Kenzo Machida ,  Seungmin Lee

IPC: G01N11/00 ,  G01N19/00 ,  G01N27/22 ,  G01N33/49 ,  G01N33/86

CPC classification number: G01N11/00 ,  G01N19/00 ,  G01N27/22 ,  G01N33/49 ,  G01N33/86 ,  G01N2011/0066

Abstract: A measurement method of simply and quickly measuring platelet aggregation, is provided.
The measurement method is a platelet aggregation analysis method, including:



a step of adding a platelet-inducing substance and a calcium salt to a platelet-containing specimen;
a step of stirring the platelet-containing specimen; and a step of acquiring measurement data of an electrical characteristic and/or viscoelasticity of the platelet-containing specimen.

公开(公告)号：US11067523B2

公开(公告)日：2021-07-20

申请号：US15289636

申请日：2016-10-10

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi

IPC: G01N27/02 ,  G01N33/49 ,  G01N33/86

Abstract: A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed. The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed.

公开(公告)号：US10948478B2

公开(公告)日：2021-03-16

申请号：US14777906

申请日：2014-02-18

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N27/02 ,  G01N33/487

Abstract: A blood state analysis device, blood state analysis system, blood state analysis method, and program that enable analysis of the state of blood easily and precisely is provided. The blood state analysis device includes: an extraction unit configured to extract at least one feature from chronological change data of an electrical characteristic of blood in two or more frequency bands; an evaluation unit configured to evaluate a state of the blood on the basis of the at least one feature extracted by the extraction unit; and a classification unit configured to classify the blood on the basis of a result of evaluation conducted by the evaluation unit.

公开(公告)号：US10794896B2

公开(公告)日：2020-10-06

申请号：US16071663

申请日：2016-11-16

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Shinji Omori

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/22

Abstract: Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample.The blood coagulation system examination module includes a thrombin potential examination unit configured to examine thrombin potential on the basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.

公开(公告)号：US10281452B2

公开(公告)日：2019-05-07

申请号：US14391090

申请日：2013-03-05

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marc-Aurele Brun ,  Isao Uchimura

IPC: G01N27/02 ,  G01N27/06 ,  G01N33/49 ,  G01N33/487

Abstract: There is provided a blood coagulation system analyzer, including a measurement section and an analysis section. The measurement section measures a time change of impedance of a blood sample, which is obtainable by applying an alternating electric field to the blood sample. The analysis section extracts a parameter indicating the characteristics of the impedance from the measured data of the time change of the impedance. Furthermore, the analysis section analyzes a degree of enhancement of blood coagulation on the basis of a comparison of the extracted parameter with at least one reference value which defines the criteria of the enhancement of blood coagulation.

公开(公告)号：US10234469B2

公开(公告)日：2019-03-19

申请号：US15302914

申请日：2015-04-09

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49

Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

公开(公告)号：US20170023597A1

公开(公告)日：2017-01-26

申请号：US15302562

申请日：2015-02-19

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/02

Abstract: To provide a technology that allows for simple and highly accurate evaluation of the condition of blood.Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.

Abstract translation: 本发明提供一种血液分析装置，用于分析添加了选自抗凝治疗消除剂，凝血激活剂，抗凝剂，血小板活化剂和抗血小板剂中的至少一种药物的血液样品的状态，该装置 包括用于基于血液样品的血细胞比容和/或血红蛋白含量控制待添加到血液样品中的药物的剂量的药物剂量控制单元。

公开(公告)号：US20160299124A1

公开(公告)日：2016-10-13

申请号：US14777906

申请日：2014-02-18

Applicant: SONY CORPORATION

Inventor： Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N33/487 ,  G01N27/02

Abstract: A blood state analysis device, blood state analysis system, blood state analysis method, and program that enable analysis of the state of blood easily and precisely is provided. The blood state analysis device includes: an extraction unit configured to extract at least one feature from chronological change data of an electrical characteristic of blood in two or more frequency bands; an evaluation unit configured to evaluate a state of the blood on the basis of the at least one feature extracted by the extraction unit; and a classification unit configured to classify the blood on the basis of a result of evaluation conducted by the evaluation unit.

Abstract translation: 提供了能够容易且精确地分析血液状态的血液状态分析装置，血液状态分析系统，血液状态分析方法和程序。 血液分析装置包括：提取单元，被配置为从两个或更多个频带中的血液的电特性的时间变化数据提取至少一个特征; 评估单元，被配置为基于由所述提取单元提取的所述至少一个特征来评估血液的状态; 以及分类单元，其被配置为基于由评估单元执行的评估结果对血液进行分类。

公开(公告)号：US20150346125A1

公开(公告)日：2015-12-03

申请号：US14760238

申请日：2013-12-03

Applicant: SONY CORPORATION

Inventor： Yoshihito Hayashi ,  Yoichi Katsumoto ,  Marcaurele Brun ,  Teppei Toyoizumi

IPC: G01N27/02 ,  G01N33/49

CPC classification number: G01N27/028 ,  G01N27/026 ,  G01N33/4905

Abstract: There is provided an electrical characteristic measuring device including a rotating mechanism that rotates a sample container to be filled with blood to be measured, to any angle, and a measurement unit that applies a voltage between a pair of electrodes installed in the sample container, and chronologically measures electrical characteristics of the blood.

Abstract translation: 提供了一种电特性测量装置，其包括旋转机构，该旋转机构使待测量的血液的样品容器旋转任何角度，以及在安装在样品容器中的一对电极之间施加电压的测量单元，以及 按时间顺序测量血液的电气特性。